Postmenopozal Osteoporozda Laktasyon ve İlk Gestasyonel Yaşın Etkisi

Yıl 2018, Cilt: 23 Sayı: 1, 42 - 47, 29.01.2018

Nilgün Şenol Güler , Gültekin Adanas Aydın , İsmihan Gürgen

https://doi.org/10.21673/anadoluklin.348820

Öz

Amaç: Postmenopozal osteoporozun (OP)
etyolojisinde çeşitli faktörler öne sürülmüştür. Bu çalışma, postmenopozal OP'de
gebelik sayısı, emzirme ve ilk gebelik yaşının etkisini araştırmayı
amaçlamaktadır.

Yöntemler: Nisan-2015 ve Aralık 2015 yılları
arasında 45-70 yaş arası toplam postmenopozal 427 hasta OP taramasına alındı. Tüm
hastalara yaş, boy, kilo, menopoz ve menarş yaşları, kronik hastalıklar, eşlik
eden ilaçlar, aile öyküsü, postmenopozal hormon tedavisi, gebelik sayısı, doğum
sırasındaki yaşlarını ve her gebelikteki laktasyon dönemini içeren bir anket uygulandı. Kemik mineral yoğunluğu (KMY), dual
enerjili X-ray absorbsiyometri kullanılarak ölçüldü; femur boyun, femur total ,
L1-L4 ve L2-L4 değerleri kaydedildi . Hastalar OP (n = 73) ve OP olmayan grup (n
= 354)  olarak ikiye ayrıldı.

Sonuçlar: Gebelik sayısı OP grubunda OP olmayan
gruba göre istatistiksel olarak daha yüksekti (p = 0.037). Gruplar arasında  nulliparite,
primiparite ve multipariteye göre anlamlı fark yoktu.

Tartışma: Çalışmamızın
sonuçları, laktasyon dönemi ve ilk gebelik yaşının postmenopozal OP gelişiminde
bir etkisinin olmadığını göstermektedir.

Anahtar Kelimeler

Osteoporoz, post-menopozal, emzirme, ; gestasyonel yaş

The Effect of Lactation and First Gestational Age on Postmenopausal Osteoporosis

Öz

Objective:
Several factors have been suggested in the etiology of postmenopausal
osteoporosis (OP). This study aims to investigate the effect of number of pregnancies, lactation, and
first gestational age on postmenopausal OP.

Methods: A total of 427 postmenopausal patients
between 45 and 70 years of age who underwent OP scan between April 2015
and December 2015 were included. A questionnaire was administered to all
patients to obtain data including age, height, weight, menopause and menarche
ages, chronic illnesses, concomitant medications, family history,
postmenopausal hormone therapy, number of pregnancies, ages at birth, and
lactation periods at each pregnancy. The bone mineral density (BMD) was
measured using dual-energy X-ray absorptiometry from femoral neck and total
femur and from the lumbar vertebrae L1-L4 and L2-L4 were recorded. The patients
were divided into two groups as those with OP (n=73) and those without OP
(n=354).

Results:
The number of
pregnancies was statistically higher in the OP group, compared to the non-OP
group (p=0.037). According to the nulliparity, primiparity, and multiparity,
there was no significant difference between the groups.

 Conclusion: Our study results suggest that lactation
period and first gestational age have no effect in the development of postmenopausal OP.

Anahtar Kelimeler

Osteoporosis, post-menopausal, lactation, gestational age

Kaynakça

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