Kanserde Beslenme/Beslenme Metabolizmasının Sirkadiyen Ritim ve DNA Onarımına Etkisi Üzerine Kısa Bir İnceleme

Öz

Sirkadiyen ritim, metabolizma, uyku, nörodavranış, epigenetik ve hormon salgılanması gibi birçok fizyolojik süreci düzenleyen bir saat gibi çalışır, böylece sirkadiyen ritmin bozulması insan sağlığı üzerinde olumsuz etkilere neden olur. DNA'daki mutasyonlar, kanserin (genom hasarının neden olduğu genetik bir hastalık) geliştirme riskini artırır. Kanser oluşumu sirkadiyen ritmin bozulmasından da kaynaklanır. Bu nedenle, bir hücrenin DNA hasarına uygun şekilde yanıt verme ve DNA'yı onarma yeteneği, kanser oluşumunu önlemede kritik öneme sahiptir. DNA hasarının önlenmesi kanserin ortaya çıkması için önemlidir. Epidemiyolojik ve deneysel kanıtlar, kanser prevalansında diyet alımı etkilerinin değişkenliğini açıklamaktadır. Diyet faktörleri, DNA onarımının etkinliğini, epigenetik mekanizmalar üzerindeki etkinliğini ve ayrıca sirkadiyen ritmi etkileyebilir ve kanser oluşumunu engelleyebilir. Bu derlemenin amacı beslenmenin sirkadiyen ritim ve DNA onarımı üzerindeki etkilerini ortaya koymak, mevcut çalışmaların azlığını vurgulamak ve olası deneysel çalışmaların önünü açmaktır. Bu alanda çok az çalışma vardır ve sirkadiyen ritmi etkileyen besinlerle ilgili gelecekte yapılacak çalışmalar kanser tedavisine yeni çözümler bulmak için çok değerlidir. Beslenmenin sirkadiyen sistem ve DNA onarımının için birçok etkisi ve nihayetinde kronik hastalıkların yükünü azaltmada yardımcı rolü olabilir.

Anahtar Kelimeler

• Beslenme
• DNA tamiri
• Kanser
• Sirkadiyen ritim

A Brief Review on The Effect of Nutrition/Nutritional Metabolism on Circadian Rhythm and DNA Repair in Cancer

Öz

The circadian rhythm works as a clock that regulates many physiological processes including metabolism, sleep, neurobehavior, epigenetic and hormone secretion so that disruption of the circadian rhythm causes adverse effects on human health. The mutations in DNA increases the risk of developing cancer (a genetic disease caused by genome damage). Cancer formation is also caused by disruption of the circadian rhythm. Therefore, a cell's ability to properly respond to DNA damage and repair DNA is critical in preventing cancer formation. Prevention of DNA damage is important for the occurrence of cancer. Epidemiological and experimental evidence explain the variation of dietary intake effects in cancer prevalence. Dietary factors may affect the efficiency of DNA repair, their effectiveness on epigenetic mechanisms, as well as circadian rhythm and inhibit cancer formation. The purpose of this review is to reveal the effects of nutrition on circadian rhythm and DNA repair, emphasize the scarcity of existing studies, and pave the way for possible experimental studies. There are very few studies in this field, and the future studies of nutrients that effects circadian rhythm are very valuable in order to find new solutions in cancer treatment. Nutrition may have many effects on the circadian system and DNA repair, and ultimately help reduce the burden of chronic diseases.

Anahtar Kelimeler

• Cancer
• Circadian rhythm
• DNA repair
• Nutrition

Kaynakça

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