Sepsis Oluşturmak İçin Kullanılan Deneysel Hayvan Modelleri

Öz

Sepsis, tüm vücutta enflamatuar bir durum ve bilinen veya şüphelenilen bir enfeksiyonun varlığı ile karakterize edilen ciddi bir durumdur. Vücut, bağışıklık sistemi tarafından kan, idrar, akciğerler, cilt veya diğer dokulardaki mikroplara karşı bu enflamatuar yanıtı geliştirebilir. Bu karmaşık patofizyolojinin sonuçları ciddi hipotansiyon, metabolik asidoz, doku hasarı ve çoklu organ yetmezliği, akut solunum sıkıntısı sendromu (ARDS) / akut akciğer hasarı (ALI) ve hatta ölüm gibi farklı şekillerde izlenebilir. Destek tedavileri, antibiyotikler, immünoterapi ajanları ve yeni tedavi seçeneklerine rağmen, sepsis %90’a varan yüksek mortalite oranı gösteren, yoğun bakım ünitelerinde ölüme en çok neden olan bir sağlık sorunu olarak karşımıza çıkmaktadır. Bu nedenle sepsis dünya üzerinde hem insanlarda en çok araştırma yapılan hastalıklardan birisidir, hem de deneysel hayvanlarda en çok çalışılan modellerden birisi olarak bilinmektedir. Aynı zamanda veteriner hekimlikte özellikle koyun gibi hayvanlarda görülen sepsis ve sepsise bağlı komplikasyonlar sıklıkla araştırılmaktadır. Hem klinik çalışma öncesi ilaçların hayvan deneylerinde mutlaka denenmesi ve incelenmesi gerekliliği, hem de hayvan refahını tehdit eden bir hastalık olması sebebiyle, bu yazıda sepsis oluşturmak için hayvanlarda kullanılan modeller (Lipopolisakkarit (LPS) gibi eksojen bir toksinin enjeksiyonu ile oluşturulan sepsis modeli, Fekal sepsis modelleri, eksojen bakterinin infüzyonu veya aşılanması ile oluşturulan sepsis modeli.) hakkında bilgi verilecektir.

Anahtar Kelimeler

• fare
• hayvan modelleri
• koyun
• sepsis
• sıçan

Experimental Animal Models for Sepsis

Öz

Sepsis is a serious condition characterized by an inflammatory condition throughout the body and the presence of a known or suspected infection. The body can improve this inflammatory response by its immune system to microbes in blood, urine, lungs, skin or other tissues. The results of this complex pathophysiology can be monitored in different ways, such as severe hypotension, metabolic acidosis, tissue damage and multiple organ failure, acute respiratory distress syndrome (ARDS) / acute lung injury (ALI), and even death. Despite supportive treatments, antibiotics, immunotherapy agents

and new treatment options, sepsis appears to be the most common health problem in intensive care units with a high mortality rate of up to 90%. For this reason, sepsis is known as both one of the most researched diseases in humans and one of the most studied models in experimental animals. At the same time, sepsis and complications related to sepsis are frequently investigated in veterinary medicine, especially in animals such as sheep. In this article, the information will be given about the models used in animals to create sepsis (Sepsis model created by injection of an exogenous toxin such as lipopolysaccharide (LPS), Fecal sepsis models, sepsis model created by infusion or inoculation of exogenous bacteria), both because of the necessity to try and examine the drugs before the clinical trial in animal experiments and as a disease that threatens animal welfare.

Anahtar Kelimeler

• Animal models
• Sepsis
• Mouse
• Rat
• Sheep

Kaynakça

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