ŞİZOFRENİ VE GLUTENSİZ DİYET

Yıl 2023, Cilt: 3 Sayı: 8 - Ekim 2023, 16 - 24, 13.10.2023

Melis Bozoğlu

https://doi.org/10.54270/atljm.2023.38

Öz

Gluten bazı hastalıkların etiyolojisindeki rolü nedeniyle sağlık profesyonelleri için önemli bir araştırma konusudur. Glutenin vücuttaki inflamatuar etkisi gluten ile birçok hastalığın arasındaki ilişkinin incelenmesine neden olmuştur. Gastrointestinal sistem ve merkezi sinir sistemi arasında mevcut olan ilişki sebebiyle, bağırsak geçirgenliğinin bozulduğu durumlarda nöropsikiyatrik hastalıkların ortaya çıkabilme olasılığı son yıllarda gündeme gelmiştir. Patofizyolojisinde glutenin rolü olduğu düşünülen birçok nöropsikiyatrik hastalık bulunmaktadır. Otizm spektrum bozukluğu, epilepsi, iki uçlu bozukluk ve şizofreni bunlardan bazılarıdır. Bunların arasında şizofreni ve gluten ilişkisi 1960’lı yıllardan beri araştırılmaktadır. 2.Dünya Savaşı sırasında buğday tüketiminin azalması ile orantılı şekilde, şizofreni tanısı alan insanların sayısındaki azalma bilim insanlarının dikkatini çekmiştir. Kesin tedavisi olmayan şizofreni hastalığı için alternatif tedavi arayışları bu konuda yapılan araştırmaları yoğunlaştırmıştır. Bu arayış sonunda şizofreni hastalarında glutensiz diyet denenmiştir. Şizofreni hastalarında glutensiz diyet uygulaması konusunda yapılan araştırmalarda çelişkili sonuçlar olmakla birlikte, ortak bir kanıya varılmıştır. Bir kişide şizofreni gelişmesinin risk faktörü eğer gluten maruziyetiyse, glutensiz diyet şizofreninin bazı alt gruplarının ilaçsız tedavisinde yeni bir umut olabilir.

Anahtar Kelimeler

Şizofreni, Gluten, Glutensizdiyet, İmmünoloji

Etik Beyan

Bu çalışmada herhangi bir potansiyel çıkar çatışması ve etik ikilem bulunmamaktadır.

Destekleyen Kurum

İstanbul Atlas Üniversitesi

Proje Numarası

-

Teşekkür

Prof. Dr. H. Şeyda Özcan'a teşekkürler

Kaynakça

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