Koenzim Q ve Hastalıklar ile İlişkisi

Yıl 2016, Cilt: 11 Sayı: 2, 0 - 0, 31.10.2016

Serkan Sayıner Görkem Kısmalı

https://doi.org/10.17094/avbd.96215

Cited By: 1

Öz

 

 Koenzim Q (2-metil-5, 6 dimetoksi-1, 4-benzokinon, KoQ, Ubikinon, UQ) tüm hücrelerde ve membranlarda bulunan, başlıca mitokondriyal solunum zincirinde kilit rol oynayan ve hücre metabolizması için son derece önemli bir moleküldür. Koenzim Q, güçlü lipofilik bir antioksidan olarak lipoproteinleri ve hücre membranlarını korumaktadır. İlk zamanlar ağırlıklı olarak redoks fonksiyonu üzerinde koenzim Q ile ilgili çalışmalar yapılmış olup, son 20 yıldır farklı fonksiyonları da tespit edilmiştir. Bunlar arasında antioksidatif sistemdeki rolü, lenfosit ve monositler üzerindeki etkisi, endotelyal fonksiyonu, hücre sinyali ve gen ifadesindeki rolü yer almakta ve bu fonksiyonları üzerinde de çalışmalar yapılmaktadır. Koenzim Q düzeyleri yaşlanma ve hastalık durumlarına bağlı olarak değişiklik göstermektedir. Günümüzde beşeri alanda gerek tanı, gerekse tedavi süreci konusunda ilişkili olduğu hastalıklar üzerinde yapılan çalışmalar yoğunluk kazanmıştır. Koenzim Q ile en çok ilişkilendirilen hastalıklar arasında kardiyovasküler hastalıklar, dejeneratif kas hastalıkları, kemik hastalıkları, kanserler, diabetes mellitus ve nörodejeneratif hastalıklar (Huntington hastalığı, Parkinson hastalığı, Alzheimer hastalığı) sayılabilir. Sağlık veya hastalık durumu ile koenzim Q’ nun ilişkilendirilmesi önemlidir. Bu derlemede, koenzim Q’ nun bilinen fonksiyonları ve hastalıkları ile olan ilişkisi ile ilgili güncel bilgiler sunulmuştur.

Anahtar Kelimeler

Antioksidan, Hastalık, Koenzim Q

Kaynakça

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