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Bipolar Bozuklukta Sosyal Ritim ve Sosyal Ritmi Düzenlemeye Yönelik Müdahaleler

Yıl 2026, Cilt: 9 Sayı: 1, 25 - 39, 16.03.2026
https://izlik.org/JA56NZ26DE

Öz

Bu derlemede, bipolar bozuklukta semptomları azaltmak, uykuyu düzenlemek ve işlevselliği artırmak için sosyal ritimleri ele alan müdahaleleri derlemek amaçlanmıştır. Bipolar bozuklukta nüksü etkileyen faktörler; stresli yaşam olayları, ilaç tedavisine uyumsuzluk ve sosyal ritimlerdeki bozulmalardır. Kronoterapötik müdahalalerden olan parlak ışık terapisi ile ilgili tutarsız sonuçlar olsa da bipolar bozukluğun özellikle depresif dönemlerinde etkili ve güvenli bir tamamlayıcı müdahale yöntemi olabileceği görülmektedir. Öte yandan, manik dönemlerde uygulanan karanlık terapisi ve mavi ışık filtreleyici gözlük kullanımı gibi müdahalelerin, manik semptomlarda azalma sağladığı, uyku kalitesini artırdığı ve farmakolojik tedavi gereksinimini azalttığı bulunmuştur. Psikoterapötik müdahaleler incelendiğinde ise, BDT-I uygulandıktan sonra, depresyon remisyon oranının daha yüksek olduğu, anksiyolitik kullanımında, uykusuzluk şiddetinde ve uykuya ilişkin olumsuz düşüncelerde azalma olduğu belirlenmiştir. BDTI-BD ise bipolar bozukluk tanısı olan bireylerde uykusuzluk şiddeti, manik/hipomanik atakların sıklığını ve uyku için psikotrop ilaç kullanımını azaltmıştır. Kişilerarası ilişkiler ve Sosyal Ritim Terapisinin de (KİSRT) hem bireysel hem de grup formatında uygulanarak, depresif ve manik semptomlarda azalma, sosyal ritim düzenliliğinde iyileşme ve işlevsellikte artış sağlayabildiği görülmektedir. Sonuç olarak, sirkadiyen ritmi hedef alan yaklaşımlar, özellikle farmakolojik tedavilere direnç gösteren bipolar bozukluk olgularında, hızlı etki göstermesi ve nörobiyolojik temellere dayanması açısından umut vaat etmektedir. Ancak, daha geniş örneklemli, müdahale protokollerinin standardizasyonu ve klinik etkilerin uzun dönem takibi gibi alanlarda daha fazla bilimsel veri gereklidir.

Kaynakça

  • Frank E, Swartz HA, Boland E Interpersonal and social rhythm therapy: an intervention addressing rhythm dysregulation in bipolar disorder. Dialogues in Clinical Neuroscience 2007;9,325–332.
  • Nierenberg, A, Agustini B, Köhler-Forsberg O, Cusin C, Katz, D, Sylvia LG., ... & Berk M. Diagnosis and treatment of bipolar disorder: a review. Jama 2023;330(14), 1370-1380.
  • Post RM, Leverich GS. The role of psychosocial stress in the onset and progression of bipolar disorder and its comorbidities: The need for earlier and alternative modes of therapeutic intervention. Dev Psychopathol 2006;18, 1181–1211.
  • Malkoff‑Schwartz S, Frank E, Anderson BP, Hlastala SA, Luther JF, Sherrill JT, Houck PR, Kupfer DJ. Social rhythm disruption and stressful life events in the onset of bipolar and unipolar episodes. Psychol Med 2000;30(5):1005–16.
  • Crowe M, Whitehead L, Wilson L, et al. Disorder-specific psychosocial interventions for bipolar disorder – a systematic review of the evidence for mental health nursing practice. International Journal of Nursing Studies 2010;47, 896–908.
  • Gıca Ş, Selvi Y. Şizofreni ve Bipolar Bozukluğun Tedavisinde Uyku Alanında Müdahaleler. Archives of Neuropsychiatry/ Noropsikiatri Arsivi 2021;58,53-60.
  • Gottlieb JF, Benedetti F, Geofroy P, et al.The chronotherapeutic treatment of bipolar disorders:A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology. Bipolar Disorders 2019; 21:741– 773.
  • Sylvia LG, Alloy LB, Hafner JA, Gauger MC, Verdon K, Abramson LY. Life events and social rhythms in bipolar spectrum disorders. J Affect Disord 2009;113(1‑2):117– 25.
  • Ehlers C.L, Frank E, Kupfer D.J. Social zeitgebers and biological rhythms. A unified approach to understanding the etiology of depression. Archives of General Psychiatry 1988;45, 948–952.
  • Boland E.M, Bender R.E, Alloy L.B, et al. Life events and social rhythms in bipolar spec- trum disorders: an examination of social rhythm sensitivity. Journal of Affective Disorders 2012;139, 264–272.
  • Zou H, Zhou H, Yan R, Yao Z, Lu Q. Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms. Frontiers in neuroscience 2022; 16, 811771.
  • Grandin, LD, Alloy LB, Abramson LY. The social zeitgeber theory, circadianrhythms, and mood disorders: Review and evaluation. Clinical Psychology Review 2006;26 (6), 679–694. https://doi.org/10.1016/j. cpr.2006.07.001.
  • Rosenthal NE, Sack DA, Gillin JC, et al. Seasonal affective disorder: a description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry 1984;41:72-80.
  • Al-Karawi D, Jubair L. Bright light therapy for nonseasonal depression: Metaanalysis of clinicaltrials.JAffectDisord 2016;198:65-71.
  • Terman M, Terman JS. Light therapy for seasonal and nonseasonal depression: efficacy, protocol, safety, and side effects. CNS Spectr 2005;10:647-663.
  • Zhou TH, Dang WM, Ma YT, et al. Clinical efficacy, onset time and safety of bright light therapy in acute bipolar depression as an adjunctive therapy: a randomized controlled trial. Journal of affective disorders 2018;227, 90-96.
  • Sit DK, McGowan J, Wiltrout C, et al. Adjunctive bright light therapy for bipolar depression: a randomized double-blind placebo-controlled trial. American Journal of Psychiatry 2018;175(2), 131-139.
  • Kupeli, NY, Bulut NS, Bulut GC, et al. Efficacy of bright light therapy in bipolar depression. Psychiatry research 2018;260, 432-438.
  • Benedetti F, Dallaspezia S, Fulgosi MC, et al. Phase advance is an actimetric correlate of antidepressant response to sleep deprivation and light therapy in bipolar depression. Chronobiology International 2007;24, 921–937.
  • Legenbauer T, Kirschbaum-Lesch I, Jörke C, et al. Bright light therapy as add-on to inpatient treatment in youth with moderate to severe depression: a randomized clinical trial. JAMA psychiatry 2024;81(7), 655- 662.
  • Chojnacka M, Antosik-Wójcińska AZ, Dominiak M, et al. A sham controlled randomized trial of adjunctive light therapy for non- seasonal depression. J Affect Disord 2016;203:1-8.
  • Phelps J. Dark therapy for bipolar disorder using amber lenses for blue light blockade. Med Hypotheses, 2008;70:224–229.
  • Harvey AG, Soehner AM, Kaplan KA, et al. Treating insomnia improves mood state, sleep, and functioning in bipolar disorder: A pilot randomized controlled trial. J Consult Clin Psychol 2015;83:564–577.
  • Hester L, Dang D, Barker CJ, Heath M, Mesiya S, Tienabeso T, Watson K. Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Chronobiology International 2021;38(10), 1375-1383.
  • Henriksen TE, Skrede S, Fasmer OB, et al. Blue-blocking glasses as additive treatment for mania: a randomized placebo-controlled trial. Bipolar Disord 2016;18(3):221–32.
  • Henriksen TE, Grønli J, Assmus J. et al. Blue-blocking glasses as additive treatment for mania: effects on actigraphyderived sleep parameters. Journal of sleep research 2020;29(5), e12984.
  • Barbini B, Bendetti F, Colombo A, et al. Dark therapy for mania: a pilot study. Bipolar Disorders 2005;7:98–101.
  • Swanson LM, Schubert JR, Raglan GB, Conroy DA. Chronotherapeutic treatments for psychiatric disorders: a narrative review of recent literature. Current Psychiatry Reports 2025;1-15.
  • Wirz-Justice A. Biological rhythms and depression: treatment opportunities. WPA Bulletin on Depression 2008;12:5-8.
  • Gottlieb JF, Goel N, Chen S, et al. Metaanalysis of sleep deprivation in the acute treatment of bipolar depression. Acta Psychiatrica Scandinavica 2021;143(4), 319- 327.
  • Ramirez-Mahaluf JP, Rozas-Serri E, Ivanovic- Zuvic F, et al. Effectiveness of sleep deprivation in treating acute bipolar depression as augmentation strategy: a systematic review and meta-analysis. Frontiers in Psychiatry 2020;11, 70.
  • Barbini B, Colombo C, Benedetti F, et al.The unipolar–bipolar dichotomy and the response to sleep deprivation. Psychiatry Research 1998;79(1), 43-50.
  • Benedetti F, Campori E, Barbini B, et al. Dopaminergic augmentation of sleep deprivation effects in bipolar depression. Psychiatry Research 2001;104(3), 239-246.
  • Colombo C, Lucca A, Benedetti F, et al. Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction. Psychiatry research 2000;95(1), 43-53.
  • Wu JC, Kelsoe JR, Schachat C, et al. Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder. Biological psychiatry, 2009;66(3), 298-301.
  • Sikkens D, Riemersma-Van der Lek RF, Meesters Y, et al. Combined sleep deprivation and light therapy: Clinical treatment outcomes in patients with complex unipolar and bipolar depression. Journal of Affective Disorders 2019;246, 727-730.
  • D'Agostino A, Ferrara P, Terzoni S, et al. Efficacy of triple chronotherapy in unipolar and bipolar depression: a systematic review of the available evidence. Journal of Affective Disorders 2020;276, 297-304.
  • Yin L, Wang J, Klein PS, et al. Nuclear receptor Rev-erbα is a critical lithium-sensitive component of the circadian clock. Science 2006;311(5763):1002-5.
  • Claustrat B, Brun J, Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Med Rev 2005;9(1):11-24.
  • Perumal S, Srinivasan V, Maestroni G, et al. Melatonin: nature's most versatile biological signal? The FEBS J 2006;273(13):2813- 2838.
  • Racagni G, Riva MA, Popoli M. The interaction between the internal clock and antidepressant efficacy. Int Clin Psychopharmacol 2007;22 Suppl 2:S9–S14.
  • Li X, Yu J, Jiang S, et al. Circadian rhythms of melatonin and its relationship with anhedonia in patients with mood disorders: a cross-sectional study. BMC psychiatry 2024;24(1), 165.
  • Mahableshwarkar AR, Calabrese JR, Macek TA., et al. Efficacy and safety of sublingual ramelteon as an adjunctive therapy in the maintenance treatment of bipolar I disorder in adults: a phase 3, randomized controlled trial. Journal of Affective Disorders 2017;221, 275-282.
  • Kishi T, Nomura I, Sakuma K, et al. Melatonin receptor agonists—ramelteon and melatonin—for bipolar disorder: a systematic review and meta-analysis of double- blind, randomized, placebo-controlled trials. Neuropsychiatric disease and treatment 2019;1479-1486.
  • Moghaddam HS, Bahmani S, Bayanati S, et al. Efficacy of melatonin as an adjunct in the treatment of acute mania: a doubleblind and placebo-controlledtrial. International Clinical Psychopharmacology 2020;35(2), 81-88.
  • Quested DJ, Gibson JC, Sharpley AL, et al. Melatonin In Acute Mania Investigation (MIAMI-UK). A randomized controlled trial of add-on melatonin in bipolar disorder. Bipolar Disorders 2021;23(2), 176- 185.
  • Bersani G, Garavini A. Melatonin add-on in manic patients with treatment resistant insomnia. Prog Neuropsychopharmacol Biol Psychiatry 2000;24(2):185-191.
  • Romo-Nava F, Gonzlez D, Orellana AF, et al. Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, doubleblind, parallel-group, placebocontrolled clinical trial. Bipolar Disord 2014;16(4):410-421.
  • Hertenstein E, Trinca E, Wunderlin M, et al. Cognitive behavioral therapy for insomnia in patients with mental disorders and comorbid insomnia: A systematic review and meta-analysis. Sleep medicine reviews 2022; 62, 101597.
  • Neubauer DN, Pandi-Perumal SR, Spence DW, et al. Pharmacotherapy of insomnia. J CentNervSystDis, 2018 10:1179573518770672.
  • Smith MT, Perlis ML, Park A, et al. Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry 2002;159:5–11.
  • Morse CD, Klingman KJ, Jacob BL, et al. Exercise and ıinsomnia risk in middle-aged women. J Nurse Pract 2019;15:236-240.
  • Randall C, Nowakowski S, Ellis JG. Managing acute insomnia in prison: evaluation of a “one-shot” cognitive behavioral therapy for insomnia (CBT-I) intervention. Behav Sleep Med 2019;17:827-836.
  • Çıvgın U, Dirik G. Bilişsel Davranışçı Terapi-Uykusuzluk Protokolü ve Etkililik Çalışmalarının Gözden Geçirilmesi. Psikiyatride Güncel Yaklaşımlar 2020;12(2), 274-286.
  • Jansson-Fröjmark M, Norell-Clarke A. Cognitive behavioural therapy for insomnia in psychiatric disorders. Current sleep medicine reports 2016;2(4), 233-240.
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Social Rhythm in Bipolar Disorder and Interventions to Regulate Social Rhythm

Yıl 2026, Cilt: 9 Sayı: 1, 25 - 39, 16.03.2026
https://izlik.org/JA56NZ26DE

Öz

This review aims to compile interventions targeting social rhythms to reduce symptoms, regulate sleep, and improve functioning in bipolar disorder. Factors influencing relapse in bipolar disorder include stressful life events, nonadherence to pharmacological treatment, and disruptions in social rhythms. Although the findings are inconsistent, bright light therapy, as a chronotherapeutic intervention, appears to be an effective and safe adjunctive treatment, particularly during depressive episodes of bipolar disorder. On the other hand, interventions implemented during manic episodes, such as dark therapy and the use of blue light-blocking glasses, have been found to reduce manic symptoms, improve sleep quality, and decrease the need for pharmacological treatment. In terms of psychotherapeutic interventions, CBT-I has been associated with higher depression remission rates, reduced use of anxiolytics, decreased insomnia severity, and fewer maladaptive sleep-related cognitions. Furthermore, CBT-I adapted for bipolar disorder (CBT-I-BD) has been shown to reduce insomnia severity, the frequency of manic/hypomanic episodes, and the use of psychotropic medication for sleep among individuals diagnosed with BD. Interpersonal and Social Rhythm Therapy (IPSRT), whether delivered individually or in group formats, has been found to reduce both depressive and manic symptoms, improve social rhythm regularity, and enhance overall functioning. In conclusion, approaches targeting circadian rhythms show promise, particularly in treatment-resistant cases of bipolar disorder, due to their rapid effects and neurobiological basis. However, further scientific data are needed, especially in areas such as standardized intervention protocols, larger sample sizes, and long-term follow-up of clinical outcomes.

Kaynakça

  • Frank E, Swartz HA, Boland E Interpersonal and social rhythm therapy: an intervention addressing rhythm dysregulation in bipolar disorder. Dialogues in Clinical Neuroscience 2007;9,325–332.
  • Nierenberg, A, Agustini B, Köhler-Forsberg O, Cusin C, Katz, D, Sylvia LG., ... & Berk M. Diagnosis and treatment of bipolar disorder: a review. Jama 2023;330(14), 1370-1380.
  • Post RM, Leverich GS. The role of psychosocial stress in the onset and progression of bipolar disorder and its comorbidities: The need for earlier and alternative modes of therapeutic intervention. Dev Psychopathol 2006;18, 1181–1211.
  • Malkoff‑Schwartz S, Frank E, Anderson BP, Hlastala SA, Luther JF, Sherrill JT, Houck PR, Kupfer DJ. Social rhythm disruption and stressful life events in the onset of bipolar and unipolar episodes. Psychol Med 2000;30(5):1005–16.
  • Crowe M, Whitehead L, Wilson L, et al. Disorder-specific psychosocial interventions for bipolar disorder – a systematic review of the evidence for mental health nursing practice. International Journal of Nursing Studies 2010;47, 896–908.
  • Gıca Ş, Selvi Y. Şizofreni ve Bipolar Bozukluğun Tedavisinde Uyku Alanında Müdahaleler. Archives of Neuropsychiatry/ Noropsikiatri Arsivi 2021;58,53-60.
  • Gottlieb JF, Benedetti F, Geofroy P, et al.The chronotherapeutic treatment of bipolar disorders:A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology. Bipolar Disorders 2019; 21:741– 773.
  • Sylvia LG, Alloy LB, Hafner JA, Gauger MC, Verdon K, Abramson LY. Life events and social rhythms in bipolar spectrum disorders. J Affect Disord 2009;113(1‑2):117– 25.
  • Ehlers C.L, Frank E, Kupfer D.J. Social zeitgebers and biological rhythms. A unified approach to understanding the etiology of depression. Archives of General Psychiatry 1988;45, 948–952.
  • Boland E.M, Bender R.E, Alloy L.B, et al. Life events and social rhythms in bipolar spec- trum disorders: an examination of social rhythm sensitivity. Journal of Affective Disorders 2012;139, 264–272.
  • Zou H, Zhou H, Yan R, Yao Z, Lu Q. Chronotype, circadian rhythm, and psychiatric disorders: Recent evidence and potential mechanisms. Frontiers in neuroscience 2022; 16, 811771.
  • Grandin, LD, Alloy LB, Abramson LY. The social zeitgeber theory, circadianrhythms, and mood disorders: Review and evaluation. Clinical Psychology Review 2006;26 (6), 679–694. https://doi.org/10.1016/j. cpr.2006.07.001.
  • Rosenthal NE, Sack DA, Gillin JC, et al. Seasonal affective disorder: a description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry 1984;41:72-80.
  • Al-Karawi D, Jubair L. Bright light therapy for nonseasonal depression: Metaanalysis of clinicaltrials.JAffectDisord 2016;198:65-71.
  • Terman M, Terman JS. Light therapy for seasonal and nonseasonal depression: efficacy, protocol, safety, and side effects. CNS Spectr 2005;10:647-663.
  • Zhou TH, Dang WM, Ma YT, et al. Clinical efficacy, onset time and safety of bright light therapy in acute bipolar depression as an adjunctive therapy: a randomized controlled trial. Journal of affective disorders 2018;227, 90-96.
  • Sit DK, McGowan J, Wiltrout C, et al. Adjunctive bright light therapy for bipolar depression: a randomized double-blind placebo-controlled trial. American Journal of Psychiatry 2018;175(2), 131-139.
  • Kupeli, NY, Bulut NS, Bulut GC, et al. Efficacy of bright light therapy in bipolar depression. Psychiatry research 2018;260, 432-438.
  • Benedetti F, Dallaspezia S, Fulgosi MC, et al. Phase advance is an actimetric correlate of antidepressant response to sleep deprivation and light therapy in bipolar depression. Chronobiology International 2007;24, 921–937.
  • Legenbauer T, Kirschbaum-Lesch I, Jörke C, et al. Bright light therapy as add-on to inpatient treatment in youth with moderate to severe depression: a randomized clinical trial. JAMA psychiatry 2024;81(7), 655- 662.
  • Chojnacka M, Antosik-Wójcińska AZ, Dominiak M, et al. A sham controlled randomized trial of adjunctive light therapy for non- seasonal depression. J Affect Disord 2016;203:1-8.
  • Phelps J. Dark therapy for bipolar disorder using amber lenses for blue light blockade. Med Hypotheses, 2008;70:224–229.
  • Harvey AG, Soehner AM, Kaplan KA, et al. Treating insomnia improves mood state, sleep, and functioning in bipolar disorder: A pilot randomized controlled trial. J Consult Clin Psychol 2015;83:564–577.
  • Hester L, Dang D, Barker CJ, Heath M, Mesiya S, Tienabeso T, Watson K. Evening wear of blue-blocking glasses for sleep and mood disorders: a systematic review. Chronobiology International 2021;38(10), 1375-1383.
  • Henriksen TE, Skrede S, Fasmer OB, et al. Blue-blocking glasses as additive treatment for mania: a randomized placebo-controlled trial. Bipolar Disord 2016;18(3):221–32.
  • Henriksen TE, Grønli J, Assmus J. et al. Blue-blocking glasses as additive treatment for mania: effects on actigraphyderived sleep parameters. Journal of sleep research 2020;29(5), e12984.
  • Barbini B, Bendetti F, Colombo A, et al. Dark therapy for mania: a pilot study. Bipolar Disorders 2005;7:98–101.
  • Swanson LM, Schubert JR, Raglan GB, Conroy DA. Chronotherapeutic treatments for psychiatric disorders: a narrative review of recent literature. Current Psychiatry Reports 2025;1-15.
  • Wirz-Justice A. Biological rhythms and depression: treatment opportunities. WPA Bulletin on Depression 2008;12:5-8.
  • Gottlieb JF, Goel N, Chen S, et al. Metaanalysis of sleep deprivation in the acute treatment of bipolar depression. Acta Psychiatrica Scandinavica 2021;143(4), 319- 327.
  • Ramirez-Mahaluf JP, Rozas-Serri E, Ivanovic- Zuvic F, et al. Effectiveness of sleep deprivation in treating acute bipolar depression as augmentation strategy: a systematic review and meta-analysis. Frontiers in Psychiatry 2020;11, 70.
  • Barbini B, Colombo C, Benedetti F, et al.The unipolar–bipolar dichotomy and the response to sleep deprivation. Psychiatry Research 1998;79(1), 43-50.
  • Benedetti F, Campori E, Barbini B, et al. Dopaminergic augmentation of sleep deprivation effects in bipolar depression. Psychiatry Research 2001;104(3), 239-246.
  • Colombo C, Lucca A, Benedetti F, et al. Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction. Psychiatry research 2000;95(1), 43-53.
  • Wu JC, Kelsoe JR, Schachat C, et al. Rapid and sustained antidepressant response with sleep deprivation and chronotherapy in bipolar disorder. Biological psychiatry, 2009;66(3), 298-301.
  • Sikkens D, Riemersma-Van der Lek RF, Meesters Y, et al. Combined sleep deprivation and light therapy: Clinical treatment outcomes in patients with complex unipolar and bipolar depression. Journal of Affective Disorders 2019;246, 727-730.
  • D'Agostino A, Ferrara P, Terzoni S, et al. Efficacy of triple chronotherapy in unipolar and bipolar depression: a systematic review of the available evidence. Journal of Affective Disorders 2020;276, 297-304.
  • Yin L, Wang J, Klein PS, et al. Nuclear receptor Rev-erbα is a critical lithium-sensitive component of the circadian clock. Science 2006;311(5763):1002-5.
  • Claustrat B, Brun J, Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Med Rev 2005;9(1):11-24.
  • Perumal S, Srinivasan V, Maestroni G, et al. Melatonin: nature's most versatile biological signal? The FEBS J 2006;273(13):2813- 2838.
  • Racagni G, Riva MA, Popoli M. The interaction between the internal clock and antidepressant efficacy. Int Clin Psychopharmacol 2007;22 Suppl 2:S9–S14.
  • Li X, Yu J, Jiang S, et al. Circadian rhythms of melatonin and its relationship with anhedonia in patients with mood disorders: a cross-sectional study. BMC psychiatry 2024;24(1), 165.
  • Mahableshwarkar AR, Calabrese JR, Macek TA., et al. Efficacy and safety of sublingual ramelteon as an adjunctive therapy in the maintenance treatment of bipolar I disorder in adults: a phase 3, randomized controlled trial. Journal of Affective Disorders 2017;221, 275-282.
  • Kishi T, Nomura I, Sakuma K, et al. Melatonin receptor agonists—ramelteon and melatonin—for bipolar disorder: a systematic review and meta-analysis of double- blind, randomized, placebo-controlled trials. Neuropsychiatric disease and treatment 2019;1479-1486.
  • Moghaddam HS, Bahmani S, Bayanati S, et al. Efficacy of melatonin as an adjunct in the treatment of acute mania: a doubleblind and placebo-controlledtrial. International Clinical Psychopharmacology 2020;35(2), 81-88.
  • Quested DJ, Gibson JC, Sharpley AL, et al. Melatonin In Acute Mania Investigation (MIAMI-UK). A randomized controlled trial of add-on melatonin in bipolar disorder. Bipolar Disorders 2021;23(2), 176- 185.
  • Bersani G, Garavini A. Melatonin add-on in manic patients with treatment resistant insomnia. Prog Neuropsychopharmacol Biol Psychiatry 2000;24(2):185-191.
  • Romo-Nava F, Gonzlez D, Orellana AF, et al. Melatonin attenuates antipsychotic metabolic effects: an eight-week randomized, doubleblind, parallel-group, placebocontrolled clinical trial. Bipolar Disord 2014;16(4):410-421.
  • Hertenstein E, Trinca E, Wunderlin M, et al. Cognitive behavioral therapy for insomnia in patients with mental disorders and comorbid insomnia: A systematic review and meta-analysis. Sleep medicine reviews 2022; 62, 101597.
  • Neubauer DN, Pandi-Perumal SR, Spence DW, et al. Pharmacotherapy of insomnia. J CentNervSystDis, 2018 10:1179573518770672.
  • Smith MT, Perlis ML, Park A, et al. Comparative meta-analysis of pharmacotherapy and behavior therapy for persistent insomnia. Am J Psychiatry 2002;159:5–11.
  • Morse CD, Klingman KJ, Jacob BL, et al. Exercise and ıinsomnia risk in middle-aged women. J Nurse Pract 2019;15:236-240.
  • Randall C, Nowakowski S, Ellis JG. Managing acute insomnia in prison: evaluation of a “one-shot” cognitive behavioral therapy for insomnia (CBT-I) intervention. Behav Sleep Med 2019;17:827-836.
  • Çıvgın U, Dirik G. Bilişsel Davranışçı Terapi-Uykusuzluk Protokolü ve Etkililik Çalışmalarının Gözden Geçirilmesi. Psikiyatride Güncel Yaklaşımlar 2020;12(2), 274-286.
  • Jansson-Fröjmark M, Norell-Clarke A. Cognitive behavioural therapy for insomnia in psychiatric disorders. Current sleep medicine reports 2016;2(4), 233-240.
  • Chung KF, Yeung WF, Ho FY, et al. Cognitive behavioural therapy for insomnia as an early intervention of mood disorders with comorbid insomnia: a randomized controlled trial. Early Interv Psychiatry 2024;18(2):82–93.
  • Ugurlu M, Karakas Ugurlu G, Kabadayi Sahin E, et al. Short and long-term effects of cognitive behavioral therapy on sleep problems and psychotic symptoms in patients with psychotic disorders: a metaanalysis. Brazilian Journal of Psychiatry 2025;47, e20243623.
  • Swagemakers O, Nugter A, Engelsbel F, et al. Feasibility of group cognitive behavioural therapy for insomnia (CBT-I) in bipolar disorder. European Psychiatry 2021;64(S1), S195-S196.
  • Frank E, Kupfer DJ, Thase ME, et al. Twoyear outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder. Archives of General Psychiatry 2005;62(9), 996-1004.
  • Goldstein TR, Merranko J, Krantz M, et al.Early intervention for adolescents at-risk for bipolar disorder: A pilot randomized trial of Interpersonal and Social Rhythm Therapy (IPSRT). Journal of affective disorders 2018;235,348-356.
  • Hızlı Sayar G, Özten E, Ünsalver B. Bipolar bozuklukta kişilerarası ilişkiler ve sosyal ritim terapisinin temel ilkeleri. Psikiyatride Güncel Yaklaşımlar 2014;6(4),438-446.
  • Frank E, Swartz H. A, Kupfer DJ. Interpersonal and social rhythm therapy: managing the chaos of bipolar disorder. Biol Psychiatry 2000;48, 593–604.
  • Frank E. Interpersonal and social rhythm therapy: a means of improving depression and preventing relapse in bipolar disorder. Journal of Clinical Psychology 2007;463- 473. https://doi.org/10.1002/jclp.20371.
  • Swartz HA, Frank E, Cheng YA. Randomized pilot study of psychotherapy and quetiapine for the acute treatment of bipolar II depression. Bipolar Disorders 2012;14, 211–216.
  • Inder M, Crowe MT, Luty SE. Randomized, controlled trial of ınterpersonal and social rhythm therapy for young people with bipolar disorder. Bipolar Disorders 2015;17(2), (s.128-138). doi: 10.1111/ bdi.12273.
  • Inder ML, Crowe MT, Moor S, et al. Three-year follow-up after psychotherapy for young people with bipolar disorder. Bipolar Disord 2017;22. doi: 10.1111/ bdi.12582.
  • Bouwkamp CG, de Kruiff ME, van Troost TM, et al. Interpersonal and social rhythm group therapy for patients with bipolar disorder. Int J Group Psychother 2013;63(1):97–115.
  • Hoberg AA, Ponto J, Nelson PJ, et al. Group interpersonal and social rhythm therapy for bipolar depression. Perspect Psychiatr Care 2013;49(4):226–34.
  • Crowe M, Porter R, Inder M, et al. Clinical effectiveness trial of adjunctive ınterpersonal and social rhythm therapy for patients with bipolar disorder. Am J Psychother 2020;1:73(3),107-114.
  • Crowe M, Inder M, Douglas K, et al. Interpersonal and social rhythm therapy for patients with major depressive disorder. American journal of psychotherapy 2020;73(1), 29-34.
  • Moot W, Crowe M, Inder M, et al. Functional and mood outcomes in bipolar disorder patients with and without substance use disorders undergoing psychotherapy. Frontiers in psychiatry 2021;12, 661458.
  • Steardo L, Luciano M, Sampogna G, et al.Efficacy of the interpersonal and social rhythm therapy (IPSRT) in patients with bipolar disorder: results from a real-world, controlled trial. Annals of general psychiatry 2020;19, 1-7.
Toplam 72 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Psikiyatri
Bölüm Derleme
Yazarlar

Yeşim Ayar 0000-0002-7248-5946

Tuğba Şahin Tokatlıoğlu 0000-0003-2569-9906

Gönderilme Tarihi 2 Eylül 2025
Kabul Tarihi 5 Ocak 2026
Yayımlanma Tarihi 16 Mart 2026
IZ https://izlik.org/JA56NZ26DE
Yayımlandığı Sayı Yıl 2026 Cilt: 9 Sayı: 1

Kaynak Göster

APA Ayar, Y., & Şahin Tokatlıoğlu, T. (2026). Social Rhythm in Bipolar Disorder and Interventions to Regulate Social Rhythm. Tıp Fakültesi Klinikleri Dergisi, 9(1), 25-39. https://izlik.org/JA56NZ26DE


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