Derleme
BibTex RIS Kaynak Göster

Demans ile Temporal Lob Epilepsisi Arasındaki İlişki

Yıl 2021, Cilt: 26 Sayı: 3, 308 - 317, 27.09.2021
https://doi.org/10.21673/anadoluklin.781043

Öz

Temporal lob epilepsisi ve Alzheimer hastalığı (AH), hipokampus ve meziyal temporal yapılarda benzer bir fizyopatoloji sergiler. Her iki hastalıkta da klinik bulgulardan önce nöral ağ değişiklikleri mevcuttur. İki antite arasındaki bu benzerlik nedeniyle, çeşitli çalışmalarda nöbetler ve bunama arasında nasıl bir ilişki olduğu araştırılmıştır. Bu çalışmada ise, meziyal temporal sklerozlu bireylerin demansa daha yatkın olup olmadığı ve AH’nin epilepsiye yol açıp açmadığı sorularına cevap aranmıştır. Bu doğrultuda, biri uzun yıllardır epilepsi tedavisi görmekteyken demans tanısı alan, diğerine ise aynı anda hem epilepsi hem demans tanısı konan yetmişli yaşlardaki iki hastanın klinik bulguları ele alınmıştır. Diğer bir konu olarak da, AH’de nöbet görülme olasılığının oldukça yüksek olmasından doğan AH’nin nöbetlere yol açıp açmadığı sorusu ve bunun kognitif yıkımla olan ilişkisi, çeşitli çalışmalardan veriler ışığında tartışılmıştır. Ayrıca bu ilişki hızlanmış unutma ve konsolidasyon bağlamında da ele alınmıştır.

Kaynakça

  • Chin J, Scharfman HE. Shared cognitive and behavioral impairments in epilepsy and Alzheimer’s disease and potential underlying mechanisms. Epilepsy Behav. 2013;26(3):343–51.
  • Horváth A, Szűcs A, Barcs G, Noebels JL, Kamondi A. Epileptic seizures in Alzheimer disease: a review. Alzheimer Dis Assoc Disord. 2016;30(2):186–92.
  • Palop JJ, Mucke L. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci. 2016;17(12):777–92.
  • Tai XY, Koepp M, Duncan JS, Fox N, Thompson P, Baxendale S, ve ark. Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections. Brain J Neurol. 2016;139(9):2441–55.
  • Leverenz JB, Agustin CM, Tsuang D, Peskind ER, Edland SD, Nochlin D, ve ark. Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study. Arch Neurol. 2002;59(7):1099–106.
  • Onyike CU, Pletnikova O, Sloane KL, Sullivan C, Troncoso JC, Rabins PV. Hippocampal sclerosis dementia: an amnesic variant of frontotemporal degeneration. Dement Neuropsychol. 2013;7(1):83–7.
  • Probst A, Taylor KI, Tolnay M. Hippocampal sclerosis dementia: a reappraisal. Acta Neuropathol. 2007;114(4):335–45.
  • Tai XY, Bernhardt B, Thom M, Thompson P, Baxendale S, Koepp M, ve ark. Review: neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: clinical, pathological and neuroimaging evidence. Neuropathol Appl Neurobiol. 2018;44(1):70–90.
  • Sen A, Capelli V, Husain M. Cognition and dementia in older patients with epilepsy. Brain J Neurol. 2018;141(6):1592–608.
  • Helmstaedter C, Witt JA. Epilepsy and cognition—a bidirectional relationship? Seizure. 2017;49:83–9. Subota A, Pham T, Jetté N, Sauro K, Lorenzetti D, Holroyd-Leduc J. The association between dementia and epilepsy: a systematic review and meta-analysis. Epilepsia. 2017;58(6):962–72.
  • Höller Y, Trinka E. What do temporal lobe epilepsy and progressive mild cognitive impairment have in common? Front Syst Neurosci. 2014;8:58.
  • Breuer LEM, Boon P, Bergmans JWM, Mess WH, Besseling RMH, de Louw A, ve ark. Cognitive deterioration in adult epilepsy: does accelerated cognitive ageing exist? Neurosci Biobehav Rev. 2016;64:1–11.
  • Martin R, Griffith HR, Sawrie S, Knowlton R, Faught E. Determining empirically based self-reported cognitive change: development of reliable change indices and standardized regression-based change norms for the multiple abilities self-report questionnaire in an epilepsy sample. Epilepsy Behav. 2006;8(1):239–45.
  • Jokeit H, Ebner A. Long term effects of refractory temporal lobe epilepsy on cognitive abilities: a cross sectional study. J Neurol Neurosurg Psychiatry. 1999;67(1):44–50.
  • Hermann B, Seidenberg M, Lee EJ, Chan F, Rutecki P. Cognitive phenotypes in temporal lobe epilepsy. J Int Neuropsychol Soc. 2007;13(1):12–20.
  • van Duijn CM, Stijnen T, Hofman A. Risk factors for Alzheimer’s disease: overview of the EURODEM collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol. 1991;20(ek 2):S4–12.
  • Helmstaedter C, Elger CE. Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease? Brain J Neurol. 2009;132(10):2822–30.
  • Baxendale S, Heaney D, Thompson PJ, Duncan JS. Cognitive consequences of childhood-onset temporal lobe epilepsy across the adult lifespan. Neurology. 2010;75(8):705–11.
  • Sen A, Jette N, Husain M, Sander JW. Epilepsy in older people. Lancet. 2020;395(10225):735–48.
  • Butler CR, Zeman AZ. Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment. Brain J Neurol. 2008;131(9):2243–63.
  • Elliott G, Isaac CL, Muhlert N. Measuring forgetting: a critical review of accelerated long-term forgetting studies. Cortex. 2014;54(100):16–32.
  • Baker J, Zeman A. Accelerated long-term forgetting in epilepsy—and beyond. Erişim: https://link.springer.com/chapter/10.1007/978-3-319-45066-7_24.
  • Weston PSJ, Nicholas JM, Henley SMD, Liang Y, Macpherson K, Donnachie E, ve ark. Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer’s disease: a cross-sectional study. Lancet Neurol. 2018;17(2):123–32.
  • Avanzini G, Depaulis A, Tassinari A, de Curtis M. Do seizures and epileptic activity worsen epilepsy and deteriorate cognitive function? Epilepsia. 2013;54(ek 8):14–21.
  • Noebels J. A perfect storm: converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation. Epilepsia. 2011;52(ek 1):39–46.
  • Velez-Pardo C, Arellano JI, Cardona-Gomez P, Del Rio MJ, Lopera F, De Felipe J. CA1 hippocampal neuronal loss in familial Alzheimer’s disease presenilin-1 E280A mutation is related to epilepsy. Epilepsia. 2004;45(7):751–6.
  • Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, ve ark. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013;70(9):1158–66.
  • Rao SC, Dove G, Cascino GD, Petersen RC. Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome. Epilepsy Behav. 2009;14(1):118–20.
  • Cretin B, Sellal F, Philippi N, Bousiges O, Di Bitonto L, Martin-Hunyadi C, ve ark. Epileptic prodromal Alzheimer’s disease, a retrospective study of 13 new cases: expanding the spectrum of Alzheimer’s disease to an epileptic variant? J Alzheimers Dis. 2016;52(3):1125–33.
  • Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, ve ark. Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease. Ann Neurol. 2016;80(6):858–70.
  • Ito M, Echizenya N, Nemoto D, Kase M. A case series of epilepsy-derived memory impairment resembling Alzheimer disease. Alzheimer Dis Assoc Disord. 2009;23(4):406–9.
  • Tombini M, Koch G, Placidi F, Sancesario G, Marciani MG, Bernardi G. Temporal lobe epileptic activity mimicking dementia: a case report. Eur J Neurol. 2005;12(10):805–6.
  • Gaitatzis A, Sisodiya SM, Sander JW. The somatic comorbidity of epilepsy: a weighty but often unrecognized burden. Epilepsia. 2012;53(8):1282–93.
  • Barr WB. Do patients with temporal lobe epilepsy and cognitive decline have Alzheimer’s disease or chronic traumatic encephalopathy (CTE)? Epilepsy Curr. 2017;17(2):96–8.
  • Bandopadhyay R, Liu JYW, Sisodiya SM, Thom M. A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia. Neuropathol Appl Neurobiol. 2014;40(2):177–90.
  • Blass DM, Hatanpaa KJ, Brandt J, Rao V, Steinberg M, Troncoso JC, ve ark. Dementia in hippocampal sclerosis resembles frontotemporal dementia more than Alzheimer disease. Neurology. 2004;63(3):492–7.
  • Lozsadi DA, Chadwick DW, Larner AJ. Late-onset temporal lobe epilepsy with unilateral mesial temporal sclerosis and cognitive decline: a diagnostic dilemma. Seizure. 2008;17(5):473–6.
  • Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, ve ark. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain J Neurol. 2019;142(6):1503–27.
  • Vossel KA, Tartaglia MC, Nygaard HB, Zeman AZ, Miller BL. Epileptic activity in Alzheimer’s disease: causes and clinical relevance. Lancet Neurol. 2017;16(4):311–22.

The Relationship between Dementia and Temporal Lobe Epilepsy

Yıl 2021, Cilt: 26 Sayı: 3, 308 - 317, 27.09.2021
https://doi.org/10.21673/anadoluklin.781043

Öz

Temporal lobe epilepsy and Alzheimer’s disease (AD) are similar in their physiopathology in the hippocampus and mesial temporal structures. In both diseases, there are neural network changes before the clinical manifestations. Considering this similarity between the two entities, the relationship between seizures and dementia has been investigated in various studies. In the present study, we attempt to answer the questions of whether individuals with mesial temporal sclerosis are more likely to develop dementia and whether AD causes epilepsy. With this design, we discuss the clinical findings of two patients in their seventies, of whom one was diagnosed with dementia while under epilepsy treatment for many years and the other received a concurrent diagnosis of epilepsy and dementia. Furthermore, whether AD causes seizures as another question arising from the high probability of seizures in AD and its relationship to cognitive impairment are discussed in the light of data from various studies. This relationship is also discussed in the context of accelerated long-term forgetting and consolidation.

Kaynakça

  • Chin J, Scharfman HE. Shared cognitive and behavioral impairments in epilepsy and Alzheimer’s disease and potential underlying mechanisms. Epilepsy Behav. 2013;26(3):343–51.
  • Horváth A, Szűcs A, Barcs G, Noebels JL, Kamondi A. Epileptic seizures in Alzheimer disease: a review. Alzheimer Dis Assoc Disord. 2016;30(2):186–92.
  • Palop JJ, Mucke L. Network abnormalities and interneuron dysfunction in Alzheimer disease. Nat Rev Neurosci. 2016;17(12):777–92.
  • Tai XY, Koepp M, Duncan JS, Fox N, Thompson P, Baxendale S, ve ark. Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections. Brain J Neurol. 2016;139(9):2441–55.
  • Leverenz JB, Agustin CM, Tsuang D, Peskind ER, Edland SD, Nochlin D, ve ark. Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study. Arch Neurol. 2002;59(7):1099–106.
  • Onyike CU, Pletnikova O, Sloane KL, Sullivan C, Troncoso JC, Rabins PV. Hippocampal sclerosis dementia: an amnesic variant of frontotemporal degeneration. Dement Neuropsychol. 2013;7(1):83–7.
  • Probst A, Taylor KI, Tolnay M. Hippocampal sclerosis dementia: a reappraisal. Acta Neuropathol. 2007;114(4):335–45.
  • Tai XY, Bernhardt B, Thom M, Thompson P, Baxendale S, Koepp M, ve ark. Review: neurodegenerative processes in temporal lobe epilepsy with hippocampal sclerosis: clinical, pathological and neuroimaging evidence. Neuropathol Appl Neurobiol. 2018;44(1):70–90.
  • Sen A, Capelli V, Husain M. Cognition and dementia in older patients with epilepsy. Brain J Neurol. 2018;141(6):1592–608.
  • Helmstaedter C, Witt JA. Epilepsy and cognition—a bidirectional relationship? Seizure. 2017;49:83–9. Subota A, Pham T, Jetté N, Sauro K, Lorenzetti D, Holroyd-Leduc J. The association between dementia and epilepsy: a systematic review and meta-analysis. Epilepsia. 2017;58(6):962–72.
  • Höller Y, Trinka E. What do temporal lobe epilepsy and progressive mild cognitive impairment have in common? Front Syst Neurosci. 2014;8:58.
  • Breuer LEM, Boon P, Bergmans JWM, Mess WH, Besseling RMH, de Louw A, ve ark. Cognitive deterioration in adult epilepsy: does accelerated cognitive ageing exist? Neurosci Biobehav Rev. 2016;64:1–11.
  • Martin R, Griffith HR, Sawrie S, Knowlton R, Faught E. Determining empirically based self-reported cognitive change: development of reliable change indices and standardized regression-based change norms for the multiple abilities self-report questionnaire in an epilepsy sample. Epilepsy Behav. 2006;8(1):239–45.
  • Jokeit H, Ebner A. Long term effects of refractory temporal lobe epilepsy on cognitive abilities: a cross sectional study. J Neurol Neurosurg Psychiatry. 1999;67(1):44–50.
  • Hermann B, Seidenberg M, Lee EJ, Chan F, Rutecki P. Cognitive phenotypes in temporal lobe epilepsy. J Int Neuropsychol Soc. 2007;13(1):12–20.
  • van Duijn CM, Stijnen T, Hofman A. Risk factors for Alzheimer’s disease: overview of the EURODEM collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol. 1991;20(ek 2):S4–12.
  • Helmstaedter C, Elger CE. Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease? Brain J Neurol. 2009;132(10):2822–30.
  • Baxendale S, Heaney D, Thompson PJ, Duncan JS. Cognitive consequences of childhood-onset temporal lobe epilepsy across the adult lifespan. Neurology. 2010;75(8):705–11.
  • Sen A, Jette N, Husain M, Sander JW. Epilepsy in older people. Lancet. 2020;395(10225):735–48.
  • Butler CR, Zeman AZ. Recent insights into the impairment of memory in epilepsy: transient epileptic amnesia, accelerated long-term forgetting and remote memory impairment. Brain J Neurol. 2008;131(9):2243–63.
  • Elliott G, Isaac CL, Muhlert N. Measuring forgetting: a critical review of accelerated long-term forgetting studies. Cortex. 2014;54(100):16–32.
  • Baker J, Zeman A. Accelerated long-term forgetting in epilepsy—and beyond. Erişim: https://link.springer.com/chapter/10.1007/978-3-319-45066-7_24.
  • Weston PSJ, Nicholas JM, Henley SMD, Liang Y, Macpherson K, Donnachie E, ve ark. Accelerated long-term forgetting in presymptomatic autosomal dominant Alzheimer’s disease: a cross-sectional study. Lancet Neurol. 2018;17(2):123–32.
  • Avanzini G, Depaulis A, Tassinari A, de Curtis M. Do seizures and epileptic activity worsen epilepsy and deteriorate cognitive function? Epilepsia. 2013;54(ek 8):14–21.
  • Noebels J. A perfect storm: converging paths of epilepsy and Alzheimer’s dementia intersect in the hippocampal formation. Epilepsia. 2011;52(ek 1):39–46.
  • Velez-Pardo C, Arellano JI, Cardona-Gomez P, Del Rio MJ, Lopera F, De Felipe J. CA1 hippocampal neuronal loss in familial Alzheimer’s disease presenilin-1 E280A mutation is related to epilepsy. Epilepsia. 2004;45(7):751–6.
  • Vossel KA, Beagle AJ, Rabinovici GD, Shu H, Lee SE, Naasan G, ve ark. Seizures and epileptiform activity in the early stages of Alzheimer disease. JAMA Neurol. 2013;70(9):1158–66.
  • Rao SC, Dove G, Cascino GD, Petersen RC. Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome. Epilepsy Behav. 2009;14(1):118–20.
  • Cretin B, Sellal F, Philippi N, Bousiges O, Di Bitonto L, Martin-Hunyadi C, ve ark. Epileptic prodromal Alzheimer’s disease, a retrospective study of 13 new cases: expanding the spectrum of Alzheimer’s disease to an epileptic variant? J Alzheimers Dis. 2016;52(3):1125–33.
  • Vossel KA, Ranasinghe KG, Beagle AJ, Mizuiri D, Honma SM, Dowling AF, ve ark. Incidence and impact of subclinical epileptiform activity in Alzheimer’s disease. Ann Neurol. 2016;80(6):858–70.
  • Ito M, Echizenya N, Nemoto D, Kase M. A case series of epilepsy-derived memory impairment resembling Alzheimer disease. Alzheimer Dis Assoc Disord. 2009;23(4):406–9.
  • Tombini M, Koch G, Placidi F, Sancesario G, Marciani MG, Bernardi G. Temporal lobe epileptic activity mimicking dementia: a case report. Eur J Neurol. 2005;12(10):805–6.
  • Gaitatzis A, Sisodiya SM, Sander JW. The somatic comorbidity of epilepsy: a weighty but often unrecognized burden. Epilepsia. 2012;53(8):1282–93.
  • Barr WB. Do patients with temporal lobe epilepsy and cognitive decline have Alzheimer’s disease or chronic traumatic encephalopathy (CTE)? Epilepsy Curr. 2017;17(2):96–8.
  • Bandopadhyay R, Liu JYW, Sisodiya SM, Thom M. A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia. Neuropathol Appl Neurobiol. 2014;40(2):177–90.
  • Blass DM, Hatanpaa KJ, Brandt J, Rao V, Steinberg M, Troncoso JC, ve ark. Dementia in hippocampal sclerosis resembles frontotemporal dementia more than Alzheimer disease. Neurology. 2004;63(3):492–7.
  • Lozsadi DA, Chadwick DW, Larner AJ. Late-onset temporal lobe epilepsy with unilateral mesial temporal sclerosis and cognitive decline: a diagnostic dilemma. Seizure. 2008;17(5):473–6.
  • Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, ve ark. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain J Neurol. 2019;142(6):1503–27.
  • Vossel KA, Tartaglia MC, Nygaard HB, Zeman AZ, Miller BL. Epileptic activity in Alzheimer’s disease: causes and clinical relevance. Lancet Neurol. 2017;16(4):311–22.
Toplam 39 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm DERLEME
Yazarlar

Erol Yıldırım 0000-0002-0575-7278

Kübra Soğukkanlı 0000-0002-9855-8859

Lütfü Hanoğlu 0000-0003-4292-5717

Yayımlanma Tarihi 27 Eylül 2021
Kabul Tarihi 3 Ocak 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 26 Sayı: 3

Kaynak Göster

Vancouver Yıldırım E, Soğukkanlı K, Hanoğlu L. Demans ile Temporal Lob Epilepsisi Arasındaki İlişki. Anadolu Klin. 2021;26(3):308-17.

13151 This Journal licensed under a CC BY-NC (Creative Commons Attribution-NonCommercial 4.0) International License.