Relationship between average vitamin D levels of European countries and COVID-19 case and mortality rates

Yıl 2022, Cilt: 27 Sayı: 2, 127 - 134, 24.05.2022

Lütfiye Karcıoğlu Zeynep Hatice Çöklü

https://doi.org/10.21673/anadoluklin.1019034

Cited By: 1

Öz

Aim: The World Health Organization (WHO) data for Coronavirus Disease-2019 (COVID-19) revealed that the case and mortality rates due to Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) infection are higher in certain countries. Recent data have shown that various factors including the ratios of the elderly population and having chronic diseases, as well as vitamin D deficiency at different levels in populations, may be effective in this condition. It is recommended that vitamin D, known to be effective on the immune and respiratory system functions, should be used as a vitamin supplement with nutrients, especially in the risk group of elderly and chronic patients during the COVID-19 pandemic. The present study was conducted to determine the mean vitamin D levels and their correlations with COVID-19 cases and mortalities per million of each population of 20 European countries (Iceland, Norway, Germany, Sweden, Finland, Netherlands, Denmark, England, Ireland, Italy, Belgium, France, Switzerland, Spain, Estonia,
Czechia, Slovakia, Hungary Portugal, and Turkey).

Methods: A literature review was performed to determine the mean serum 25(OH)D levels of 20 European countries. It was evaluated statistically using the COVID-19 cases and mortality rates per one million population for the dates of November 22, 2020, and January 3, 2021, published by WHO.

Results: There was no significant correlation between the mean vitamin D levels and COVID-19 cases (p=0.08), while a moderately significant negative correlation was found with the COVID-19 mortality rates for 2020 (p=0.05).

Conclusion: Low vitamin D levels among European countries can explain 19% of COVID-19 mortality rates in 2020.

Anahtar Kelimeler

COVID-19, infection;, SARS-CoV-2, vitamin D;, vitamin D supplements

Avrupa ülkelerinin D vitamini ortalama düzeyleri ile COVID-19 vaka ve mortalite oranları arasındaki ilişki

Öz

Amaç: Dünya Sağlık Örgütü (DSÖ)’nün Koronavirüs Hastalığı-2019 (COVID-19) verileri incelendiğinde Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) enfeksiyonuna bağlı vaka ve mortalite oranları bazı ülkelerde daha yüksektir. Son araştırma verileri bu duruma yaşlı nüfus oranı, kronik hastalığa sahip olma gibi çeşitli etkenlerin yanı sıra popülasyonlarda farklı düzeylerde bulunan D vitamini eksikliğinin de etkili olabileceğini göstermiştir. İmmün ve solunum sistemleri fonksiyonları üzerinde etkili olduğu bilinen D vitaminini, COVID-19 pandemisi sürecinde özellikle risk grubundaki yaşlı ve kronik hastaların vitamin takviyesi olarak kullanmaları ve besinlerle desteklenmeleri önerilmektedir. Bu çalışma 20 Avrupa ülkesi (İzlanda, İsveç, Finlandiya, Norveç, Danimarka, Çekya, İngiltere, İrlanda, İtalya, Hollanda, Belçika, Almanya, Fransa, İsviçre, İspanya, Estonya, Slovakya, Macaristan, Portekiz ve Türkiye) ortalama D vitamini düzeylerini belirlemek ve her ülkedeki bir milyon nüfus başına düşen COVID-19 vaka ve mortalite oranları arasındaki ilişkiyi incelemek amacıyla yapılmıştır.

Yöntemler: 20 Avrupa ülkesinin ortalama serum 25(OH)D seviyelerini belirlemek için literatür taraması yapıldı. DSÖ’nün yayınlamış olduğu 22 Kasım 2020 ve 3 Ocak 2021 tarihlerine ait bir milyon nüfus başına düşen COVID-19 vaka ve mortalite oranları kullanılarak istatiksel olarak değerlendirildi.

Bulgular: Araştırmaya dahil edilen ülkelerin ortalama D vitamini seviyeleri ve COVID-19 vakaları arasında anlamlı bir ilişki yokken (p=0,08), 2020 yılına ait COVID-19 mortalite oranları arasında ise negatif yönde, düşük düzeyde (p=0,05) anlamlı bir ilişki olduğu bulunmuştur.

Sonuç: Avrupa ülkeleri arasında 2020 yılı COVID-19 mortalite oranlarının %19’u D vitamini düzeylerinin düşüklüğü ile açıklanabilmektedir.

Anahtar Kelimeler

COVID-19, D vitamini, D vitamini takviyesi, enfeksiyon;, SARS-CoV-2

Kaynakça

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