Antidiabetic Effect of Cinclidotus pachylomoides Bizot (Bryophyta) Extract

Yıl 2024, Cilt: 10 Sayı: 2, 89 - 94, 05.12.2024

Ulaş Değirmenci , Tülay Ezer

https://doi.org/10.26672/anatolianbryology.1544951

Öz

Type 2 diabetes (T2D) is recognized as one of the most important public health problems in all nations in the 21st century. Chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction and failure of various organs. Postprandial hyperglycemia is mainly caused by rapid absorption of glucose in the intestine, where α-glucosidase plays an important role in the hydrolysis of dietary carbohydrates. Inhibition of α-glucosidase is considered as an effective approach in the treatment of type 2 diabetes. Bryophytes are the second largest taxonomic group in the plant kingdom and are an integral part of biodiversity. Recently, a large number of different bioactive substances have been isolated from liverworts and mosses. In this study, the α-glucosidase enzyme inhibition effect of the extract of the moss species Cinclidotus pachylomoides Bizot (Bryophyta), which was characterized for the first time by GK/KS method, was investigated and it was found to have a moderate α-glucosidase enzyme inhibition effect.

Anahtar Kelimeler

Bryophyte, Cinclidotus pachylomoides, mosses, type 2 diabetes, α-glucosidase

Etik Beyan

“Cinclidotus pachylomoides Bizot (Bryophyta) Ekstraktının Antidiyabetik Etkisi” başlıklı çalışmamızda hayvan ya da insan deneyi yapılmadığından etik kurul onayına gerek bulunmamaktadır.

Cinclidotus pachylomoides Bizot (Bryophyta) Ekstraktının Antidiyabetik Etkisi

Öz

Tip 2 diyabet (T2D), 21. yüzyılda tüm uluslarda en önemli halk sağlığı sorunlarından biri olarak kabul edilmektedir. Diyabetin kronik hiperglisemisi, çeşitli organların uzun vadeli hasarı, işlev bozukluğu ve yetmezliği ile ilişkilidir. Postprandiyal hiperglisemi esas olarak bağırsakta glikozun hızlı emiliminden kaynaklanır ve burada α-glukozidaz diyetle alınan karbonhidratların hidrolizinde önemli bir rol oynar. Tip 2 diyabetin tedavisinde α-glukozidaz inhibisyonu etkili bir yaklaşım olarak kabul edilmektedir. Briyofitler, bitkiler aleminin ikinci büyük taksonomik grubu olup biyoçeşitliliğin ayrılmaz bir parçasıdır. Son zamanlarda ciğerotlarından ve karayosunlarından çok sayıda farklı biyoaktif madde izole edilmiştir. Bu çalışmada da GK/KS yöntemiyle ilk kez karakterizasyonu yapılan karayosunu türü Cinclidotus pachylomoides Bizot (Bryophyta) ekstraktının α-glukozidaz enzim inhibisyon etkisi araştırılmış olup orta düzeyde α-glukozidaz enzim inhibisyon etkisi olduğu tespit edilmiştir.

Anahtar Kelimeler

Briyofit, Cinclidotus pachylomoides, karayosunu, tip 2 diyabet, α-glukozidaz

Kaynakça

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