Dogo Argentino Irkı Yavru Köpeklerde Izofluran ve Sevofluran'ın BAER ve Timpanometre Üzerindeki Etkilerinin Karşılaştırılması

Öz

İzofluran ve sevofluran, veteriner pratiğinde en sık kullanılan uçucu anestezik ajanlardır ancak beyin üzerindeki etkileri tam olarak anlaşılamamıştır. Bu çalışmada, stabil genel anestezi dönemlerinde kaydedilen beyin sapı işitsel uyarılmış yanıt (BAER) testi verilerinin sevofluran (%1.7) ve izofluranın (%2.1) spesifik MAK (Minimal Alveolar Konsantrasyon) değerlerinde karşılaştırılması amaçlanmıştır. Fiziki, video-otoskopik ve timpanometrik muayene sonuçlarına göre sağlıklı olarak değerlendirilen hastalar çalışmaya dahil edildi. Böylece detaylı ırka özgü referans timpanometrik değerler belirli yaş aralığında elde edildi. Çalışmada izofluran (n: 6) ve sevofluran (n: 6) ile anestezisi idame ettirilen 8-12 haftalık, 12 (9 erkek ve 3 dişi) Dogo Argentino ırkı köpek kullanıldı. Timpanometri verilerinin yanı sıra, BAER kayıtları iki grup arasındaki latans, amplitüd, V/I amplitüd oranı ve interpik latansları karşılaştırıldı. Veriler Student's t testi kullanılarak incelendi. İstatistiksel anlamlılık P<0.05 olarak belirlendi. Çalışma tasarımı prospektif, klinik, kör, çapraz çalışmadır. Sonuç olarak, izofluran grubunda bu çalışmada belirlenen MAK değerleri için beyin daha baskılanmış görünmektedir ancak timpanometri değerleri etkilenmemiştir.

Anahtar Kelimeler

• Anastezi
• BAER
• Dogo argentino
• MAK
• Timpanometri

Comparison of the Effects of Isoflurane and Sevoflurane on BAER and Tympanometry in Dogo Argentino Breed Puppies

Öz

Isoflurane and sevoflurane are the most frequently used volatile anesthetic agents in veterinary practice yet their effects on the brain are not fully understood. In this study, it was aimed to compare the brainstem auditory evoked response (BAER) test data recorded during stable general anesthesia periods in specific MAC (Minimal Alveolar Concentration) values of sevoflurane (1.7%) and isoflurane (2.1%). The patients who were evaluated as healthy according to physical, video-otoscopy, and tympanometry examination results were included in the study. Thus, detailed breed specific reference tympanometric values were obtained in a certain age range. In the study, 12 (9 male and 3 female) Dogo Argentino breed, 8-12 weeks old, healthy dogs were used, which were maintained with anesthesia with isoflurane (n: 6) and sevoflurane (n: 6). As well as tympanometry data, the latency, amplitude, V/I amplitude ratio, and interpeak latencies between the two groups BAER records were compared. Data were analyzed using Student's t-test. Statistical significance was determined as P<0.05. The study design is prospective, clinical, blind, cross-study. In conclusion, the brain appears to be more suppressed for the minimal alveolar concentration values determined in this study in the isoflurane group, but tympanometry values were not affected.

Anahtar Kelimeler

• Anasthesia
• BAER
• Dogo argentino
• MAC
• Tympanometry

Kaynakça

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