Araştırma Makalesi
BibTex RIS Kaynak Göster

The Effect of Stroke Units on The Management of Ischemic Stroke Patients in the Emergency Department: A Retrospective 5-Year Study

Yıl 2025, Cilt: 8 Sayı: 1, 13 - 18, 29.03.2025
https://doi.org/10.54996/anatolianjem.1564648

Öz

Aim: Ischemic stroke is one of the leading causes of morbidity and mortality Worldwide. It is recommended to treat stroke patients in specialized care centers known as stroke units (SU). The aim of this study is to investigate the impact of the stroke unit on the treatment of stroke patients in the emergency department (ED).

Material and Methods: This retrospective observational study was performed in the emergency department of Dokuz Eylül University Faculty of Medicine Hospital. Patients aged 18 years and over with a diagnosis of ischemic stroke were included in the study. A comparison was made between the demographic characteristics, treatments given, length of stay in the emergency department and hospital, and mortality rates before and after the SU was introduced.

Results: A total of 1,546 patients were included in this study; 583 of the patients were admitted before the SU was established, and 963 were admitted after. The majority of stroke patients (56%) were male. The mean age of patients before the SU was 72±12.4 years and after SU it was 70±12.9 years. The highest number of admissions was observed in the 71-80 age group. The most common symptoms for hospital admission were weakness in arms and legs and dysarthria. Thrombolytic treatment was administered to 1.2% of ischemic stroke patients before the SU and 5.5% after the SU (p=0.00). The mean hospital length of stay was 10.7±8.3 days before the SU and 9.4±8.3 days after. Mortality was 8.6% before the SU and 6.7% after.

Conclusion: The establishment of the Stroke Unit (SU) resulted in an increased rate of thrombolytic treatment. In thisstudy SU had no effect on mortality. Despite the increase in the number of patients, there was no change in the length of stay in the ED; however, hospital length of stay was shortened.

Etik Beyan

All authors declared that they comply with the Research and Publication Ethics rules. (Ethics committee mediation, approval date, and number: Dokuz Eylul University Hospital, Izmir, 13.01.2011; 2011/01-08) Identity information was not requested from the participants in accordance with the purpose of the study and on the basis of the confidentiality principle.

Destekleyen Kurum

This research received no specific grant from any funding agency in the public, commercial, or notfor-profit sectors.

Kaynakça

  • Feigin VL, Brainin M, Norrving B, et al. World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. International Journal of Stroke. 2022;17(1):18-29. doi:10.1177/17474930211065917
  • World Health Organization. Health statistics of Türkiye. 2019. Available at: https://data.who.int/countries/792. Accessed 08 September 2024.
  • Türkiye Istatistik Kurumu. Health statistics of 2019. Available at: https://data.tuik.gov.tr/Kategori/GetKategori?p=nufus-ve-demografi109&dil=1. Accessed 10 September 2024.
  • World Health Organization. Cerebrovascular Disorders: A Clinical and Research Classification.1978. WHO offset Publication no:43.
  • Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2021;52(7). doi:10.1161/STR.0000000000000375
  • Langhorne P. The Stroke Unit Story: Where Have We Been and Where Are We Going? Cerebrovasc Dis. 2021;50(6):636-643. doi:10.1159/000518934
  • Garraway WM, Akhtar AJ, Prescott RJ, Hockey L. Management of acute stroke in the elderly: preliminary results of a controlled trial. Br Med J. 1980;280(6220):1040-1043. doi:10.1136/bmj.280.6220.1040
  • Indredavik B, Bakke F, Solberg R, Rokseth R, Haaheim LL, Holme I. Benefit of a stroke unit: a randomized controlled trial. Stroke. 1991;22(8):1026-1031. doi:10.1161/01.str.22.8.1026
  • Rønning OM, Guldvog B. Stroke units versus general medical wards, I: twelve- and eighteen-month survival: a randomized, controlled trial. Stroke. 1998;29(1):58-62. doi:10.1161/01.str.29.1.58
  • Langhorne P, Ramachandra S, Stroke Unit Trialists’ Collaboration. Organised inpatient (stroke unit) care for stroke: network metaanalysis. Cochrane Database Syst Rev. 2020;4(4):CD000197. doi:10.1002/14651858.CD000197.pub4
  • Sun Y, Paulus D, Eyssen M, Maervoet J, Saka O. A systematic review and meta-analysis of acute stroke unit care: what’s beyond the statistical significance? BMC Med Res Methodol. 2013;13:132. doi:10.1186/1471-2288-13-132
  • Kumral E, Ozkaya B, Sagduyu A, Sirin H, Vardarli E, Pehlivan M. The Ege Stroke Registry: a hospital-based study in the Aegean region, Izmir, Turkey. Analysis of 2,000 stroke patients. Cerebrovasc Dis. 1998;8(5):278-288. doi:10.1159/000015866
  • Bornstein NM, Aronovich BD, Karepov VG, et al. The Tel Aviv Stroke Registry. 3600 consecutive patients. Stroke. 1996;27(10):1770-1773. doi:10.1161/01.str.27.10.1770
  • Bousser MG, Amarenco P, Chamorro A, et al. The Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic attack (PERFORM) study: baseline characteristics of the population. Cerebrovasc Dis. 2009;27(6):608-613. doi:10.1159/000216835
  • Centers for Disease Control and Prevention (CDC). Annual smokingattributable mortality, years of potential life lost, and productivity losses--United States, 1997-2001. MMWR Morb Mortal Wkly Rep. 2005;54(25):625-628.
  • Rey V, Faouzi M, Huchmand-Zadeh M, Michel P. Stroke initial severity and outcome relative to insurance status in a universal health care system in Switzerland. Eur J Neurol. 2011;18(8):1094-1097. doi:10.1111/j.1468-1331.2010.03264.x
  • Bai X, Li Z, Cai Z, Yao M, Chen L, Wang Y. Gender differences in risk factors for ischemic stroke: a longitudinal cohort study in East China. BMC Neurol. 2024;24(1):171. doi:10.1186/s12883-024-03678-0
  • Kim HJ, Ahn JH, Kim SH, Hong ES. Factors associated with prehospital delay for acute stroke in Ulsan, Korea. J Emerg Med. 2011;41(1):59-63. doi:10.1016/j.jemermed.2010.04.001
  • Yanagida T, Fujimoto S, Inoue T, Suzuki S. Prehospital delay and strokerelated symptoms. Intern Med. 2015;54(2):171-177. doi:10.2169/internalmedicine.54.2684
  • Revathi S, Kavitha MS, Shankar V. Factors Associated with Prehospital Delay in Patients with Acute Stroke in South India. Indian J Community Med. 2023;48(1):82-90. doi:10.4103/ijcm.ijcm_213_22
  • Keskin O, Kalemoğlu M, Ulusoy RE. A clinic investigation into prehospital and emergency department delays in acute stroke care. Med Princ Pract. 2005;14(6):408-412. doi:10.1159/000088114
  • Korkmaz T, Ersoy G, Kutluk K, et al. An Evaluation of Pre-Admission Factors Affecting the Admission Time of Patients with Stroke Symptoms. . Turk J Emerg Med . 2010;10:106-111.
  • Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM. Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. Neurology. 2001;56(8):1015-1020. doi:10.1212/wnl.56.8.1015
  • Lattimore SU, Chalela J, Davis L, et al. Impact of establishing a primary stroke center at a community hospital on the use of thrombolytic therapy: the NINDS Suburban Hospital Stroke Center experience. Stroke. 2003;34(6):e55-7. doi:10.1161/01.STR.0000073789.12120.F3
  • Gillum LA, Johnston SC. Characteristics of academic medical centers and ischemic stroke outcomes. Stroke. 2001;32(9):2137-2142. doi:10.1161/hs0901.094260
  • Rocha MSG, Almeida ACF, Abath Neto O, Porto MPR, Brucki SMD. Impact of stroke unit in a public hospital on length of hospitalization and rate of early mortality of ischemic stroke patients. Arq Neuropsiquiatr. 2013;71(10):774-779. doi:10.1590/0004- 282X20130120
  • Chan DKY, Cordato D, O’Rourke F, et al. Comprehensive stroke units: a review of comparative evidence and experience. Int J Stroke. 2013;8(4):260-264. doi:10.1111/j.1747-4949.2012.00850.x
  • Foley N, Salter K, Teasell R. Specialized stroke services: a meta-analysis comparing three models of care. Cerebrovasc Dis. 2007;23(2-3):194- 202. doi:10.1159/000097641

Acil Serviste İskemik İnme Hastalarının Yönetimine İnme Ünitesinin Etkisi: 5 Yıllık Geriye Dönük Tarama

Yıl 2025, Cilt: 8 Sayı: 1, 13 - 18, 29.03.2025
https://doi.org/10.54996/anatolianjem.1564648

Öz

Amaç: İskemik inme dünya genelinde önemli bir morbidite ve mortalite nedenidir. Tedavi sürecinin inme ünitesi olarak adlandırılan özelleşmiş bakım merkezlerinde yapılması önerilmektedir. Bu çalışmanın amacı, inme ünitesinin (İÜ) acil servisteki inme hastalarının tedavisine etkisini araştırmaktır.

Gereç ve Yöntemler: Bu retrospektif gözlemsel çalışma Dokuz Eylül Üniversitesi Tıp Fakültesi Hastanesi Acil Servisinde yapıldı. İskemik inme tanısı alan 18 yaş üstü hastalar çalışmaya dahil edildi. İnme ünitesi öncesi ve sonrası dönemde hastaların demografik özellikleri, verilen tedaviler, acil serviste ve hastanede kalış zamanı karşılaştırıldı.

Bulgular: Bu çalışmaya 1546 hasta dahil edildi. Hastaların 583’ü İÜ öncesi, 963 tanesi İÜ sonrası dönemde hastaneye kabul edildi. İnme geçiren hastaların çoğunluğu (%56) erkekti. İÜ açılmadan önceki hastaların yaş ortalaması 72±12,4 yaş; İÜ açıldıktan sonraki yaş ortalaması 70±12,9 yaş bulundu. En çok başvurunun 71-80 yaş grubunda olduğu görüldü. Hastaların hastaneye başvuru nedenleri arasında en sık kol ve bacakta güç kaybı ve konuşma bozukluğu yer almaktadır. İÜ öncesi iskemik inme hastalarının %1,2’sine, İÜ sonrası ise %5,5’ine trombolitik tedavi verilmişti. (p=0,00). İÜ öncesi ve sonrası dönemde hastanede kalış süreleri sırasıyla 10,7 ±8,3 gün ve 9,4±8,3 gün bulunmuştur. Mortalite İÜ öncesi dönemde %8,6 iken İÜ sonrası dönemde %6,7 bulundu.

Sonuç: İÜ açılmasıyla trombolitik tedavi verilme oranında artış olmuştur. İÜ'nin mortaliteye üzerine etkisi olmamıştır. Hasta sayısının artmasına rağmen hastaların acil serviste kalış süresinde değişiklik olmamış fakat hastanede kalış süresi kısalmıştır.

Etik Beyan

Ethical approval was obtained from the Dokuz Eylul University Hospital Clinical Research Ethics Committee before the study (Decision No. 2011/01-08).

Destekleyen Kurum

Destekleyen kurum yoktur.

Kaynakça

  • Feigin VL, Brainin M, Norrving B, et al. World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. International Journal of Stroke. 2022;17(1):18-29. doi:10.1177/17474930211065917
  • World Health Organization. Health statistics of Türkiye. 2019. Available at: https://data.who.int/countries/792. Accessed 08 September 2024.
  • Türkiye Istatistik Kurumu. Health statistics of 2019. Available at: https://data.tuik.gov.tr/Kategori/GetKategori?p=nufus-ve-demografi109&dil=1. Accessed 10 September 2024.
  • World Health Organization. Cerebrovascular Disorders: A Clinical and Research Classification.1978. WHO offset Publication no:43.
  • Kleindorfer DO, Towfighi A, Chaturvedi S, et al. 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2021;52(7). doi:10.1161/STR.0000000000000375
  • Langhorne P. The Stroke Unit Story: Where Have We Been and Where Are We Going? Cerebrovasc Dis. 2021;50(6):636-643. doi:10.1159/000518934
  • Garraway WM, Akhtar AJ, Prescott RJ, Hockey L. Management of acute stroke in the elderly: preliminary results of a controlled trial. Br Med J. 1980;280(6220):1040-1043. doi:10.1136/bmj.280.6220.1040
  • Indredavik B, Bakke F, Solberg R, Rokseth R, Haaheim LL, Holme I. Benefit of a stroke unit: a randomized controlled trial. Stroke. 1991;22(8):1026-1031. doi:10.1161/01.str.22.8.1026
  • Rønning OM, Guldvog B. Stroke units versus general medical wards, I: twelve- and eighteen-month survival: a randomized, controlled trial. Stroke. 1998;29(1):58-62. doi:10.1161/01.str.29.1.58
  • Langhorne P, Ramachandra S, Stroke Unit Trialists’ Collaboration. Organised inpatient (stroke unit) care for stroke: network metaanalysis. Cochrane Database Syst Rev. 2020;4(4):CD000197. doi:10.1002/14651858.CD000197.pub4
  • Sun Y, Paulus D, Eyssen M, Maervoet J, Saka O. A systematic review and meta-analysis of acute stroke unit care: what’s beyond the statistical significance? BMC Med Res Methodol. 2013;13:132. doi:10.1186/1471-2288-13-132
  • Kumral E, Ozkaya B, Sagduyu A, Sirin H, Vardarli E, Pehlivan M. The Ege Stroke Registry: a hospital-based study in the Aegean region, Izmir, Turkey. Analysis of 2,000 stroke patients. Cerebrovasc Dis. 1998;8(5):278-288. doi:10.1159/000015866
  • Bornstein NM, Aronovich BD, Karepov VG, et al. The Tel Aviv Stroke Registry. 3600 consecutive patients. Stroke. 1996;27(10):1770-1773. doi:10.1161/01.str.27.10.1770
  • Bousser MG, Amarenco P, Chamorro A, et al. The Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic attack (PERFORM) study: baseline characteristics of the population. Cerebrovasc Dis. 2009;27(6):608-613. doi:10.1159/000216835
  • Centers for Disease Control and Prevention (CDC). Annual smokingattributable mortality, years of potential life lost, and productivity losses--United States, 1997-2001. MMWR Morb Mortal Wkly Rep. 2005;54(25):625-628.
  • Rey V, Faouzi M, Huchmand-Zadeh M, Michel P. Stroke initial severity and outcome relative to insurance status in a universal health care system in Switzerland. Eur J Neurol. 2011;18(8):1094-1097. doi:10.1111/j.1468-1331.2010.03264.x
  • Bai X, Li Z, Cai Z, Yao M, Chen L, Wang Y. Gender differences in risk factors for ischemic stroke: a longitudinal cohort study in East China. BMC Neurol. 2024;24(1):171. doi:10.1186/s12883-024-03678-0
  • Kim HJ, Ahn JH, Kim SH, Hong ES. Factors associated with prehospital delay for acute stroke in Ulsan, Korea. J Emerg Med. 2011;41(1):59-63. doi:10.1016/j.jemermed.2010.04.001
  • Yanagida T, Fujimoto S, Inoue T, Suzuki S. Prehospital delay and strokerelated symptoms. Intern Med. 2015;54(2):171-177. doi:10.2169/internalmedicine.54.2684
  • Revathi S, Kavitha MS, Shankar V. Factors Associated with Prehospital Delay in Patients with Acute Stroke in South India. Indian J Community Med. 2023;48(1):82-90. doi:10.4103/ijcm.ijcm_213_22
  • Keskin O, Kalemoğlu M, Ulusoy RE. A clinic investigation into prehospital and emergency department delays in acute stroke care. Med Princ Pract. 2005;14(6):408-412. doi:10.1159/000088114
  • Korkmaz T, Ersoy G, Kutluk K, et al. An Evaluation of Pre-Admission Factors Affecting the Admission Time of Patients with Stroke Symptoms. . Turk J Emerg Med . 2010;10:106-111.
  • Barber PA, Zhang J, Demchuk AM, Hill MD, Buchan AM. Why are stroke patients excluded from TPA therapy? An analysis of patient eligibility. Neurology. 2001;56(8):1015-1020. doi:10.1212/wnl.56.8.1015
  • Lattimore SU, Chalela J, Davis L, et al. Impact of establishing a primary stroke center at a community hospital on the use of thrombolytic therapy: the NINDS Suburban Hospital Stroke Center experience. Stroke. 2003;34(6):e55-7. doi:10.1161/01.STR.0000073789.12120.F3
  • Gillum LA, Johnston SC. Characteristics of academic medical centers and ischemic stroke outcomes. Stroke. 2001;32(9):2137-2142. doi:10.1161/hs0901.094260
  • Rocha MSG, Almeida ACF, Abath Neto O, Porto MPR, Brucki SMD. Impact of stroke unit in a public hospital on length of hospitalization and rate of early mortality of ischemic stroke patients. Arq Neuropsiquiatr. 2013;71(10):774-779. doi:10.1590/0004- 282X20130120
  • Chan DKY, Cordato D, O’Rourke F, et al. Comprehensive stroke units: a review of comparative evidence and experience. Int J Stroke. 2013;8(4):260-264. doi:10.1111/j.1747-4949.2012.00850.x
  • Foley N, Salter K, Teasell R. Specialized stroke services: a meta-analysis comparing three models of care. Cerebrovasc Dis. 2007;23(2-3):194- 202. doi:10.1159/000097641
Toplam 28 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Acil Tıp
Bölüm Orijinal Çalışma
Yazarlar

Cem Şimşek 0000-0003-1326-047X

Sedat Yanturalı 0000-0002-6011-3424

Dijan Tav Şimşek 0000-0001-8675-2382

Rıdvan Atilla 0000-0002-2260-6981

Erken Görünüm Tarihi 29 Mart 2025
Yayımlanma Tarihi 29 Mart 2025
Gönderilme Tarihi 10 Ekim 2024
Kabul Tarihi 16 Aralık 2024
Yayımlandığı Sayı Yıl 2025 Cilt: 8 Sayı: 1

Kaynak Göster

AMA Şimşek C, Yanturalı S, Tav Şimşek D, Atilla R. The Effect of Stroke Units on The Management of Ischemic Stroke Patients in the Emergency Department: A Retrospective 5-Year Study. Anatolian J Emerg Med. Mart 2025;8(1):13-18. doi:10.54996/anatolianjem.1564648