Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy?
Öz
Aim: The aim of the present study is to investigate the effect of corticosteroid-containing nasal spray on development of central serous chorioretinopathy (CSC) development and thickness of choroid and Retinal pigment epithelium-Bruch membrane complex (RPE-BM).
Materials and Methods: Twenty-nine patients (18 female, 11 male) receiving nasal mometasone spray were included in the study. Systolic blood pressure (SBP), diastolic blood pressure (DBP), visual acuity, intraocular pressure and choroidal and RPE-BM thicknesses were measured before and one week and one month after drug administration. Optical coherence tomography sections were examined in terms of CSCdevelopment. Measurements were made from the right eye.
Results: Central serous chorioretinopathy was not detected in any of the patients. Mean choroidal thickness measurements did not show any statistically significant changes between baseline values and follow-up measurements: On the temporal side 292.48±73.02 μm before the treatment, 296.83±79.09 μm at the first week, 295.41±74.13 μm at the first month (p = 0.405); at the subfovea 360.62±92.44 μm at baseline, 364.04±93.65 μm at the first week, and 365.66±95.86 μm at the first month (p = 0.208) under the fovea; on the nasal side, 282.86±96.11 μm at the beginning, 285.28±93.25 μm at the first week and 284.28±98.14 μm at the first month (p = 0.819). RPE-BM was measured as 21.65±2.86 μm at the beginning, 21.24±2.61 μm at the first week and 21.58±2.09 μm at the first month. Differences were not statistically significant (p = 0.450). There was no significant difference in intraocular pressure (p = 0.450), SBP (p = 0.257) and DBP (p = 0.249) measurements.
Discussion and Conclusion: Further studies are needed to determine the incidence of corticosteroid-induced SSR and cause-effect relationship between CSC development and choroid or RPE-BM thickness.
Anahtar Kelimeler
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