Cognitive Communication Disorders After COVID-19 In The Pediatric Population

Öz

The Coronavirus Disease-2019 (COVID-19), which emerged in recent years and has affected the whole world, has resulted in millions of people being diagnosed with COVID-19. The symptoms of COVID-19 are quite diverse and can affect various systems in cases. The effects on systems can lead to impaired functioning in different areas. One of the affected areas is cognition. Even if the cases overcome the disease process, the effects of cognitive symptoms that occur with the diagnosis of COVID-19 may continue for a long time, and some symptoms may even be permanent. Attention, concentration and memory are among the most affected cognitive areas. Various effects on cognition can result in cognitive communication disorders. Studies, especially in the adult population, provide evidence of cognitive communication disorders following a diagnosis of COVID-19. The occurrence of cognitive communication disorders in the adult population suggests that the same problems may be seen in the pediatric population. A limited number of studies in the pediatric population have reported effects on cognition and communication following a diagnosis of COVID-19. Healthcare professionals should have knowledge about cognitive communication disorders seen after COVID-19 in the pediatric population, be able to evaluate the disorder and provide the intervention developed for the needs of the case as a result of the evaluations. The limited number of studies on cognitive communication disorders seen after COVID-19 in the pediatric population may reveal difficulties in the diagnosis of COVID-19 and the management of the processes afterwards. In this review study, it is aimed to explain the characteristics of cognitive communication disorders that can be seen after COVID-19 in the pediatric population, screening, diagnosis, evaluation and intervention processes and to address the process in a more appropriate and effective way.

Anahtar Kelimeler

• Assessment
• communication disorders
• intervention
• pediatric
• long-COVID

Pediatrik Popülasyonda COVID-19 Sonrası Görülen Bilişsel İletişim Bozuklukları

Öz

Geçtiğimiz yıllarda ortaya çıkan ve tüm dünyayı etkisi altına alan Koronavirus Hastalığı-2019 (COVID-19), milyonlarca insanın COVID-19 tanısı almasıyla sonuçlanmıştır. COVID-19 semptomları oldukça çeşitlidir ve vakalarda çeşitli sistemlerde etkisini gösterebilmektedir. Sistemlerdeki etkilenimler, farklı alanlardaki işlevlerde bozulmaya yol açabilmektedir. Etkilenen alanlardan bir tanesi de bilişsel alanlardır. Vakalar, hastalık sürecini atlatsalar dahi COVID-19 tanısıyla birlikte ortaya çıkan bilişsel semptomların etkileri uzun süre devam edebilmekte hatta bazı semptomlar kalıcı olabilmektedir. En çok etkilenen bilişsel alanlar arasında dikkat, konsantrasyon ve bellek göze çarpmaktadır. Bilişte görülen çeşitli etkilenimler, bilişsel iletişim bozukluklarıyla sonuçlanabilmektedir. Özellikle yetişkin popülasyonda yapılan çalışmalar, COVID-19 tanısını takiben gelişen bilişsel iletişim bozukluklarına kanıt sunmaktadır. Yetişkin popülasyonda bilişsel iletişim bozukluklarının görülmesi pediatrik popülasyonda da aynı sorunların görülebileceğini akla getirmektedir. Pediatrik popülasyonda yapılan sınırlı sayıda çalışma, COVID-19 tanısı sonrasında bilişte ve iletişimde etkilenimler bildirmiştir. Sağlık personelleri, pediatrik popülasyonda COVID-19 sonrası görülen bilişsel iletişim bozuklukları hakkında bilgi sahibi olmalı, bozukluğu değerlendirebilmeli ve değerlendirmeler sonucunda vakanın gereksinimlere yönelik geliştirilen müdahaleyi sunabilmelidir. Pediatrik popülasyonda COVID-19 sonrası görülen bilişsel iletişim bozukluklarıyla ilgili çalışmaların oldukça sınırlı olması, COVID-19 tanısı ve sonrasındaki süreçlerin yönetiminde zorlukları ortaya çıkarabilmektedir. Bu derleme çalışmasında pediatrik popülasyonda COVID-19 sonrasında görülebilecek bilişsel iletişim bozukluklarının özellikleri, tarama, tanı, değerlendirme ve müdahale süreçlerinin açıklanmasıyla sürecin daha uygun ve etkili bir şekilde ele alınması amaçlanmaktadır.

Anahtar Kelimeler

• Değerlendirme
• iletişim bozuklukları
• müdahale
• pediatrik
• uzamış COVID

Kaynakça

1. American Psychiatric Association". (2023). Children and COVID-19: State-Level Data Report. https://www.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/children-and-covid-19-state-level-data-report/.
2. Baig, A. M., Khaleeq, A., Ali, U., & Syeda, H. (2020). Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host–virus interaction, and proposed neurotropic mechanisms. ACS Chemical Neuroscience, 11(7), 995-998. https://doi.org/10.1021/acschemneuro.0c00122
3. Beaud, V., Crottaz-Herbette, S., Dunet, V., Vaucher, J., Bernard-Valnet, R., Du Pasquier, R., Bart, P.-A., & Clarke, S. (2020). Pattern of cognitive deficits in severe COVID-19. Journal of Neurology, Neurosurgery & Psychiatry, 92(5), 567-568. https://doi.org/10.1136/jnnp-2020-325173
4. Berg, S. K., Nielsen, S. D., Nygaard, U., Bundgaard, H., Palm, P., Rotvig, C., & Christensen, A. V. (2022). Long COVID symptoms in SARS-CoV-2-positive adolescents and matched controls (LongCOVIDKidsDK): a national, cross-sectional study. The lancet child & adolescent health, 6(4), 240-248. https://doi.org/10.1016/s2352-4642(22)00004-9
5. Bloise, S., Isoldi, S., Marcellino, A., De Luca, E., Dilillo, A., Mallardo, S., Martucci, V., Sanseviero, M., Del Giudice, E., & Iorfida, D. (2022). Clinical picture and long-term symptoms of SARS-CoV-2 infection in an Italian pediatric population. Italian Journal of Pediatrics, 48(1), 1-12. https://doi.org/10.1186%2Fs13052-022-01270-1
6. Borch, L., Holm, M., Knudsen, M., Ellermann-Eriksen, S., & Hagstroem, S. (2022). Long COVID symptoms and duration in SARS-CoV-2 positive children—a nationwide cohort study. European Journal of Pediatrics, 181(4), 1597-1607. https://doi.org/10.1007/s00431-021-04345-z
7. Buonsenso, D., Munblit, D., De Rose, C., Sinatti, D., Ricchiuto, A., Carfi, A., & Valentini, P. (2021a). Preliminary evidence on long COVID in children. Acta Paediatrica (Oslo, Norway: 1992), 110(7), 2208. https://doi.org/10.1111/apa.15870
8. Buonsenso, D., Pujol, F. E., Munblit, D., Pata, D., McFarland, S., & Simpson, F. K. (2021b). Clinical characteristics, activity levels and mental health problems in children with long coronavirus disease: A survey of 510 children. Future Microbiology, 17(8), 577-588. https://doi.org/10.2217/fmb-2021-0285

9. Cummings, L. (2021). Cognitive-linguistic difficulties in COVID-19: A longitudinal case study. International Journal of Speech & Language Pathology and Audiology, 9, 8-19. https://doi.org/10.12970%2F2311-1917.2021.09.03
10. Cummings, L. (2023a). Cognitive-communication difficulties in adults with long Covid. In COVID-19 and Speech Language Pathology (pp. 72-95). Taylor & Francis. https://doi.org/10.4324/9781003257318-5
11. Cummings, L. (2023b). Communication-related quality of life in adults with Long COVID. In COVID-19 and Speech Language Pathology (pp. 96-129). Taylor & Francis. https://doi.org/10.4324/9781003257318-6
12. Cummings, L. (2023c). Long COVID: The impact on language and cognition. Language and Health, 2-9. https://doi.org/10.1016/j.laheal.2023.05.001
13. Dawson, C., Clunie, G., Evison, F., Duncan, S., Whitney, J., Houchen-Wolloff, L., Bolton, C. E., Leavy, O. C., Richardson, M., & Omer, E. (2023). Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis. BMJ Open Respiratory Research, 10(1), e001647. https://doi.org/10.1136%2Fbmjresp-2023-001647
14. Gonzalez-Aumatell, A., Bovo, M. V., Carreras-Abad, C., Cuso-Perez, S., Domènech Marsal, È., Coll-Fernández, R., Goicoechea Calvo, A., Giralt-López, M., Enseñat Cantallops, A., & Moron-Lopez, S. (2022). Social, Academic and Health Status Impact of Long COVID on Children and Young People: An Observational, Descriptive, and Longitudinal Cohort Study. Children, 9(11), 1677. https://doi.org/10.3390/children9111677
15. Guido, C. A., Lucidi, F., Midulla, F., Zicari, A. M., Bove, E., Avenoso, F., Amedeo, I., Mancino, E., Nenna, R., & De Castro, G. (2022). Neurological and psychological effects of long COVID in a young population: A cross-sectional study. Frontiers in Neurology, 13, 925144. https://doi.org/10.3389/fneur.2022.925144
16. Hilado, M., Banh, M., Homans, J., & Partikian, A. (2022). Pediatric autoimmune encephalitis following COVID-19 infection. Journal of Child Neurology, 37(4), 268-272. https://doi.org/10.1177/08830738211069814
17. Izquierdo-Pujol, J., Moron-Lopez, S., Dalmau, J., Gonzalez-Aumatell, A., Carreras-Abad, C., Mendez, M., Rodrigo, C., & Martinez-Picado, J. (2022). Post COVID-19 condition in children and adolescents: an emerging problem. Frontiers in pediatrics, 10, 894204. https://doi.org/10.3389/fped.2022.894204
18. King, J. A., Whitten, T. A., Bakal, J. A., & McAlister, F. A. (2021). Symptoms associated with a positive result for a swab for SARS-CoV-2 infection among children in Alberta. CMAJ : Canadian Medical Association Journal = Journal de l'Association Medicale Canadienne, 193(1), E1-E9. https://doi.org/10.1503/cmaj.202065
19. Köse, A., Uysal, H. T., Parlak, M. M., Dumbak, A. B., Tanrıverdi, M., & Kavakcı, M. (2022). The investigation of the cognitive communication functions of survivors of Coronavirus disease 2019 (COVID-19): A survey study. Karya Journal of Health Science, 3(3), 338-342. https://doi.org/10.52831/kjhs.1173174
20. Lopez-Leon, S., Wegman-Ostrosky, T., Ayuzo del Valle, N. C., Perelman, C., Sepulveda, R., Rebolledo, P. A., Cuapio, A., & Villapol, S. (2022). Long-COVID in children and adolescents: A systematic review and meta-analyses. Scientific reports, 12(1), 9950. https://doi.org/10.1038/s41598-022-13495-5
21. Monje, M., & Iwasaki, A. (2022). The neurobiology of long COVID. Neuron, 110(21), 3484-3496. https://doi.org/10.1016%2Fj.neuron.2022.10.006
22. Morand, A., Campion, J.-Y., Lepine, A., Bosdure, E., Luciani, L., Cammilleri, S., Chabrol, B., & Guedj, E. (2022). Similar patterns of [18F]-FDG brain PET hypometabolism in paediatric and adult patients with long COVID: a paediatric case series. European Journal of Nuclear Medicine and Molecular Imaging, 49(3), 913-920. https://doi.org/10.1007/s00259-021-05528-4
23. Morrow, A. K., Ng, R., Vargas, G., Jashar, D. T., Henning, E., Stinson, N., & Malone, L. A. (2021). Postacute/long COVID in pediatrics: development of a multidisciplinary rehabilitation clinic and preliminary case series. American Journal of Physical Medicine & Rehabilitation, 100(12), 1140. https://doi.org/10.1097/phm.0000000000001896
24. Negrini, F., Ferrario, I., Mazziotti, D., Berchicci, M., Bonazzi, M., de Sire, A., Negrini, S., & Zapparoli, L. (2021). Neuropsychological features of severe hospitalized coronavirus disease 2019 patients at clinical stability and clues for postacute rehabilitation. Archives of Physical Medicine and Rehabilitation, 102(1), 155-158. https://doi.org/10.1016/j.apmr.2020.09.376
25. Ng, R., Vargas, G., Jashar, D. T., Morrow, A., & Malone, L. A. (2022). Neurocognitive and psychosocial characteristics of pediatric patients with post-acute/long-COVID: A retrospective clinical case series. Archives of Clinical Neuropsychology, 37(8), 1633-1643. https://doi.org/10.1093%2Farclin%2Facac056
26. Panda, P. K., Sharawat, I. K., Panda, P., Natarajan, V., Bhakat, R., & Dawman, L. (2021). Neurological complications of SARS-CoV-2 infection in children: a systematic review and meta-analysis. Journal of Tropical Pediatrics, 67(3), fmaa070. https://doi.org/10.1093/tropej/fmaa070
27. Parlak, M. M., & Saylam, G. (2023). Investıgation of The Effect of Vaccination Status on Taste And Smell in Individuals With Coronavirus Disease 2019 (COVID-19). KBB-Forum, 22(4), 271-281. https://kbb-forum.net/journal/text.php?lang=en&id=634
28. Ramage, A. E. (2020). Potential for cognitive communication impairment in COVID-19 survivors: a call to action for speech-language pathologists. American Journal of Speech-Language Pathology, 29(4), 1821-1832. https://doi.org/10.1044/2020_ajslp-20-00147
29. Roge, I., Smane, L., Kivite-Urtane, A., Pucuka, Z., Racko, I., Klavina, L., & Pavare, J. (2021). Comparison of persistent symptoms after COVID-19 and other non-SARS-CoV-2 infections in children. Frontiers in Pediatrics, 9, 752385. https://doi.org/10.3389%2Ffped.2021.752385
30. Rollins, C. K., Calderon, J., Wypij, D., Taylor, A. M., Kanjiker, T. S. D., Rohde, J. S., Maiman, M., Zambrano, L. D., Newhams, M. M., & Rodriguez, S. (2023). Neurological and Psychological Sequelae Associated With Multisystem Inflammatory Syndrome in Children. JAMA Network Open, 6(7), e2324369-e2324369. https://doi.org/10.1001/jamanetworkopen.2023.24369
31. Semple, D., Howlett, M. M., Strawbridge, J. D., Breatnach, C. V., & Hayden, J. C. (2022). A systematic review and pooled prevalence of delirium in critically ill children. Critical Care Medicine, 50(2), 317-328. https://doi.org/10.1097/ccm.0000000000005260
32. Stephenson, T., Pereira, S. M. P., Shafran, R., De Stavola, B. L., Rojas, N., McOwat, K., Simmons, R., Zavala, M., O'mahoney, L., & Chalder, T. (2022). Physical and mental health 3 months after SARS-CoV-2 infection (long COVID) among adolescents in England (CLoCk): a national matched cohort study. The Lancet Child & Adolescent Health, 6(4), 230-239. https://doi.org/10.1016/s2352-4642(22)00022-0
33. Twohig, H., Bajpai, R., Corp, N., Faux-Nightingale, A., Mallen, C., Robinson, T., Somayajula, G., van der Windt, D., Welsh, V., & Burton, C. (2023). Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis. MedRxiv, 1-30. https://doi.org/10.1101/2023.04.04.23288110
34. Valderas, C., Méndez, G., Echeverría, A., Suarez, N., Julio, K., & Sandoval, F. (2022). COVID-19 and neurologic manifestations: a synthesis from the child neurologist’s corner. World Journal of Pediatrics, 18(6), 373-382. https://doi.org/10.1007/s12519-022-00550-4
35. Vanderlind, W. M., Rabinovitz, B. B., Miao, I. Y., Oberlin, L. E., Bueno-Castellano, C., Fridman, C., Jaywant, A., & Kanellopoulos, D. (2021). A systematic review of neuropsychological and psychiatric sequalae of COVID-19: implications for treatment. Current opinion in psychiatry, 34(4), 420. https://doi.org/10.1097/yco.0000000000000713
36. World Health Organization (WHO). (2023). A clinical case definition for post covıd-19 condition in children and adolescents by expert consensus. https://www.who.int/publications/i/item/WHO-2019-nCoV-Post-COVID-19-condition-CA-Clinical-case-definition-2023-1
37. World Health Organization (WHO). (2024). WHO COVID-19 dashboard. https://data.who.int/dashboards/covid19/cases?n=c.
38. Wu, Y., Xu, X., Chen, Z., Duan, J., Hashimoto, K., Yang, L., Liu, C., & Yang, C. (2020). Nervous system involvement after infection with COVID-19 and other coronaviruses. Brain, Behavior, and Immunity, 87, 18-22. https://doi.org/10.1016/j.bbi.2020.03.031
39. Zavala, M., Ireland, G., Amin-Chowdhury, Z., Ramsay, M. E., & Ladhani, S. N. (2021). Acute and persistent symptoms in children with PCR-confirmed SARS-CoV-2 infection compared to test-negative children in England: active, prospective, national surveillance. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. https://doi.org/10.1093/cid/ciab991
40. Zheng, Y. B., Zeng, N., Yuan, K., Tian, S.-S., Yang, Y. B., Gao, N., Chen, X., Zhang, A. Y., Kondratiuk, A. L., & Shi, P. P. (2023). Prevalence and risk factor for long COVID in children and adolescents: A meta-analysis and systematic review. Journal of Infection and Public Health. https://doi.org/10.1016/j.jiph.2023.03.005