Covid-19 Pandemic and Neurological Manifestations

Yıl 2020, Sayı: Special Issue on COVID 19, 246 - 251, 20.03.2020

Ruken Şimşekoğlu Temel Tombul

https://doi.org/10.21673/anadoluklin.738020

Cited By: 1

Öz

A new corona virus outbreak (Corona virus disease, 2019, Covid-19), which started in December in Wuhan province of China, has been confirmed, and the virus spread to the whole world, creating a strong and serious pandemic.
Symptoms such as fever, cough, respiratory distress, diarrhea, and fatigue associated with Covid-19 are typical clinical findings. Some COVID‐19 patients also expressed neurologic findings like headache, dizziness, impaired consciousness, encephalitis, encephalopathy, cerebrovascular diseases, and peripheral nervous system damage. In some of these patients, the SARS-CoV-2 virus was isolated in the cerebrospinal fluid, in some cases, virus was detected in autopsy materials. In this review, the neurological signs and symptoms seen in Covid-19 infected patients and the mechanisms of the virus causing neuronal damage will be discussed.

Anahtar Kelimeler

Covid-19, SARS-CoV-2, neurological signs

Covid-19 Pandemisi ve Nörolojik Tutulumlar

Öz

Çin’in Wuhan eyaletinde Aralık ayında başlayan yeni bir korona virüs salgını (Corona virüs hastalığı-2019, Covid-19) doğrulandı ve virüs tüm Dünya’ya yayılarak güçlü ve ciddi bir pandemi oluşturdu. Covid-19’a bağlı görülen ateş, öksürük, solunum sıkıntısı, ishal, yorgunluk gibi semptomlar tipik klinik bulguları oluşturmaktadır. Bazı hastalarda ise baş ağrısı, dizziness, bilinç bozukluğu, ensefalit, ensefalopati, serebrovasküler hastalıklar, periferik sinir sistemi hasarları gibi nörolojik bulguların saptandığı bilinmektedir. Bu hastaların bir kısmında beyin omurilik sıvısında SARS-CoV-2 virüsü izole edilmiştir, bazı vakalarda ise otopsi materyallerinde virüs saptanmıştır. Bu derlemede Covid-19 ile enfekte hastalarda görülebilecek nörolojik belirti ve bulgular ve virüsün nöronal hasar yapabilme mekanizmaları tartışılacaktır.

Anahtar Kelimeler

Covid-19, SARS-CoV-2, nörolojik belirtiler

Kaynakça

• Zhu N, Zhang D, Wang W, et al. A Novel Coronavirus from Patients with Pneumonia in China N Engl J Med.. 2019. 2020;727–33.
• Lu R, Zhao X, Li J et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. 2020;395(10224):565–74.
• https://www.who.int/emergencies/diseases/novel-coronavirus-2019.
• Hassan SA, Sheikh FN, Jamal S, et al. Coronavirus ( COVID-19 ): A Review of Clinical Features , Diagnosis , and Treatment. 2020;12(3).
• Chen Q, Zheng Z, Zhang C, Zhang X, Wu H, Wang J. Clinical characteristics of 145 patients with corona virus disease 2019 ( COVID ‑ 19 ) in Taizhou , Zhejiang , China. Infection. 2020; April 28;1-9
• Mao L, Jin H, Wang M et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020; published online
• Big M. Neurological manifestations in COVID-19 caused by. CNS Neurosci There. 2020 May;26(5):499-501
• Lofy KH, Wiesman J, Bruce H et al. First Case of 2019 Novel Coronavirus in the United States. N Engl J Med.. 2020;929–36.
• Paniz-mondolfi A, Bryce C, Grimes Z et al. Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2). April 2020; published online.
• Baig AM, Khaleeq A, Ali U et al. Evidence of the COVID-19 Virus Targeting the CNS : Tissue Distribution , Host − Virus Interaction , and Proposed Neurotropic Mechanisms. ACS Chem. Neurosci. 2020, 11, 995−998
• Das G, Mukherjee N, Ghosh S. Neurological Insights of COVID-19 Pandemic. ACS Chem. Neurosci. 2020, published online.
• Rao HCY. The emergence of a novel coronavirus ( SARS ‐ CoV ‐ 2 ) disease and their neuroinvasive propensity may affect in COVID ‐ 19 patients. J Med Virol. 2020 April 22. Online ahead of print.
• Natalie S, Oliveria V, Calabrese P et al. Does SARS-Cov-2 invade the brain? Translational lessons from animal models. E J Neurol. 2020 Apr 25. Online ahead of print.
• Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS ‐ CoV2 may play a role in the respiratory failure of COVID ‐ 19 patients. J Med Virol. 2020 Feb 27. Online ahead of print.
• Wu Y, Xu X, Chen Z et al. Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain Behav Immun. 2020 Mar. Online ahead of print. Eur J Neurol. 2020 Apr 22. Online ahead of print.
• Baig AM, Khaleeq A, Ali u et al. Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem. Neurosci. 2020, 11,7, 995-998.
• Asadi-pooya AA, Simon L. Central Nervous System Manifestations of COVID-19: A Systematic Review. J Neurol Sci. 2020 Apr 11;413:116832.
• Beltrán-Corbellini A, Chico-García JL, Martínez-Poles J et al. Acute-onset smell and taste disorders in the context of Covid-19: a pilot multicenter PCR- based case-control study. Eur J Neurol. 2020 Apr. Online ahead of print.
• Avula A, Nalleballe K, Narula N et al. Brain , Behavior , and Immunity COVID-19 presenting as stroke. Brain Behav Immun. 2020 Apr. Online aheah of print.
• Filatov A, Sharma P, Hindi F, et al. Neurological Complications of Coronavirus Disease ( COVID-19 ): Encephalopathy. Cureus. 2020;12(3).
• Li M, Wang M, Zhou Y et al. The Lancet. Acute cerebrovascular disease following COVID-19 : a single center , retrospective , observational study. 2020;19.
• Herman C, Mayer K, Narwal A. Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19. Neurology. 2020 Apr 28;10. Online ahead of print.
• Lechien JR, Chiesa-Estomba CM, Place S et al. Clinical and Epidemiological Characteristics of 1,420 European Patients with mild-to-moderate Coronavirus Disease 2019. J Intern Med. 2020;0–2.
• Liu K, Pan M, Xiao Z, et al. Neurological manifestations of thecoronavirus(SARS-CoV-2) pandemic 2019–2020. J Neurol Neurosurg Psychiatry. 2020 Apr. epub ahead of print.
• Moriguchi T, Harii N, Goto J et al. A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis [Internet]. 2020;94:55–8.
• Davies NWS, Sharief MK, Howard RS. Infection-associated encephalopathies-their investigation, diagnosis, and treatment. J Neurol. 2006;253(7):833–45.
• COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features. Radiology. 2020 Mar 31;201187. Online ahead of print.
• Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young. N Engl J Med. 2020 Apr. Online ahead of print.
• Sharma D, Rasmussen M, Han R et al. Anesthetic Management of Endovascular Treatment of Acute Ischemic Stroke During COVID-19 Pandemic: Consensus Statement From Society for Neuroscience in Anesthesiology & Critical Care (SNACC)_Endorsed by Society of Vascular & Interventional Neurology (SVIN), Society of NeuroInterventional Surgery (SNIS), Neurocritical Care Society (NCS), and European Society of Minimally Invasive Neurological Therapy (ESMINT). J Neurosurg Anesthesia. 2020 Apr. Online ahead of print.
• Khosravani H, Rjendram P, Ontario L et al. Protected Code Stroke: Hyperacute Stroke Management During the Coronavirus Disease 2019 (COVID-19) Pandemic. Stroke. 2020 Apr 1;STROKEAHA120029838. Online ahead of print.
• Wan Y, Cao S, Fang Q, et al. Coronavirus disease 2019 complicated with Bell ’ s palsy : a case report. Res Sq. 2020;1–7.
• Dinkin M, Gao V, Mbbs JK et al. COVID-19 presenting with ophthalmoparesis from cranial nerve palsy. Neurology. 2020 May. Online ahead of print.
• Zhao H, Shen D, Zhou H et al. Guillain-Barré syndrome associated with SARS-CoV-2 infection : causality or coincidence ? Lancet Neurol [Internet]. 2019;19(5):383–4.
• Gutiérrez-Ortiz C, Méndez A, Rodrigo-Rey S et al. Miller Fisher Syndrome and polyneuritis cranialis in COVID-19. Neurology. 2020;241:10.1212.
• Virani A, Rabold E, Hanson T et al. Guillain-Barré Syndrome associated with SARS-CoV-2 infection. IDCases [Internet]. 2020;20:e00771.
• Camdessanche JP, Morel J, Pozzetto B et al. COVID-19 may induce Guillain–Barré syndrome. Rev Neurol (Paris). 2020;3–5.