EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics,

Süreyya Ekem; Nida Taşçılar; Esra Acıman Demirel; Banu Özen Barut; Handan Ankaralı; H. Atasoy

doi:10.21673/anadoluklin.180733

TR EN

Tipik ve Atipik Antipsikotik İlaç Kullanımına Bağlı EEG Anormallikleri

Öz

Amaç: Tipik antipsikotikler ve klozapin EEG anormalliklerine ve epileptik nöbetlere neden olabilir. Yeni kuşak antipsikotiklerin EEG üzerindeki etkileri çok fazla bilinmemektedir. Yapılan bu çalış- mada klozapin, ketiapin, risperidon ve olanzapin gibi atipik antipsikotikler, amisülpirid, aripiprazol, paliperidon gibi yeni diğer atipik antipsikotikler ve klorpromazin, haloperidol, zuklopentiksol, pimozid gibi tipik antipsikotiklerin EEG anormallikleri üzerine etkileri araştırılmıştır.

Gereç ve Yöntemler: Şizofreni veya şizoaffektif bozukluk tanılı 102 hasta prospektif olarak de- ğerlendirilerek EEG’leri çekildi. Bunların 82’si atipik [klozapin (n:16), risperidon (n:20), ketiapin (n:10), olanzapin (n:14), diğer yeni atipik antipsikotikler (n:10)] ve tipik [haloperidol (n:5), klorpromazin (n:2), zuklopentiksol (n:3), pimozid (n:2)] antipsikotik kullanıyordu, 20’si ise ilaç kullanmıyordu. Bu üç alt grup; cinsiyet ve yaş uyumlu sağlıklı kontrol grubunun (n=29) EEG’leri ile karşılaştırıldı.

Bulgular: Gruplar arasında demografik özellikler bakımından istatiksel olarak anlamlı fark saptanmadı. Hem ilaç kullanmayan hastaların hem de sağlıklı kontrollerin EEG’leri normaldi. Klozapin kullanan hastaların % 31,3’ünde (p < 0,05), ketiapin kullananların da %10’unda (p > 0,05) epileptik aktivite gözlendi. Epileptik aktivite dışındaki EEG anormallikleri tipik antipsikotik kullananların %58,3’ünde (p < 0,01), risperidon kullananlarında %35’inde (p < 0,01) saptandı. EEG ketiapin ve yeni atipik antipsikotik kullananların %80’inde normalken, tipik antipsikotik kullananların %33,3’ünde normaldi (p=0,012).

Tartışma ve Sonuç: Burada klozapinin en epileptojen antipsikotik olduğunu ve tipik antipsikotiklerin EEG’yi en fazla bozduğunu bulduk. Ancak klozapin tedavisi alan psikotik hastalarda EEG bir gerekliliktir. Epilepsinin eklendiği psikotik hastalara yeni atipik antipsikotikler verilebilir, çünkü EEG üzerine en az istenmeyen etkiler bu ilaçlarla gözlenmiştir. Buna ilaveten antipsikotik ilaçlar ve epilepsi eşiği arasındaki kompleks ilişkileri açığa çıkarmak için daha fazla bilimsel araştırmaya ihtiyaç olduğunu da vurgulanmamız lazımdır.

Anahtar Kelimeler

elektroensefalografi, tipik antipsikotikler, atipik antipsikotikler, epileptik aktivite

EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics,

Öz

Aim: Typical antipsychotics and clozapine could cause EEG abnormalities and risk of epileptic seizures. Little is known about the effects of newer antipsychotics on EEG. The present study therefore examined the risk of EEG abnormalities associated with the use of atypical antipsychotics [clozapine, quetiapine, risperidone, olanzapine and new atypical antipsychotics (amisulpride, aripiprazole, paliperidone)] and of the typical antipsychotics (chlorpromazine, haloperidol, zuclopenthixol, pimozide).

Materials and Methods: EEG patterns were prospectively investigated in 102 patients with schizophrenia or schizoaffective disorders. While 82 out of the 102 patients were under atypical [clozapine (n=16), risperidone (n=20), quetiapine (n=10), olanzapine (n=14), and new atypical antipsychotics (n=10)] and typical [haloperidol (n=5), chlorpromazine (n=2), zuclopenthixol (n=3), pimozide (n=2)] antipsychotic treatment, 20 of them were not under any treatment. These three groups were compared with a sex- and aged- matched control group of healthy volunteers(n=29).

Results: No statistically significant difference regarding demographic characteristics was found between the groups. Both the patients who were not on any medication and the healthy volunteers had normal EEG’s. Epileptic activity was observed in 31.3% of the patients under clozapine treatment (p<0.05) and in 10% of the patients under quetiapine treatment (p>0.05). EEG abnormalities other than epileptic activity were observed in 58.3% of the patients under typical antipsychotics (p<0.01) and 35% of the patients under risperidone treatment (p<0.01). EEG was normal in 78–80% of the patients using quetiapine and new atypical antipsychotics, compared to 33.3% of the patients under typical antipsychotic treatment (p=0.012).

Discussion and Conclusion: Herein, we found that clozapine was the most epileptogenic antipsychotic and that typical antipsychoticswere making the worse EEG changes. Nevertheless, in the psychotic patients under clozapine treatment EEG is a must. Psychotic patients with consequential epilepsy could be given new atypical antipsychotics because it has the least unwanted effects on EEG. Moreover, it should also be emphasized that there is a need for further scientific research to clarify all aspects characterizing the complex link between seizure threshold and psychotropic drugs.

Anahtar Kelimeler

electroencephalography,typical antipsychotics,atypical antipsychotics,epileptic activity

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Süreyya Ekem Bu kişi benim
Türkiye

Nida Taşçılar Bu kişi benim
Türkiye

Esra Acıman Demirel
Türkiye

Banu Özen Barut Bu kişi benim
Türkiye

Handan Ankaralı
Türkiye

H. Atasoy Bu kişi benim
Türkiye

Yayımlanma Tarihi

30 Nisan 2016

Gönderilme Tarihi

30 Mart 2016

Kabul Tarihi

6 Nisan 2016

Yayımlandığı Sayı

Yıl 2016 Cilt: 21 Sayı: 2

DOI

https://doi.org/10.21673/anadoluklin.180733

IZ

https://izlik.org/JA27NG47YN

APA

Ekem, S., Taşçılar, N., Acıman Demirel, E., Özen Barut, B., Ankaralı, H., & Atasoy, H. (2016). EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics,. Anatolian Clinic the Journal of Medical Sciences, 21(2), 97-104. https://doi.org/10.21673/anadoluklin.180733

AMA

1.Ekem S, Taşçılar N, Acıman Demirel E, Özen Barut B, Ankaralı H, Atasoy H. EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics,. Anadolu Klin. 2016;21(2):97-104. doi:10.21673/anadoluklin.180733

Chicago

Ekem, Süreyya, Nida Taşçılar, Esra Acıman Demirel, Banu Özen Barut, Handan Ankaralı, ve H. Atasoy. 2016. “EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics”,. Anatolian Clinic the Journal of Medical Sciences 21 (2): 97-104. https://doi.org/10.21673/anadoluklin.180733.

EndNote

Ekem S, Taşçılar N, Acıman Demirel E, Özen Barut B, Ankaralı H, Atasoy H (01 Nisan 2016) EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics,. Anatolian Clinic the Journal of Medical Sciences 21 2 97–104.

IEEE

[1]S. Ekem, N. Taşçılar, E. Acıman Demirel, B. Özen Barut, H. Ankaralı, ve H. Atasoy, “EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics”, Anadolu Klin, c. 21, sy 2, ss. 97–104, Nis. 2016, doi: 10.21673/anadoluklin.180733.

ISNAD

Ekem, Süreyya - Taşçılar, Nida - Acıman Demirel, Esra - Özen Barut, Banu - Ankaralı, Handan - Atasoy, H. “EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics”,. Anatolian Clinic the Journal of Medical Sciences 21/2 (01 Nisan 2016): 97-104. https://doi.org/10.21673/anadoluklin.180733.

JAMA

1.Ekem S, Taşçılar N, Acıman Demirel E, Özen Barut B, Ankaralı H, Atasoy H. EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics,. Anadolu Klin. 2016;21:97–104.

MLA

Ekem, Süreyya, vd. “EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics”,. Anatolian Clinic the Journal of Medical Sciences, c. 21, sy 2, Nisan 2016, ss. 97-104, doi:10.21673/anadoluklin.180733.

Vancouver

1.Süreyya Ekem, Nida Taşçılar, Esra Acıman Demirel, Banu Özen Barut, Handan Ankaralı, H. Atasoy. EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics,. Anadolu Klin. 01 Nisan 2016;21(2):97-104. doi:10.21673/anadoluklin.180733

13151 This Journal licensed under a CC BY-NC (Creative Commons Attribution-NonCommercial 4.0) International License.

Tipik ve Atipik Antipsikotik İlaç Kullanımına Bağlı EEG Anormallikleri

Öz

Anahtar Kelimeler

EEG Abnormalities Associated with the Use of Typical and Atypical Antipsychotics,

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster