DEPRESYONLU BİREYLERDE KURKUMİN KULLANIMI

Yıl 2023, , 8 - 15, 13.10.2023

Kardelen Yoldaş , Müveddet Emel Alphan , Betül Koçak

https://doi.org/10.54270/atljm.2023.37

Öz

Depresyon ruhsal sağlığı etkileyen ve toplum sağlığını tehdit eden sorunlarından biridir. COVİD- 19 ile depresyon vakalarında artış bildirilmektedir. Depresyonlu bireylerin tedavisinde yer alan ilaçlardan bu bireyler yan etkileri (ağız kuruluğu, baş dönmesi, cinsel işlevlerde azalma vb) sebebiyle kullanımından kaçınabilmektedir. Bu durum depresyonlu bireylerin tedavisinde yer alan ilaç ve psikoterapiye ek tedavi araştırmalarına yol açmıştır. Bu ek tedavilerde alternatif tıbbi ürünlerinin kullanımı da son zamanlarda kılavuzlarda yer almaya başlamıştır. Curcuma Longa bitkisinden elde edilen zerdeçalın bir biyoaktif bileşeni olan kurkumin depresyonlu bireylerde farmakolojik tedaviden bağımsız olarak tedavi edici etkilerinin olduğu tartışılmaktadır. Oral yolla alınan zerdeçaldaki kurkumin miktarı ve biyoyararlanımı düşüktür. Kurkuminin etkinliğinde artış sağlayan biyoaktif birleşenler ile tüketimi biyoyararlanımı desteklemektedir. Bu derleme depresyona sahip bireylerde kurkuminin etkilerini inceleyen güncel makalelerden derlenerek depresyonlu bireylerde kurkumin takviyesini incelemektedir.

Anahtar Kelimeler

Kurkumin, Zerdeçal, Curcuma Longa, Depresyon, Besin desteği

Kaynakça

• Delikanlı Akbay, G., & Pekcan, A. G. (2016). Zerdeçal: Beslenme ve sağlık yönünden değerlendirilmesi. Beslenme Ve Diyet Dergisi, 44(1), 68-72.
• Ahmad, R. S., Hussain, M. B., Sultan, M. T., Arshad, M. S., Waheed, M., Shariati, M. A., ... & Hashempur, M. H. (2020). Biochemistry, safety, pharmacological activities, and clinical applications of turmeric: a mechanistic review. Evidence-based complementary and alternative medicine, 2020.
• Ali, Z., Saleem, M., Atta, B. M., Khan, S. S., & Hammad, G. (2019). Determination of curcuminoid content in turmeric using fluorescence spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 213, 192-198.
• Pulido-Moran, M., Moreno-Fernandez, J., Ramirez-Tortosa, C., & Ramirez-Tortosa, M. (2016). Curcumin and health. Molecules, 21(3), 264.
• American Psychiatric Association (APA). ‘’What Is Depression?’’. Access: June 19, 2023. Available at: https://psychiatry.org/patients-families/depression/what-is-depression
• World Health Organization (WHO). ‘’Depression’’. Access: June 19, 2023. Available at: https://www.who.int/news-room/fact-sheets/detail/depression
• Hyland, P., Shevlin, M., McBride, O., Murphy, J., Karatzias, T., Bentall, R. P., ... & Vallières, F. (2020). Anxiety and depression in the Republic of Ireland during the COVID‐19 pandemic. Acta Psychiatrica Scandinavica, 142(3), 249-256.
• Prasad, S., Tyagi, A. K., & Aggarwal, B. B. (2014). Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer research and treatment: official journal of Korean Cancer Association, 46(1), 2.
• Vecchione, R., Quagliariello, V., Calabria, D., Calcagno, V., De Luca, E., Iaffaioli, R. V., & Netti, P. A. (2016). Curcumin bioavailability from oil in water nano-emulsions: In vitro and in vivo study on the dimensional, compositional and interactional dependence. Journal of Controlled Release, 233, 88-100.
• Liu, W., Zhai, Y., Heng, X., Che, F. Y., Chen, W., Sun, D., & Zhai, G. (2016). Oral bioavailability of curcumin: problems and advancements. Journal of drug targeting, 24(8), 694-702.
• Lee, C. H., & Giuliani, F. (2019). The role of inflammation in depression and fatigue. Frontiers in immunology, 1696.
• National Institute of Mental Health. ‘’Chronic Illness and Mental Health: Recognizing and Treating Depression.’’Access: June 25, 2023. Available at: https://www.nimh.nih.gov/health/publications/chronic-illness-mental-health
• Esmaily, H., Sahebkar, A., Iranshahi, M., Ganjali, S., Mohammadi, A., Ferns, G., & GhayourMobarhan, M. (2015). An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chinese journal of integrative medicine, 21(5), 332-338.
• Fusar-Poli, L., Vozza, L., Gabbiadini, A., Vanella, A., Concas, I., Tinacci, S., ... & Aguglia, E. (2020). Curcumin for depression: a meta-analysis. Critical reviews in food science and nutrition, 60(15), 2643-2653.
• Lopresti, A. L. (2022). Potential role of curcumin for the treatment of major depressive disorder. CNS Drugs, 1-19.
• Ramaholimihaso, T., Bouazzaoui, F., & Kaladjian, A. (2020). Curcumin in depression: potential mechanisms of action and current evidence—a narrative review. Frontiers in Psychiatry, 1302.
• Hoffmann, K., Emons, B., Brunnhuber, S., Karaca, S., & Juckel, G. (2019). The Role of Dietary Supplements in Depression and Anxiety - A Narrative Review. Pharmacopsychiatry, 52(6), 261–279.
• Lopresti, A. L., & Drummond, P. D. (2017). Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebocontrolled study. Journal of affective disorders, 207, 188-196.
• Ravindran, A. V., Balneaves, L. G., Faulkner, G., Ortiz, A., McIntosh, D., Morehouse, R. L., ... & CANMAT Depression Work Group. (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 clinical guidelines for the management of adults with major depressive disorder: section 5. Complementary and alternative medicine treatments. The Canadian Journal of Psychiatry, 61(9), 576-587.
• Ashraf, H., Salehi, A., Sousani, M., & Sharifi, M. H. (2021). Use of complementary alternative medicine and the associated factors among patients with depression. Evidence-Based Complementary and Alternative Medicine, 2021.
• Arora, V., Kuhad, A., Tiwari, V., & Chopra, K. (2011). Curcumin ameliorates reserpine-induced pain–depression dyad: Behavioural, biochemical, neurochemical and molecular evidences. Psychoneuroendocrinology, 36(10), 1570-1581.
• Asadi, S., Gholami, M. S., Siassi, F., Qorbani, M., & Sotoudeh, G. (2020). Beneficial effects of nano‐curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: a randomized, double‐blind, placebo‐controlled clinical trial. Phytotherapy Research, 34(4), 896-903.
• Shen, J. D., Wei, Y., Li, Y. J., Qiao, J. Y., & Li, Y. C. (2017). Curcumin reverses the depressivelike behavior and insulin resistance induced by chronic mild stress. Metabolic brain disease, 32(4), 1163-1172.
• European Medicines Agency Science Medicines Health. Committee on Herbal Medicinal Products (HMPC).(25 September 2018). Assessment report on Curcuma longa L., rhizoma final / EMA/HMPC/329745/2017.
• Tarım ve Orman Bakanlığı. Takviye Edici Gıdalar Kısıtlı Maddeler Listesi (Son Güncelleme Tarihi: 22/04/2022) Erişim adresi: https://www.tarimorman.gov.tr/GKGM/Belgeler/DB_Gida_Isletmeleri/Takviye_Edici_Gidala r_Kisitli_Maddeler_Listesi.pdf
• Sanmukhani, J., Satodia, V., Trivedi, J., Patel, T., Tiwari, D., Panchal, B., ... & Tripathi, C. B. (2014). Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytotherapy research, 28(4), 579-585.
• Yu, J. J., Pei, L. B., Zhang, Y., Wen, Z. Y., & Yang, J. L. (2015). Chronic supplementation of curcumin enhances the efficacy of antidepressants in major depressive disorder: a randomized, double-blind, placebo-controlled pilot study. Journal of clinical psychopharmacology, 35(4), 406-410.
• Kuszewski, J. C., Howe, P., & Wong, R. (2020). An exploratory analysis of changes in mental wellbeing following curcumin and fish oil supplementation in middle-aged and older adults. Nutrients, 12(10), 2902.
• Kanchanatawan, B., Tangwongchai, S., Sughondhabhirom, A., Suppapitiporn, S., Hemrunrojn, S., Carvalho, A. F., & Maes, M. (2018). Add-on treatment with curcumin has antidepressive effects in Thai patients with major depression: results of a randomized double-blind placebocontrolled study. Neurotoxicity research, 33(3), 621-633.
• Lopresti, A. L., Maes, M., Maker, G. L., Hood, S. D., & Drummond, P. D. (2014). Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. Journal of affective disorders, 167, 368-375.