ORAL SURGICAL PROCEDURES IN PATIENTS WITH OSTEOPOROSIS

Öz

Osteoporosis is a progressive systemic bone disease that is characterized by an increase in fragility, decreased bone volume and risk of fracture. It affects the cancellous part of the bone as well as its cortical part. The most important complication of osteoporosis on oral and maxillofacial components is the decrease in bone mass and density and periodontitis. There is no definitive contraindication associated with maxillofacial surgical procedures in this group of patients; almost all of the related surgical procedures could be applied if the suitable circumstances will be ensured. This review is focused on the particular points of the oral and maxillofacial surgical procedures including dental implant procedures in patients with osteoporosis

Anahtar Kelimeler

• Osteoporosis, oral surgical procedures, dental implant

OSTEOPOROZ HASTALARINDA ORAL CERRAHİ UYGULAMALAR

Öz

Osteoporoz, ilerleyici karakterde bir sistemik kemik hastalığı olup, artmış frajilite, düşük kemik kütlesi ve kırık riski ile karakterizedir. Osteoporoz, hem kortikal hem de kansellöz kemiğin yapısını etkilemektedir. Osteoporozun oral ve maksillofasiyal yapılar üzerine olan en önemli etkileri; kemik hacmi ve dansisitesinde azalma ile periodontitistir. Bu hasta grubunda oral ve maksillofasiyal cerrahi işlemler için kesin kontraendikasyon bulunmamakla beraber, uygun durum ve koşulların sağlanarak pre- ve postoperatif dönemde komplikasyondan uzak sonuçlar elde edilebilir. Bu derlemede,  osteoporozlu hastalarda dental implant uygulamaları da dahil olmak üzere oral ve maksillofasiyal cerrahi işlemlerde dikkat edilmesi gereken hususlar derlenmiştir.

Anahtar Kelimeler

• Osteoporoz, oral cerrahi uygulamalar, dental implant

Kaynakça

1. Şahin M, Demirağ NG. Osteoporoz. Türk Ortopedi ve Travmatoloji Birliği Derneği Dergisi 2004;3:1-2.
2. National Osteoporosis Foundation. Osteoporosis: review of the evidence for prevention, diagnosis, and treatment and cost-effectiveness analysis, Osteoporos Int 1998;8:1-88.
3. Christiansen C: Skeletal osteoporosis. J Bone Miner Res 1993;8 Suppl 2:475-80.
4. White SC. Oral radiographic predictors of osteoporosis. Dentomaxillofac Radiol 2002;31:84- 92.
5. López-López J, Estrugo-Devesa A, Jane-Salas E, Ayuso-Montero R, Gómez-Vaquero C. Early diagnosis of osteoporosis by means of orthopantomograms and oral x-rays. a systematic review. Med Oral Patol Oral Cir Bucal 2011;16:905- 13.
6. Díaz-Correa LM, Ramírez-García LM, Castro- Santana LE, Vilá LM. Osteoporosis knowledge in patients with a first fragility fracture in Puerto Rico. Bol Asoc Med 2014;106:6-10.
7. Dunn, J.C. Risedronate: a review of its pharmacological properties and clinical use in resobtive bone disease. Drugs 2001;61:685-712.
8. Ettinger, B. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. JAMA 1999;282:637-45.

9. Khan A, Fortier M; Menopause and Osteoporosis Working Group, Fortier M, Reid R, Abramson BL, Blake J, Desindes S, Dodin S, Graves L, Guthrie B, Johnston S, Khan A, Rowe T, Sodhi N, Wilks P, Wolfman W. Osteoporosis in menopause. J Obstet Gynaecol Can 2014;36:839-40.
10. Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women’s Health Initiative randomized controlled trial. JAMA 2002;288: 321-33.
11. Inagaki K, Kurosu Y, Kamiya T, Kondo F, Yoshinari N, Noguchi T, Krall EA, Garcia RI. Low metacarpal bone density, tooth loss, and periodontal disease in Japanese women. J Dent Res 2001;80:1818-22.
12. Mogi M, Otogoto J, Ota N, Inagaki H, Minami M, Kojima K. Interleukin 1 beta, interleukin 6, beta 2- microglobulin, and transforming growth factor- alpha in gingival crevicular fluid from human periodontal disease. Arch Oral Biol 1999;44:535-9.
13. Mohammad AR, Hooper DA, Vermilyea SG, Mariotti A, Preshaw PM. An investigation of the relationship between systemic bone density and clinical periodontal status in post-menopausal Asian- American women. Int Dent J 2003;53:121-5.
14. Yoshihara A, Seida Y, Hanada N, Miyazaki H. A longitudinal study of the relationship between periodontal disease and bone mineral density in community-dwelling older adults. J Clin Periodontol 2004;31:680-4.
15. Bando K, Nitta H, Matsubara M, Ishikawa I. Bone mineral density in periodontally healthy and edentulous Periodontol 1998;3:322-6. women. Ann
16. Famili P, Cauley J, uzuki JB, Weyant R. Longitudinal study of periodontal disease and edentulism with rates of bone loss in older women. J Periodontol 2005;76:11-5.
17. Friedlander AH. The physiology, medical management and oral implications of menopause. J Am Dent Assoc 2002;133:73-81.
18. Geurs NC, Lewis CE, Jeffcoat MK. Osteoporosis and periodontal disease progression. Periodontol 2000 2003;32:105-10.
19. Krejci CB BNF. Women's health issues and their relationship to periodontitis.J Am Dent Assoc 2001;133:323-9.
20. Lundstrom A, Jendle J, Stenstrom B, Toss G, Ravald N. Periodontal conditions in 70-year-old women with osteoporosis. Swed Dent J 2001;25:89-96.
21. Persson RE, Hollender LG, MacEntee MI, Wyatt CC, Kiyak HA, Persson GR. Assessment of periodontal conditions and systemic disease in older subjects. J Clin Periodontol 2003;30:207-13.
22. Civitelli R, Pilgram TK, Dotson M, Muckerman J, Lewandowski N, Armamento-Villarea R,Yokoyama- Crothers N, Kardaris EE, Hauser J, Cohen S, Hildebolt CF. Alveolar and postcranial bone density in hormone/estrogen randomized, double-blind, placebo-controlled trial. Arch Intern Med 2002;162:1409-15. receiving replacement therapy: a
23. Geurs NC, Lewis CE, Jeffcoat MK. Osteoporosis and periodontal disease progression . Periodontol 2000 2003;32:105-10.
24. Grossi SG. Effect of estrogen supplementation on periodontal disease. Compend Contin Educ Dent Suppl 1998;22:30-6.
25. Inagaki K, Kurosu Y, Kamiya T, Kondo F, Yoshinari N, Noguchi T, Krall EA, Garcia RI. Low metacarpal bone density, tooth loss, and periodontal disease in Japanese women. J Dent Res 2001;80:1818-22.
26. Inagaki K, Kurosu Y, Yoshinari N, Noguchi T, Krall EA, Garcia RI. Efficacy of Periodontal Disease and Tooth Loss to Screen for Low Bone Mineral Density in Japanese Women. Calcif Tissue Int 2005;77:9- 14.
27. Keklikoğlu N, Duman S. Yaşlanma ve menopozun kemik ve dişlere etkileri. İstanbul Üniv Diş Hek Fak Derg 2004;38:25-35.
28. Reinhardt RA, Payne JB, Maze C, Babbitt M, Nummikoski PV, Dunning D. Gingival fluid IL-1beta in postmenopausal females on supportive periodontal therapy. A longitudinal 2-year study. J Clin Periodontol 1998;25:1029-35.
29. Tezal M, Wactawski-Wende J, Grossi SG, Ho AW, Dunford R, Genco RJ. The relationship between bone mineral density and periodontitis in postmenopausal 2000;71:1492-8. J Periodontol
30. Wactawski-Wende J. Periodontal diseases and osteoporosis: association and mechanisms. Ann Periodontol 2001;6:197-208.
31. Guglielmi G, di Chio F, Vergini MR, La Porta M, Nasuto M, Di Primio LA. Early diagnosis of vertebral fractures. Clin Cases Miner Bone Metab 2013;10:15-8.
32. Werning JW, Downey NM, Brinker RA, Khuder SA, Davis WJ, Rubin AM, Elsamaloty HM. The impact of osteoporosis on patients with maxillofacial trauma. Arch Otolaryngol Head Neck Surg 2004;130:353-6.
33. von Wovern N. Dual-photon absorptiometry of mandibles: in vitro test of a new method. Scand J Dent Res 1985;93:169-77.
34. Bollen AM, Taguchi A, Hujoel PP, Hollender LG. Case-control study on self-reported osteoporotic fractures and mandibular cortical bone. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000;90:518-24.
35. Otto S, Pautke C, Hafner S, Hesse R, Reichardt LF, Mast G, Ehrenfeld M, Cornelius CP. Pathologic fractures in bisphosphonate-related osteonecrosis of the jaw-review of the literature and review of our own cases. Craniomaxillofac Trauma Reconstr 2013;6:147-54.
36. Blomqvist JE, Alberius P, Isaksson S, Linde A, Hansson BG. Factors in implant integration failure after bone grafting: an osteometric and endocrinologic matched analysis. Int J Oral Maxillofac Surg 1996;25:63-8. 37. Garg AK, Winkler S, Bakaeen LG, Mekayarajjananonth T. Dental implants and the geriatric patient. Implant Dent 1997;6:168-73.
37. Baxter JC, Fattore L. Osteoporosis and osseointegration of implants. J Prosthodont 1993;2:120-5.
38. Bochlogyros PN. Non-union of fractures of the mandible. J Maxillofac Surg 1985;13:189-93.
39. Bruce RA, Ellis E. 3rd. The second Chalmers J. Lyons Academy study of fractures of the edentulous mandible. J Oral Maxillofac Surg 1993;51:904-11.
40. Kunz C, Hammer B, Prein J. Fractures of the edentulous management and complications. Mund Kiefer Gesichtschir 2001;5:227-32. Fracture
41. Mellado-Valero A, Ferrer-García JC, Calvo-Catalá J, Labaig-Rueda C. Implant treatment in patients with osteoporosis. Med Oral Patol Oral Cir Bucal 2010;15:52-7.
42. Fugazzotto PA, Lightfoot WS, Jaffin R, Kumar A. Implant placement with or without simultaneous tooth extraction in patients taking oral bisphosphonates: postoperative healing, early follow-up, and the incidence of complications in two private practices. J Periodontol 2007;78:1664- 9.
43. Bagán J, Blade J, Cozar JM, Constela M, García Sanz R, Gómez Veiga F, Lahuerta JJ, Lluch A, Massuti B, Morote J, San Miguel JF, Solsona E. Recommendations for the prevention, diagnosis, and treatment of osteonecrosis of the jaw (ONJ) in cancer patients treated with bisphosphonates. Med Oral Patol Oral Cir Bucal 2007;12: 336-40.
44. Schou S, Holmstrup P, Worthington HV, Esposito M. Outcome of implant therapy in patients with previous tooth loss due to periodontitis. Clin Oral Implants Res 2006;17:104-23.
45. Tsolaki IN, Madianos PN, Vrotsos JA. Outcomes of dental implants in osteoporotic patients. A literature review. J Prosthodont 2009;18:309-23.
46. Grant BT, Amenedo C, Freeman K, Kraut RA. Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases. J Oral Maxillofac Surg. 2008;66:223-30.
47. Fini M, Giavaresi G, Torricelli P, Borsari V, Giardino R, Nicolini A, Carpi A. Osteoporosis and biomaterial osteointegration. 2004;58:487-93. Pharmacother
48. Junker R, Dimakis A, Thoneick M, Jansen JA. Effects of implant surface coatings and composition on bone integration: a systematic review. Clin Oral Implants Res 2009;4:185-206.
49. de Jonge LT, Leeuwenburgh SC, Wolke JG, Jansen JA. Organic-inorganic surface modifications for titanium 2008;25:2357-69. Pharm Res
50. Schouten C, Meijer GJ, van den Beucken JJ, Leeuwenburgh SC, de Jonge LT, Wolke JG, Spauwen PH, Jansen JA. In vivo bone response and mechanical evaluation of electrosprayed CaP nanoparticle coatings using the iliac crest of goats as an implantation model. Acta Biomater 2010;6:2227-36.
51. Leeuwenburgh SC, Wolke JG, Siebers MC, Schoonman J, Jansen JA. In vitro and in vivo reactivity of porous, electrosprayed calcium phosphate coatings. Biomaterials 2006;27:3368- 78.
52. Aspenberg P. Bisphosphonates and implants: an overview. Acta Orthop 2009;80:119-23.
53. Marie PJ. Strontium as therapy for osteoporosis. Curr Opin Pharmacol. 2005;5:633-6.
54. Selvi F, Çakarer S, Can T, Kırlı İ, Palancıoğlu A, Yaltırık M, Keskin C. Bifosfonat kullanmış veya kullanmakta olan hastalarda dental implant uygulamaları: Literatür derlemesi Atatürk Üniv. Diş Hek. Fak. Derg 2011;21:266-73.