Correlation of the variations in prevalence of coronavirus disease 2019 and vitamin D receptor gene polymorphisms in cohorts from 26 countries

Yıl 2022, Cilt: 27 Sayı: 1, 60 - 70, 29.01.2022

Lütfiye Karcıoğlu

https://doi.org/10.21673/anadoluklin.987578

Cited By: 1

Öz

Aim: This study aimed to investigate the correlation between the rates of coronavirus disease 2019 (COVID-19) prevalence and mortality and the frequency of vitamin D receptor (VDR) gene polymorphisms at the loci rs7975232 (ApaI), rs1544410 (BsmI), rs2228570 (FokI), and rs731236 (TaqI) in cohorts from 26 countries.

Methods: The study included the use of 26 countries where VDR gene polymorphisms at the loci rs731236 (TaqI), rs7975232 (ApaI), rs2228570 (FokI), and rs1544410 (BsmI) were determined and where the relevant frequencies of alleles in healthy populations were reported: Italy, China, Turkey, Japan, Mexico, Russia, India, Poland, Egypt, Czechia, Ethiopia, Saudi Arabia, Greece, the Netherlands, Korea, Spain, the United States, Pakistan, Nigeria, Lebanon, the Central African Republic, Finland, Iran, Tunisia, Brazil, and Croatia. The COVID-19 prevalence and mortality rates (per million population) reported for each country on 6 December 2020 were recorded.

Results: A significant positive correlation was found between the frequency of AA genotype of rs7975232 and the COVID-19 prevalence (r=0.45, r2=0.20, p=0.02) and mortality (r=0.42, r2=0.17, p=0.03) rates. Twenty percent of the variability in prevalence and 17% of the variability in mortality could be explained by the frequency of AA genotype. Similarly, a significant positive correlation was found between the frequency of TT genotype of rs731236 and the COVID-19 prevalence (r=0.42, r2=0.17, p=0.03) rates. Seventeen percent of the variability in prevalence could be explained by the frequency of TT genotype. The correlations between the frequency of rs1544410 and rs2228570 and the COVID-19 prevalence and mortality were not significant.

Conclusion: The variation in COVID-19 prevalence in the 26 populations included can be explained by the polymorphisms at the rs7975232 (ApaI) and rs731236 (TaqI) loci.

Anahtar Kelimeler

coronavirus disease 2019, correlation, polymorphism, vitamin D receptor

Yirmi altı ülkeden kohortlarda koronavirüs hastalığı 2019 prevalansındaki varyasyonların vitamin D reseptör gen polimorfizmleriyle korelasyonu

Öz

Amaç: Bu çalışmada 26 ülkeden kohortlarda rs7975232 (ApaI), rs1544410 (BsmI), rs2228570 (FokI), rs731236 (TaqI) lokuslarında vitamin D reseptör (VDR) gen polimorfizmi sıklığı ile koronavirüs hastalığı 2019 (COVID-19) prevalans ve mortalite oranları arasındaki korelasyonu araştırmak amaçlanmıştır.

Yöntem: Çalışmada rs7975232 (ApaI), rs2228570 (FokI), rs1544410 (BsmI) ve rs731236 (TaqI) lokuslarında VDR gen polimorfizmleri tanımlanmış ve sağlıklı popülasyonlarda ilgili alel frekansları bildirilmiş 26 ülke kullanıldı: İtalya, Çin, Türkiye, Japonya, Meksika, Rusya, Hindistan, Polonya, Mısır, Çekya, Etiyopya, Suudi Arabistan, Yunanistan, Hollanda, Kore, İspanya, Birleşik Devletler, Pakistan, Nijerya, Lübnan, Orta Afrika Cumhuriyeti, Finlandiya, İran, Tunus, Brezilya ve Hırvatistan. Her ülke için 6 Aralık 2020 tarihinde bildirilen COVID-19 (milyon popülasyonda) prevalans ve mortalite oranları kaydedildi.

Bulgular: rs7975232’nin AA genotipi sıklığı ile COVID-19 prevalans (r=0,45; r2=0,20; p=0,02) ve mortalite (r=0,42; r2=0,17; p=0,03) oranları arasında anlamlı pozitif korelasyon saptandı. Prevalanstaki değişkenliğin %20’si ve mortalitedeki değişkenliğin %17’si AA genotipinin sıklığı ile açıklanabildi. Yine rs731236’nın TT genotipi ile COVID-19 prevalans (r=0,42; r2=0,17; p=0,03) oranları arasında anlamlı pozitif korelasyon saptandı. Prevalanstaki değişkenliğin %17’si TT genotipinin sıklığı ile açıklanabildi. rs1544410 ve rs2228570 sıklığı ile COVID-19 prevalans ve mortalitesi arasındaki korelasyonlar anlamlı değildi.

Sonuç: İncelenen 26 popülasyondaki COVID-19 prevalans varyasyonları rs7975232 ve rs731236 lokuslarındaki polimorfizmler ile açıklanabilir.

Anahtar Kelimeler

D vitamini reseptörü, korelasyon, koronavirüs hastalığı 2019, polimorfizm

Kaynakça

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