DENTAL STEM CELLS AND THE IMPORTANCE OF DECIDIOUS TEETH FOR STEM CELL STUDIES

Yıl 2014, Cilt: 24 Sayı: Supplement 8, 98 - 106, 11.02.2015

Gülcan Ünsal Özge Özmekik İşın Ulukapı

https://doi.org/10.17567/dfd.45489

Öz

Stem cells are fundemental cells that have charecteristics of self-renewal and being divided unlimitedly, and generate tissue and organs. Dental stem cells have taken place among the postnatal stem cell sources as they are easy to get and require minimally invasive process. Multipotent stem cells in dental pulp, apical papilla, periodontal ligament, dental follicle and decidious teeth are isolated. It is determined that stem cells from human exfoliated decidious teeth differantiate to neurons, adipocytes, chondrocytes, osteoblasts and odontoblasts, and it is reported that they can be alternative stem cell source at autolog stem cell based therapy

Anahtar Kelimeler

Stem cell, decidious teeth, mesenchyme, multipotent

DENTAL KÖK HÜCRELER VE SÜT DİŞLERİNİN KÖK HÜCRE ÇALIŞMALARINDAKİ ÖNEMİ

Öz

Kök hücreler sınırsız bölünebilme ve kendini yenileme özelliğine sahip, vücudumuzda doku ve organları oluşturan ana hücrelerdir. Kolay ulaşılabilmeleri ve minimal invaziv işlem gerektirmeleri nedeni ile dental kök hücreler postnatal kök hücre kaynakları arasında yerini almıştır. Dental pulpada, apikal papillada, periodontal ligamentte, dental folikülde ve süt dişinde multipotent kök hücreler izole edilmiştir. Düşen süt dişi kök hücrelerinin nöronlara, adipozitlere, kondrositlere, osteoblastlara ve odontoblastlara diferansiye olduğu tespit edilmiş, otolog kök hücre tabanlı tedavilerde alternatif kök hücre kaynağı oluşturabileceği bildirilmiştir.

Anahtar Kelimeler

Kök Hücre, süt dişi, mezenkim, multipotent

Kaynakça

• Verfaillie CM, Pera MF, Lansdorp PM. Stem Cells:Hype and Reality. Am Soc Hem Educ Program. 2002;369-91
• Sağsöz H, Ketani MA. Stem Cells. J Fac Vet Med Univ Dicle 2008;129–33
• Suchanek J, Visek B, Soukup T, Sked M, Ivancakova R, Mokry J, Aboul-Ezz EHA, Omran A. Stem Cells from Human Exfoliated Deciduous Teeth – Isolation, Long Term Cultivation and Phenotypical Kralove) 2010;53:93–9 Acta Medica(Hradec
• Şahin F, Saydam G, Omay SB. Stem Cell Plasticity and Stem Cell Treatment in Clinical Practice. Turk J Hematol Oncol 2005;1-15
• Silver LM. The Proteus Effect: Stem Cells and Their Promise for Medicine. Reviewed by Parson AB. Stalking Life's Second Secret. Autumn Books Nature 2004;431:905-7.
• Güneş AM. Stem Cell Plasticity and Uses in Medicine. J Pediatr Date 2005;71/36-42
• Kansu E. Current Concepts in Stem Cell Biology and Plasticity. Hacettepe Med J 2005;36:191-197
• Karaşahin T. Embryonic Stem Cells. J Fac Vet Med Univ Erciyes 2012; 9: 65-71
• Lozano FJR, Insausti CL, Iniesta F, Blanquer M, Ramírez MC, Meseguer L, Meseguer-Henarejos AB, Marín N, Martínez S, Moraleda MJ. Mesenchymal Dental Stem Cells in Regenerative Dentistry. Med Oral Patol Oral Cir Bucal 2012;17 :1062-7
• Snykers S, Kock JD, Rogiers V, Vanhaecke T. In Vitro Differentiation of Embryonic and Adult Stem Cells Into Hepotocytes:State of the Art. Stem Cells 2009;27:577-605
• Mudda JA, Bajaj M. Stem Cell Therapy:A Challenge to Periodontist . IJDR 2011;22/1 132-9
• Kara MA. About Stem Cell Research. Klin J Med Ethics Law History 2004; 12:121-31
• Telles PD, Machado MAAM, Sakai VT, Eduardo J. Pulp Tissue from Primary Teeth: New Source of Stem Cells. J Appl Oral Sci. 2011;19:189-94
• Ulmer FL, Winkel A, Kohorst P, Stiesch M. Stem Cells –Prospects in Dentistry. Schweiz Monatsschr Zahnmed 2010;120 10
• O'Donoghue K, Fisk NM . Fetal Stem Cells:Best Practice and Research. Clin Obstet Gynecol 2004;18:853-75
• Campagnoli C, Roberts IA, Kumar S. Identification of Mesenchymal Stem/Progenitor Cells in Human First-Trimester Fetal Blood, Liver, and Bone Marrow. Blood 2001; 98: 2396–402.
• You-Young JO, Lee HJ, Kook SY, Choung HW, Park JY, Chung JH, Choung YH, Kim ES, Yang HC, Choung PH. Isolation and Characterization of Postnatal Stem Cells from Human Dental Tissues. Tissue Eng 2007;13: 4
• Brar GS, Toor RSS. Dental stem cells: Osteogenic Dentinogenic, Differentiation and Its Clinical Cell Based Therapies. Indian J Dental 2012;23: 3 Neurogenic
• Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S. SHED:Stem Cells from Human Exfoliated Deciduous Teeth. Proc Natl Acad Sci 2003;100: 5807-12
• Sharpe PT. Neural Crest and Tooth Morphogenesis. Adv Dent Res 2001;1:4-7
• Bluteau G, Luder HU, Bari CD. Stem Cells for Tooth Engineering. Eur Cells Mater 2008;16: 1
• Nourbakhsh N, Soleimani M, Taghipour Z, Karbalaie K, Mousavi S, Talebi A. Induced in Vitro Differentiation of Neural-Like Cells from Human Exfoliated Deciduous Teeth-Derived Stem Cells. Int J Dev Biol 2011;55: 189-95
• Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J. Investigation of Multipotent Postnatal Stem Cells from Human Periodontal Ligament. Lancet 2004;10-16;364:149-55
• Mori G, Ballini A, Carbone C, Oranger A, Brunetti G, Benedetto AD. Osteogenic Differentiation of Dental Follicle Stem Cells. Int. J. Med. Sci 2012;9:480-7
• Morsczeck C, Vollner F, Saugspier M, Brandl C, Reichert T.E, Driemel O. Comparison of Human Dental Follicle Cells and Stem Cells from Human Exfoliated Differentiation in Vitro. Clin Oral Investig 2010;14: 433-40. Teeth After Neural
• Yao S, Pan F, Prpic V, Wise GE. Differentiation of Stem Cells in the Dental Follicule. J Dent Res 2008; 87: 767-71.
• Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S. Characterization of the Apical Papilla and Its Residing Stem Cells from Human Immature Permanent Teeth: a Pilot Study. J Endod 2008; 2/34: 166-71.
• Huang AHC, Chen YK, Lin LM, Shieh TY, Chan AWS. Isolation and Characterization of Dental Pulp Stem Cells from a Supernumerary Tooth. J Oral Pathol Med 2008;37: 571–4
• Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal Human Dental Pulp Stem Cells in Vitro and in Vivo. PNAS 2000;5: 25
• Süzergöz F, Erdem AP, Sepet E, Bektaş M, Yalman N, Gürol AO. A Pilot Study on the Isolation of Dental Pulp Stem Cells, Potential of Forming Colonies and Defining the Content of Stem Cells. Turkiye Klinikleri J Med Sci 2009;29:128-33
• Kerkis I, Caplan AI. Stem Cells in Dental Pulp of Deciduous Teeth. Tissue Eng Part B 2012/18:2
• Seo BM, Sonayama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K. SHED Repair Critical-Size Calvarial Defects in Mice. Oral Dis 2008;14:428-434
• Zheng Y, Liu Y, Zhang CM, Zhang HY, Li WH. Stem Cells from Deciduous Tooth Repair Mandibular Defect in Swine. J Dent Res 2009;88:249
• Aydın A, Berbercan P. Biyomühendislik Esasları ile Diş Oluşturulmasına Yönelik Yaklaşımlar. SÜ Dişhek Fak Derg 2010;19:99-114
• Cordeiro MM, Dong Z, Kaneko T, Zhang Z, Miyazawa M, Shi S. Dental Pulp Tissue Engineering with Stem Cells from Exfoliated Deciduous Teeth. JOE 2008;34: 8
• Yamaza T, Kentaro A, Chen C, Liu Y, Gronthos S, Wang S. Immunmodulatory Properties of Stem Cells from Human Exfoliated Deciduosus Teeth. Stem Cell Research Therapy 2010;1: 5
• Wang X, Sha XJ, Li GH, Yang FS, Ji K, Wena LY. A Comparative Characterization of Stem Cells from Human Exfoliated Deciduous Teeth and Dental Pulp Stem Cells. Archives of Oral Biology 2012; 57:1231–40
• Govindasamy V, Abdullah AN, Ronald VS, Musa S, Aziz ZACA, Zain RB. Inherent Differential Propensity of Dental Pulp Stem Cells Derived from Human Deciduous and Permanent Teeth. JOE 2010;36: 9
• Wang J, Wang X, Sun Z, Wang X, Yang H, Shi S. Stem Cells from Human Exfoliated Deciduous Teeth Can Differentiate into Dopaminergic Neuron- like Cells. Stem Cells Deve 2010;19:1375-83.
• Ishkitiev N, Yaegaki K, Calenic B. Deciduous and Permanent Dental Pulp Mesenchymal Cells Acquire Hepatic Morphologic and Functional Features in Vitro. J Endod 2010;36:469–74
• Arora V, Arora P, Munshi AK. Banking Stem Cells from Human Exfoliated Deciduous Teeth: Saving for the Future. Journ Clinic Pediat Dent 2009;33: 4
• Perry BC, Zhou D, Wu X, Yang FC, Byers MA, Chu TM. Characterization of Human Dental Pulp-Derived Mesenchymal Stem Cells for Banking and Clinical use. Tissue Eng Part C Methods 2008;4: 149–56.