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Comparison of Clinic and Demographic Characteristics of Children with Laboratory-Confirmed and Suspected COVID-19 who Admitted to Pediatric Emergency Clinic

Yıl 2023, Cilt: 6 Sayı: 4, 141 - 147, 29.12.2023
https://doi.org/10.54996/anatolianjem.1252517

Öz

Aim: To determine the frequency of COVID-19 infection in children and to compare the parameters of laboratory-confirmed and suspected cases.

Material and Methods: Medical records collected with a prospective design of 1300 pediatric patients who applied to COVID-19 triage of pediatric emergency service. Clinic and demographic characteristics of children with laboratory-confirmed and suspected COVID-19 were compared. Nasopharyngeal swab sample was taken from all pediatric patients in accordance with the possible case definition determined by the national Ministry of Health.

Results: The COVID-19 test was found positive in 94 (7.2%) children. Of those, 34.5% children had a history of contact, and 31.9% of all cases were asymptomatic. The mean age of children who were positive for COVID-19 was higher than those who were negative (p <0.001). COVID-19 positive cases had a higher domestic contact history than those who were negative (79.8% and 31%, respectively, p <0.001). The mean WBC, platelet, neutrophil, RDW, procalcitonin, CRP, LDH and total bilirubin values of COVID-19 positive patients were found as significantly lower than COVID-19 negative patients (p <0.05).

Conclusion: We found that there was a statistically significant difference between COVID-19 positive and negative patients in terms of age and laboratory parameters. We have shown that most patients with positive COVID-19 test are asymptomatic, have a high rate of contact history and require hospitalization.

Proje Numarası

Yok

Kaynakça

  • Zhu NA, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8): 7
  • World Health Organization. Novel coronavirus (2019-nCoV). Situation report-22 [Internet]. Geneva (Switzerland): World Health Organization; 2020 [cited 2020 Mar 12]. Available from: https://www.who.int/docs/ default-source/coronaviruse/situation-reports/20200211-sitrep-22-ncov.
  • Ludvigsson JF. Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020 Apr 14: doi: 10.1111/apa.15270.
  • Chan JF, Yuan S, Kok KH, To KKW, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223): 514-523.
  • Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of COVID-19 in children in early January 2020 in Wuhan, China. N Engl J Med. 2020;382(14):1370-1371.
  • Choi SH, Kim HW, Kang JM, Kim DH, Cho EY. Epidemiology and clinical features of coronavirus disease 2019 in children. Clin Exp Pediatr. 2020;63(4):125-132.
  • Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J. 2020;39(5):355-368.
  • Republic of Turkey Ministry COVID-19 Information Page. https://covid19.saglik.gov.tr/TR-66301/covid-19-rehberi.html.
  • Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6):e20200702.
  • Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19? J Microbiol Immunol Infect. 2020;53(3):371-372.
  • Mania A, Mazur-Melewska K, Lubarski K, Kuczma-Napierała J, Mazurek J, Jończyk-Potoczna K, et al. Wide spectrum of clinical picture of COVID-19 in children - from mild to severe disease. J Infect Public Health. 2021;14(3):374-379.
  • Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020 Jul 28;71(15):853-857.
  • Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 infection in children. N Engl J Med. 23;382(17):1663-1665.
  • Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: transmission dynamics and clinical characteristics. J Formos Med Assoc 2020;119:670-673.
  • Martins MM, Prata-Barbosa A, da Cunha AJLA. Update on SARS-CoV-2 infection in children. Paediatr Int Child Health. 2021;41(1):56-64.
  • Bozlu G, Ozgokce Ozmen B, Akca M, Durak F, Kuyucu N. The Role of Immature Granulocytes Percentage to Predict Severe COVID-19 in Children. Kuwait Medical Journal, (In press).
  • Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin Chem Lab Med. 2020;58(7):1135-1138.

Çocuk Acil Kliniğine Başvuran Laboratuvarca Doğrulanmış ve Şüpheli COVID-19 Çocukların Klinik ve Demografik Özelliklerinin Karşılaştırılması

Yıl 2023, Cilt: 6 Sayı: 4, 141 - 147, 29.12.2023
https://doi.org/10.54996/anatolianjem.1252517

Öz

Amaç: Çocuklarda COVID-19 enfeksiyonu sıklığını belirlemek ve laboratuvarca doğrulanmış ve şüpheli vakaların parametrelerini karşılaştırmak.

Gereç ve Yöntemler: Çocuk acil servisinin COVID-19 triyajına başvuran 1300 pediatrik hastadan prospektif bir tasarımla toplanan tıbbi kayıtlar alındı. Laboratuvarca doğrulanmış ve COVID-19 şüphesi olan çocukların klinik ve demografik özellikleri karşılaştırıldı. Sağlık Bakanlığı tarafından belirlenen olası vaka tanımına göre tüm pediatrik hastalardan nazofaringeal sürüntü örneği alındı.

Bulgular: 94 (%7,2) çocukta COVID-19 testi pozitif bulundu. Bunların %34,5'inde çocukların temas öyküsü vardı ve tüm vakaların %31,9'u asemptomatiktir. COVID-19 pozitif olan çocukların yaş ortalaması negatif olanlardan daha yüksekti (p <0.001). COVID-19 pozitif vakaların, negatif olanlara göre daha yüksek ev içi temas öyküsü vardı (sırasıyla %79,8 ve %31, p <0,001). COVID 19 pozitif çocuklarda ortalama beyaz kan hücresi, trombosit, nötrofil, kırmızı kan hücresi dağılım genişliği, prokalsitonin, C-reaktif protein, laktat dehidrogenaz ve total bilirubin değerleri istatistiksel olarak anlamlıydı (p <0.05).

Sonuç: Çocuklarda COVID-19 enfeksiyonu oranı nispeten düşüktür ve COVID-19 ile ilişkili bildirilen vaka serileri de pediatrik grupta erişkinlere göre daha azdır. COVID-19'un çocuklarda epidemiyolojik özellikleri ve bulaşma yolları ile ilgili önemli sayıda vaka içeren çalışmalardan biri olduğunu ve bundan sonraki çalışmalara ışık tutacağını düşünüyoruz.

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

Yok

Kaynakça

  • Zhu NA, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8): 7
  • World Health Organization. Novel coronavirus (2019-nCoV). Situation report-22 [Internet]. Geneva (Switzerland): World Health Organization; 2020 [cited 2020 Mar 12]. Available from: https://www.who.int/docs/ default-source/coronaviruse/situation-reports/20200211-sitrep-22-ncov.
  • Ludvigsson JF. Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. 2020 Apr 14: doi: 10.1111/apa.15270.
  • Chan JF, Yuan S, Kok KH, To KKW, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223): 514-523.
  • Liu W, Zhang Q, Chen J, Xiang R, Song H, Shu S, et al. Detection of COVID-19 in children in early January 2020 in Wuhan, China. N Engl J Med. 2020;382(14):1370-1371.
  • Choi SH, Kim HW, Kang JM, Kim DH, Cho EY. Epidemiology and clinical features of coronavirus disease 2019 in children. Clin Exp Pediatr. 2020;63(4):125-132.
  • Zimmermann P, Curtis N. Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. Pediatr Infect Dis J. 2020;39(5):355-368.
  • Republic of Turkey Ministry COVID-19 Information Page. https://covid19.saglik.gov.tr/TR-66301/covid-19-rehberi.html.
  • Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 Among Children in China. Pediatrics. 2020;145(6):e20200702.
  • Lee PI, Hu YL, Chen PY, Huang YC, Hsueh PR. Are children less susceptible to COVID-19? J Microbiol Immunol Infect. 2020;53(3):371-372.
  • Mania A, Mazur-Melewska K, Lubarski K, Kuczma-Napierała J, Mazurek J, Jończyk-Potoczna K, et al. Wide spectrum of clinical picture of COVID-19 in children - from mild to severe disease. J Infect Public Health. 2021;14(3):374-379.
  • Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020 Jul 28;71(15):853-857.
  • Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 infection in children. N Engl J Med. 23;382(17):1663-1665.
  • Cao Q, Chen YC, Chen CL, Chiu CH. SARS-CoV-2 infection in children: transmission dynamics and clinical characteristics. J Formos Med Assoc 2020;119:670-673.
  • Martins MM, Prata-Barbosa A, da Cunha AJLA. Update on SARS-CoV-2 infection in children. Paediatr Int Child Health. 2021;41(1):56-64.
  • Bozlu G, Ozgokce Ozmen B, Akca M, Durak F, Kuyucu N. The Role of Immature Granulocytes Percentage to Predict Severe COVID-19 in Children. Kuwait Medical Journal, (In press).
  • Henry BM, de Oliveira MHS, Benoit S, Plebani M, Lippi G. Laboratory abnormalities in children with novel coronavirus disease 2019. Clin Chem Lab Med. 2020;58(7):1135-1138.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Orijinal Çalışma
Yazarlar

Fatma Durak 0000-0002-2247-6128

Gülçin Bozlu 0000-0002-9089-8912

Asuman Akar 0000-0001-5265-3271

Merve Havan 0000-0003-3431-7906

Berfin Özgökçe Özmen 0000-0001-5054-8507

Necdet Kuyucu 0000-0002-6721-4105

Proje Numarası Yok
Erken Görünüm Tarihi 29 Aralık 2023
Yayımlanma Tarihi 29 Aralık 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 6 Sayı: 4

Kaynak Göster

AMA Durak F, Bozlu G, Akar A, Havan M, Özgökçe Özmen B, Kuyucu N. Comparison of Clinic and Demographic Characteristics of Children with Laboratory-Confirmed and Suspected COVID-19 who Admitted to Pediatric Emergency Clinic. Anatolian J Emerg Med. Aralık 2023;6(4):141-147. doi:10.54996/anatolianjem.1252517