Laktoperoksidaz enzimini inhibe eden maddelerin belirlenmesi için yapılan bazı çalışmaların incelenmesi ve enzimin uygulama alanlarının örneklendirilmesi

Yıl 2019, Cilt 2, Sayı 2, 1 - 8, 31.12.2019

Gözde BAYDEMİR PEŞİNT Ece KAYA Hatice İmge OKTAY BAŞEĞMEZ

Öz

Lactoperoxidase (LPO; E.C. 1.11.1.7) was isolated from milk in 1940s by Theorell et al., and in the following years, it was purified by Morrison et al. using ion-exchange chromatography. This enzyme is a glycoprotein that is a member of the peroxidase family and contains the heme group as a prosthetic group. Lactoperoxidase is an oxidoreductase enzyme that exhibits antimicrobial action against pathogens secreted from the digestive tract of newborns. This enzyme is found in saliva and tears as well as in milk.

The determination of lactoperoxidase inhibitors and how the enzyme will be affected in case of antibiotic use is very important for newborn health. The studies reviewed here contain references for the determination of the inhibitors of lactoperoxidase and the degree of inhibition of these inhibitors, and the use of antibiotics in newborns. At the same time, it is very important to know the substances that increase the activity of the enzyme, especially for use in the food and pharmaceutical industries.

Anahtar Kelimeler

Enzim, Laktoperoksidaz, Saflaştırma

Kaynakça

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