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Hayatı Tehdit Eden Hiperkalsemi ile Başvuran Hipoparatiroidi Olgusu

Yıl 2017, Cilt: 22 Sayı: 3, 200 - 203, 25.09.2017
https://doi.org/10.21673/anadoluklin.320722

Öz

Süt-alkali sendromu ilk olarak peptik ülser hastalığı nedeniyle kalsiyum içeren antiasitleri yüksek
dozda kullanan hastalarda tanımlanmıştır. Hiperkalsemi, metabolik alkaloz ve akut böbrek
yetmezliği üçlemesinden oluşmaktadır. Sendromun modern ülser tedavilerinin geliştirilişiyle
azalan görülme sıklığı, günümüzde osteoporoz ve renal osteodistrofi nedeniyle kalsiyum kullanımına
bağlı olarak yeniden artmaya başlamıştır. Bu sunumda idiyopatik hipoparatiroidizm
nedeniyle kalsiyum karbonat ve aktif D vitamini tedavisi altında iken kliniğimize hayatı tehdit
eden hiperkalsemi, metabolik alkaloz ve akut böbrek yetmezliği tablosu ile başvuran bir hastayı
anlatmaktayız

Kaynakça

  • 1. Beall DP, Hensiee HB, Webb HR et al. Milk-Alkali syndrome: A historical review and description of the modern version of the syndrome. Am J Med Sci. 2006; 331: 233-42.
  • 2. Krysiak R, Handzlik-Orlik G, Okopien B. Humoral hypercalcemia of malignancy in a patient with hypoparathyroidism. Eur Rev Med Pharmacol Sci. 2012;16(8):1127-9
  • 3. De Rosa G, Testa A, Giacomini D, Liverotti J, Salvi G, Cefaro GA. Alternation of hypo- and hypercalcemia in a parathyroidectomized patient with breast cancer. Horm Res. 1995;43(5):210-2
  • 4. Sundaresh V, Levine SN. From hypocalcemia to hypercalcemia- an unusual clinical presentation of a patient with permanent postsurgical hypoparathyroidism. J ClinEndocrinolMetab. 2015;100(1):21-4.
  • 5. Kondo S, Tamura K, Makino S, Yokota T, Ishikawa E, Katakami H, Kohari S. A patient with primary hypoparathyroidism developing hypercalcemi aassociated with adult T-cell leukemia/lymphoma. Leuk Lymphoma. 1994;14(5-6):521-5.
  • 6. Mitchell TH, Stamp TC, Jenkins MV, Mawer EB, Berry JL. Hypercalcaemic sarcoidosis in hypoparathyroidism. Br Med J (ClinResEd). 1983;286(6367):764-5.
  • 7. Dockrell DH, Poland GA. Hypercalcemia in a patient with hypoparathyroidism and Nocardiaa steroides infection: a novel observation. Mayo ClinProc. 1997;72(8):757-60.
  • 8. Ito O, Kohzuki M, Nakajima I, Sato K, Nomura T, Kudo K, Ito S.[Thiazide-induced hypercalcemic nephropathy in a patient with secondary hypoparathyroidism]. NihonNaikaGakkaiZasshi. 2004;93(7):1448-50.Japanese.
  • 9. Hepburn NC, Abdul-Aziz LA, Whiteoak R. Danazol-inducedhypercalcaemia in alphacalcidol-treated hypoparathyroidism. Postgrad Med J. 1989;65(769):849-50.
  • 10. Schroth M, Dötsch J, Dörr HG. Hypercalcemia and idiopathic hypoparathyroidism. J Clin Pharm Ther. 2001;26(6):453-5.
  • 11. Boots JM, Burghouts JT, Jansen JL. Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol. Neth J Med. 1999;54(1):16-20.
  • 12. Caplan RH, Beguin EA. Hypercalcemia in a calcitriol-treated hypoparathyroid woman during lactation. Obstet Gynecol. 1990;76(3 Pt 2):485-9.
  • 13. Caplan RH, Wickus GG. Reduced calcitriol requirements for treating hypoparathyroidism during lactation. A case report. J Reprod Med. 1993;38(11):914-8.
  • 14. Cathébras P, Cartry O, Sassolas G, Rousset H. [Hypercalcemia induced by lactation in 2 patients with treated hypoparathyroidism]. RevMed Interne.1996;17(8):675-6. Review. French.
  • 15. Walker DA, Davies M. Addison's disease presenting as a hypercalcemic crisis in a patient with idiopathic hypoparathyroidism. Clin Endocrinol (Oxf). 1981;14(4):419-23.
  • 16. Verbeelen D, Fuss M. Hypercalcaemia induced by oestrogen withdrawal in vitamin D-treated hypoparathyroidism. Br Med J. 1979 Feb 24;1(6162):522-3.
  • 17. Felsenfeld AJ, Levine BS. Milk alkali syndrome and the dynamics of calcium homeostasis. Clin J Am Soc Nephrol 2006;1:641-54.
  • 18. Satoh F, Okado T, Iwamoto M, Akita W, Wakabayashi M, Ohta A, et al. Calcium-alkali syndrome-lik symptoms manifested by daily alphacalcidol and thiazide. Intern Med. 2010;49:837-40.

Life-threatening Hypercalcemia in a Patient with Hypoparathyroidism

Yıl 2017, Cilt: 22 Sayı: 3, 200 - 203, 25.09.2017
https://doi.org/10.21673/anadoluklin.320722

Öz

Milk-alkali syndrome was first described in patients using high dose antacid drugs for peptic
ulcer. The triad of the syndrome is hypercalcemia, metabolic alkalosis, and acute renal failure.
The incidence of the syndrome that decreased after the development of modern ulcer treatments
has currently been increasing again due to the use of calcium-containing medicine for
osteoporosis and renal osteodystrophy. In this report, we present a patient who had been under
calcium carbonate and active vitamin D treatment due to idiopathic hypoparathyroidism and
presented with life-threatening hypercalcemia, metabolic alkalosis, and acute renal failure.

Kaynakça

  • 1. Beall DP, Hensiee HB, Webb HR et al. Milk-Alkali syndrome: A historical review and description of the modern version of the syndrome. Am J Med Sci. 2006; 331: 233-42.
  • 2. Krysiak R, Handzlik-Orlik G, Okopien B. Humoral hypercalcemia of malignancy in a patient with hypoparathyroidism. Eur Rev Med Pharmacol Sci. 2012;16(8):1127-9
  • 3. De Rosa G, Testa A, Giacomini D, Liverotti J, Salvi G, Cefaro GA. Alternation of hypo- and hypercalcemia in a parathyroidectomized patient with breast cancer. Horm Res. 1995;43(5):210-2
  • 4. Sundaresh V, Levine SN. From hypocalcemia to hypercalcemia- an unusual clinical presentation of a patient with permanent postsurgical hypoparathyroidism. J ClinEndocrinolMetab. 2015;100(1):21-4.
  • 5. Kondo S, Tamura K, Makino S, Yokota T, Ishikawa E, Katakami H, Kohari S. A patient with primary hypoparathyroidism developing hypercalcemi aassociated with adult T-cell leukemia/lymphoma. Leuk Lymphoma. 1994;14(5-6):521-5.
  • 6. Mitchell TH, Stamp TC, Jenkins MV, Mawer EB, Berry JL. Hypercalcaemic sarcoidosis in hypoparathyroidism. Br Med J (ClinResEd). 1983;286(6367):764-5.
  • 7. Dockrell DH, Poland GA. Hypercalcemia in a patient with hypoparathyroidism and Nocardiaa steroides infection: a novel observation. Mayo ClinProc. 1997;72(8):757-60.
  • 8. Ito O, Kohzuki M, Nakajima I, Sato K, Nomura T, Kudo K, Ito S.[Thiazide-induced hypercalcemic nephropathy in a patient with secondary hypoparathyroidism]. NihonNaikaGakkaiZasshi. 2004;93(7):1448-50.Japanese.
  • 9. Hepburn NC, Abdul-Aziz LA, Whiteoak R. Danazol-inducedhypercalcaemia in alphacalcidol-treated hypoparathyroidism. Postgrad Med J. 1989;65(769):849-50.
  • 10. Schroth M, Dötsch J, Dörr HG. Hypercalcemia and idiopathic hypoparathyroidism. J Clin Pharm Ther. 2001;26(6):453-5.
  • 11. Boots JM, Burghouts JT, Jansen JL. Unaccountable severe hypercalcemia in a patient treated for hypoparathyroidism with dihydrotachysterol. Neth J Med. 1999;54(1):16-20.
  • 12. Caplan RH, Beguin EA. Hypercalcemia in a calcitriol-treated hypoparathyroid woman during lactation. Obstet Gynecol. 1990;76(3 Pt 2):485-9.
  • 13. Caplan RH, Wickus GG. Reduced calcitriol requirements for treating hypoparathyroidism during lactation. A case report. J Reprod Med. 1993;38(11):914-8.
  • 14. Cathébras P, Cartry O, Sassolas G, Rousset H. [Hypercalcemia induced by lactation in 2 patients with treated hypoparathyroidism]. RevMed Interne.1996;17(8):675-6. Review. French.
  • 15. Walker DA, Davies M. Addison's disease presenting as a hypercalcemic crisis in a patient with idiopathic hypoparathyroidism. Clin Endocrinol (Oxf). 1981;14(4):419-23.
  • 16. Verbeelen D, Fuss M. Hypercalcaemia induced by oestrogen withdrawal in vitamin D-treated hypoparathyroidism. Br Med J. 1979 Feb 24;1(6162):522-3.
  • 17. Felsenfeld AJ, Levine BS. Milk alkali syndrome and the dynamics of calcium homeostasis. Clin J Am Soc Nephrol 2006;1:641-54.
  • 18. Satoh F, Okado T, Iwamoto M, Akita W, Wakabayashi M, Ohta A, et al. Calcium-alkali syndrome-lik symptoms manifested by daily alphacalcidol and thiazide. Intern Med. 2010;49:837-40.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm OLGU SUNUMU
Yazarlar

Hüseyin Karaaslan

Mehmet Nuri Turan Bu kişi benim

Mehmet Ali Eren

Tevfik Sabuncu

Yayımlanma Tarihi 25 Eylül 2017
Kabul Tarihi 17 Ağustos 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 22 Sayı: 3

Kaynak Göster

Vancouver Karaaslan H, Turan MN, Eren MA, Sabuncu T. Life-threatening Hypercalcemia in a Patient with Hypoparathyroidism. Anadolu Klin. 2017;22(3):200-3.

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