Metabolik Sendrom Tedavisinde Bağırsak Mikrobiyotasının Probiyotikler ve Özelinde Saccharomyces Boulardii ile Modülasyonu

Yıl 2017, Cilt: 22 Sayı: 2, 131 - 140, 07.03.2017

İhsan Boyacı , Süleyman Yıldırım

https://doi.org/10.21673/anadoluklin.260702

Öz

Metabolik sendrom insan metabolizmasındaki dengenin bozulmasını ifade eden glukoz intoleransı veya diyabetes mellitus, abdominal obezite, dislipidemi, hipertansiyon, kardiyovasküler anormalliklerin bir arada görüldüğü hastalıklar kümesidir. Barındırdığı riskli hastalıklardan dolayı da mortalite ve morbiditesi artmaktadır. Türkiye’de ve dünyada metabolik sendrom prevelansı epidemik seviyelere ulaşmak üzere ve ülkelerin ekonomisine ağır yükler getirmektedir. Metabolik sendrom tedavisinde başlıca hedef kalp hastalıkları riskini azaltmak ve hastalığı kontrol altında tutmaktır bunun içinde ilaç tedavisi ve son yıllarda obezite özelinde cerrahi tedaviler uygulanmaktadır. Ancak ilaç tedavileri hasta yaşamında ciddi ve kalıcı değişimler yapmadıkça bu hastalık grubuna kesin çözüm getirmekten çok uzaktır. Cerrahi tedaviler için ise kesin yargılarda bulunmak henüz çok erkendir. Son zamanlarda insan mikrobiyatası üzerine yapılan bilimsel çalışmalar bağırsak mikrobiyatasında ki homeostatik dengenin bozulması nedeniyle subklinik ve kronik bir inflamasyonun oluştuğu ve bununda glukoz metabolizmasının bozulmasında rolü olduğu gösterilmiştir. Bu nedenle bağırsak mikrobiyotasını probiyotikler kullanarak modüle edip metabolik sendrom hastalarının tedavisinde kullanmak etkili ve ekonomik bir çözüm fırsatı olabilir. Yeni çıkan bir çalışmada Everard ve arkadaşları (98), Tip 2 diyabetes mellitusu olan farelere verilen Saccharomyces boulardii diyabetin klinik belirteçlerini geriletmiş ve metabolik sendromlu hastaların tedavisinde kullanılabileceğinin ön verilerini göstermiştir.

 

 

 

 

 

 

 

Anahtar Kelimeler

Metabolik sendrom, sendrom x, insülin direnci, bağırsak mikrobiyota, probiotikler, saccharomyces boulardii

The modulation of gut microbiota with probiotics and especially with saccharomyces boulardii in treatment of metabolic syndrome

Öz

Metabolic Syndrome shows up with the group of diseases that mean the impairment of human metabolism such as, glucose intolerance or diabetes mellitus, abdominal obesity, dislipidemi , hypertension, cardiovascular. Because of risky diseases that Metabolic syndrome consists, morality and mordibity increase. In Turkey and also in the world the prevalence of metabolic syndrome almost reaches the epidemic level and it brings heavy burden to countries’ economies. The main goal of metabolic syndrome treatment is to minimize risks of heart diseases and to control the disease. To reach that goal medication and surgical treatment that are specified in obesity, have been applied. However it is too difficult to make an absolute solution unless the medication makes some serious and permanent changes in patient’s life. It is also too early to say that surgical treatment have absolute results. The last researches on human microbiota have shown that because of the impairment of the homeostatic balance in intestinal microbiota, subclinical and chronic inflammation occurs, and they also have shown that the inflammation has a role in the impairment of glucose metabolism. Therefore, to modulate the probiotics in the intestinal microbiota and use them for the treatment of metabolic syndrome can be an opportunity of an economic and an effective solution. In a new study, Everard and Everard’s friends(98) decrease the clinical indicators of Sacchromyces boulardii diabetes that has been given to mice that have Type2 diabetes mellitus and with that study, the preliminary data of using S. boulardii diabetes in the treatment of metabolic syndrome has been shown.

Anahtar Kelimeler

Metabolic syndrome, sendrom x, ınsulin resistance, intestinal microbiota, probiotics, saccharomyces boulardii

Kaynakça

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