Endometrial Kanserde Metformin Kullanımı

Öz

Endometrial kanser (EK) gelişmiş ülkelerde kadın genital sisteminin en sık görülen kanseridir. Önemli risk faktörleri olan obezite, Tip 2 Diabetes Mellitus ve insülin direncinin artışı ile birlikte tüm dünyada EK insidensi ve etkilenen genç hasta sayısı giderek artmaktadır. EK’de temel tedavi seçeneği olan cerrahi, fertiliteyi sonlandırması nedeni ile genç hastaları olumsuz olarak etkilemektedir. Ayrıca mevcut tedavi seçenekleri ileri evre ve rekürren EK’li hastalarda yetersiz kalmaktadır. Bu nedenle EK’li hastalar için yeni, etkili, cerrahi olmayan ve konservatif tedavi seçenekleri geliştirilmesi zorunlu görünmektedir. Bu açıdan antidiyabetik bir ilaç olan metformin EK tedavisi için güçlü bir aday olarak düşünülmektedir.

Anahtar Kelimeler

• Endometrial kanser,Obezite,İnsülin direnci,Tip 2 Diabetes Mellitus,Metformin

Kaynakça

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