Diyabetik Yaraların İyileşmesinde Bazı Glikozaminoglikan Maddelerin (Kitosan ve Hyaluronan) Etkilerinin Karşılaştırılması*

Yıl 2016, Cilt: 11 Sayı: 2, 0 - 0, 31.10.2016

Nazmi Atasoy Fulya Tuygun

https://doi.org/10.17094/avbd.87059

Öz

Bu çalışma, diyabetik yaralarada chitosan ve hyaluronan etkilerinin karşılaştırılmasını amaçladı. Çalışma toplam kırk Yeni Zelenda tavşanı üzerinde yürütüldü. Tavşanlarda diyabet iki gün arayla iki defa 60 mg/kg dozda alloxan monohidrat uygulaması ile oluşturuldu. Anestezi altında tüm hayvanların bel bölgesinde iki adet 2 cm çapında dairesel tam kat deri yarası oluşturuldu. Çalışma grubundaki hayvanların yaralarından bir tanesine hyaluronan diğerine ise kitosan uygulandı. Post operatif 3., 6., 9., 11. ve 15. günlerde yara iyileşmesi makroskobik ve histopatolojik olarak incelendi ve yara kontraksiyon oranları ölçüldü. Sonuç olarak, ilk on günde kitosanın daha sonraki günlerde ise hyaluranın diyabetli yara iyileşmesine olumlu katkı sağladıkları saptandı.

Anahtar Kelimeler

Diyabetik yara iyileşmesi, Hyaluronan, Kitosan

Kaynakça

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