Yıl 2020, Cilt 30 , Sayı 4, Sayfalar 536 - 544 2020-10-15

EVALUATION OF THE EFFECT OF CHRONIC PERIODONTITIS AND ADDITIONAL TOBACCO ABUSE ON OXIDATIVE STATUS : A CROSS-SECTIONAL STUDY
EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY

Didem ÖZKAL EMİNOĞLU [1] , Varol ÇANAKÇI [2]


Aim: The aim of the present study was to investigate the 8-hydroxy-2´deoxyguanosine (8-OHdG) and melatonin (MLT) levels in saliva as well as myeloperoxidase (MPO) levels in gingival clevicular fluid (GCF) in smoker and nonsmoker chronic periodontitis (CP) patients and periodontally healthy individuals. Methods: 4 groups of 15 applicants were formed in accordance with the research protocole as follows; periodontally healthy nonsmokers (CP-S-), periodontally healthy smokers (CP-S+), nonsmoker periodontitis patients (CP+S-) and smoker periodontitis patients (CP+S+). Clinical periodontal parameters were recorded before taking the GCF and saliva samples. 8-OHdG, MLT and MPO levels were measured biochemically. Results: The lowest 8-OHdG and MPO levels were recorded in the (CP-S-) group (p<0.05). 8-OHdG and MPO levels were statistically higher in (CP-S+) group than (CP-S-) group (p<0.05). MLT levels in saliva were statistically higher in periodontally healthy (CP-) groups than CP groups (p<0.05). Conclusions: CP causes a significant difference on the parameters connected with oxidative stress. For periodontally healthy applicants, smoking leads to statistically significant changes on the parameters in general; while the effect of smoking to the parameters was found insignificant in the CP groups. Findings of this study reveal the role of smoking on the development of periodontitis, due to negatively affecting the parameters linked to oxidative stress, that are crucial in the patogenesis of periodontal diseases. KEY WORDS: 8-hydroxy-2´-deoxyguanosine (8-OHdG), chronic periodontitis (CP), melatonin (MLT), myeloperoxidase (MPO), oxidative stres (OS), smoking, tobacco. Kronik Periodontitis Ve Sigara Kullananımının Oksidatif Durum Üzerine Olan Etkisinin Değerlendirilmesi Öz Amaç: Bu çalışmanın amacı; kronik periodontitisli ve periodontal açıdan sağlıklı bireylerin DOS ve tükürük numunelerinde sigaranın MLT, MPO ve 8-OHdG düzeyleri üzerine muhtemel etkilerinin değerlendirilmesidir. Gereç ve yöntem : Çalışma protokolü gereği her biri 15 katılımcıdan oluşan 4 grup oluşturuldu; periodontal olarak sağlıklı ve sigara içemeyen grup (P-S-), periodontal olarak sağlıklı ve sigara içen grup (P-S+), kronik periodontitisli ve sigara içmeyen grup (P+S-) ile kronik periodontitisli ve sigara içen grup (P+S+). DOS ve tükürük örnekleri alınmadan önce klinik periodontal parametreler kaydedildi. MLT, MPO ve 8-OHdG düzeyleri biyokimyasal ve olarak ölçüldü. Bulgular : En yüksek MPO ve 8-OHdGdüzeyleri ile en düşük MLT düzeyleri (P+S+) grubunda tespit edildi. En yüksek MLT düzeyi ise (P-S-) grubunda gözlendi. Sigara kullanımı ve kronik periodontitisin biyokimyasal ve histopatolojik parametreleri benzer şekilde etkilediği tespit edildi. Sonuç : KP’nin oksidatif stres ile ilişkili parametrelerde anlamlı düzeyde farklılık oluşturduğu gözlendi. Sigara kullanımının genel olarak periodontal sağlıklı bireylerde parametrelerde belirgin bir değişime yol açtığı, periodontitisli gruplarda ise bu değişimin istatistiksel olarak anlamlı olmadığı görüldü. Bulgularımız, sigara içmenin periodontal hastalıkların patogenezinde rol alan oksitatif parametreleri olumsuz yönde etkileyerek periodontitis gelişiminde rol oynayabileceğini göstermektedir. Anahtar Kelimeler: Isı şok proteinleri 60-70, kronik periodontitis, melatonin, myeloperoksidaz, oksitatif stress, sigara, 8-hydroxy-2'-deoxyguanosine.
Aim: The aim of the present study was to investigate the 8-hydroxy-2´deoxyguanosine (8-OHdG) and melatonin (MLT) levels in saliva as well as myeloperoxidase (MPO) levels in gingival clevicular fluid (GCF) in smoker and nonsmoker chronic periodontitis (CP) patients and periodontally healthy individuals. Methods: 4 groups of 15 applicants were formed in accordance with the research protocole as follows; periodontally healthy nonsmokers (CP-S-), periodontally healthy smokers (CP-S+), nonsmoker periodontitis patients (CP+S-) and smoker periodontitis patients (CP+S+). Clinical periodontal parameters were recorded before taking the GCF and saliva samples. 8-OHdG, MLT and MPO levels were measured biochemically. Results: The lowest 8-OHdG and MPO levels were recorded in the (CP-S-) group (p<0.05). 8-OHdG and MPO levels were statistically higher in (CP-S+) group than (CP-S-) group (p<0.05). MLT levels in saliva were statistically higher in periodontally healthy (CP-) groups than CP groups (p<0.05). Conclusions: CP causes a significant difference on the parameters connected with oxidative stress. For periodontally healthy applicants, smoking leads to statistically significant changes on the parameters in general; while the effect of smoking to the parameters was found insignificant in the CP groups. Findings of this study reveal the role of smoking on the development of periodontitis, due to negatively affecting the parameters linked to oxidative stress, that are crucial in the patogenesis of periodontal diseases. KEY WORDS: 8-hydroxy-2´-deoxyguanosine (8-OHdG), chronic periodontitis (CP), melatonin (MLT), myeloperoxidase (MPO), oxidative stres (OS), smoking, tobacco. Kronik Periodontitis Ve Sigara Kullananımının Oksidatif Durum Üzerine Olan Etkisinin Değerlendirilmesi Öz Amaç: Bu çalışmanın amacı; kronik periodontitisli ve periodontal açıdan sağlıklı bireylerin DOS ve tükürük numunelerinde sigaranın MLT, MPO ve 8-OHdG düzeyleri üzerine muhtemel etkilerinin değerlendirilmesidir. Gereç ve yöntem : Çalışma protokolü gereği her biri 15 katılımcıdan oluşan 4 grup oluşturuldu; periodontal olarak sağlıklı ve sigara içemeyen grup (P-S-), periodontal olarak sağlıklı ve sigara içen grup (P-S+), kronik periodontitisli ve sigara içmeyen grup (P+S-) ile kronik periodontitisli ve sigara içen grup (P+S+). DOS ve tükürük örnekleri alınmadan önce klinik periodontal parametreler kaydedildi. MLT, MPO ve 8-OHdG düzeyleri biyokimyasal ve olarak ölçüldü. Bulgular : En yüksek MPO ve 8-OHdGdüzeyleri ile en düşük MLT düzeyleri (P+S+) grubunda tespit edildi. En yüksek MLT düzeyi ise (P-S-) grubunda gözlendi. Sigara kullanımı ve kronik periodontitisin biyokimyasal ve histopatolojik parametreleri benzer şekilde etkilediği tespit edildi. Sonuç : KP’nin oksidatif stres ile ilişkili parametrelerde anlamlı düzeyde farklılık oluşturduğu gözlendi. Sigara kullanımının genel olarak periodontal sağlıklı bireylerde parametrelerde belirgin bir değişime yol açtığı, periodontitisli gruplarda ise bu değişimin istatistiksel olarak anlamlı olmadığı görüldü. Bulgularımız, sigara içmenin periodontal hastalıkların patogenezinde rol alan oksitatif parametreleri olumsuz yönde etkileyerek periodontitis gelişiminde rol oynayabileceğini göstermektedir. Anahtar Kelimeler: Isı şok proteinleri 60-70, kronik periodontitis, melatonin, myeloperoksidaz, oksitatif stress, sigara, 8-hydroxy-2'-deoxyguanosine.
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Birincil Dil en
Konular Diş Hekimliği
Bölüm Araştırma Makalesi
Yazarlar

Orcid: 0000-0001-9406-3368
Yazar: Didem ÖZKAL EMİNOĞLU
Kurum: ATATÜRK ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ
Ülke: Andorra


Orcid: 0000-0002-5314-0889
Yazar: Varol ÇANAKÇI
Kurum: ORDU ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ
Ülke: Andorra


Tarihler

Yayımlanma Tarihi : 15 Ekim 2020

Bibtex @araştırma makalesi { ataunidfd778795, journal = {Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi}, issn = {1300-9044}, eissn = {2667-5161}, address = {}, publisher = {Atatürk Üniversitesi}, year = {2020}, volume = {30}, pages = {536 - 544}, doi = {10.17567/ataunidfd.778795}, title = {EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY}, key = {cite}, author = {Özkal Eminoğlu, Didem and Çanakçı, Varol} }
APA Özkal Eminoğlu, D , Çanakçı, V . (2020). EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY . Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi , 30 (4) , 536-544 . DOI: 10.17567/ataunidfd.778795
MLA Özkal Eminoğlu, D , Çanakçı, V . "EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY" . Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 30 (2020 ): 536-544 <https://dergipark.org.tr/tr/pub/ataunidfd/issue/57792/778795>
Chicago Özkal Eminoğlu, D , Çanakçı, V . "EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY". Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 30 (2020 ): 536-544
RIS TY - JOUR T1 - EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY AU - Didem Özkal Eminoğlu , Varol Çanakçı Y1 - 2020 PY - 2020 N1 - doi: 10.17567/ataunidfd.778795 DO - 10.17567/ataunidfd.778795 T2 - Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi JF - Journal JO - JOR SP - 536 EP - 544 VL - 30 IS - 4 SN - 1300-9044-2667-5161 M3 - doi: 10.17567/ataunidfd.778795 UR - https://doi.org/10.17567/ataunidfd.778795 Y2 - 2020 ER -
EndNote %0 Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY %A Didem Özkal Eminoğlu , Varol Çanakçı %T EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY %D 2020 %J Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi %P 1300-9044-2667-5161 %V 30 %N 4 %R doi: 10.17567/ataunidfd.778795 %U 10.17567/ataunidfd.778795
ISNAD Özkal Eminoğlu, Didem , Çanakçı, Varol . "EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY". Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 30 / 4 (Ekim 2020): 536-544 . https://doi.org/10.17567/ataunidfd.778795
AMA Özkal Eminoğlu D , Çanakçı V . EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY. Ata Diş Hek Fak Derg. 2020; 30(4): 536-544.
Vancouver Özkal Eminoğlu D , Çanakçı V . EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2020; 30(4): 536-544.
IEEE D. Özkal Eminoğlu ve V. Çanakçı , "EVALUATİON OF OXİDATİVE STATUS İN PATİENTS WİTH CHRONİC PERİODONTİTİS AND ADDİTİONAL TOBACCO ABUSE: A CROSS-SECTİONAL STUDY", Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, c. 30, sayı. 4, ss. 536-544, Eki. 2020, doi:10.17567/ataunidfd.778795