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Leg Cramps and Restless Leg Syndrome in Pregnancy

Yıl 2024, Cilt: 13 Sayı: 2, 160 - 169, 31.12.2024
https://doi.org/10.46971/ausbid.1498244

Öz

During pregnancy, numerous physiological changes occur in a woman's body. Along with these changes, various complaints may also arise. Leg cramps and restless legs syndrome are common ailments during pregnancy. Leg cramps are characterized by painful muscle contractions that occur involuntarily and suddenly. These cramps, which are more frequently observed at night and become more prevalent during the third trimester of pregnancy, affect approximately 30-50% of pregnant women. Medical history, physical examination, and laboratory screening can help identify various causes of muscle cramps. In addition to non-pharmacological recommendations, pharmacological treatment can also be advised for leg cramps. The use of oral magnesium, calcium, and vitamin D supplements can potentially prevent leg cramps. Restless legs syndrome (RLS), on the other hand, is characterized by a strong, involuntary urge to move the legs, primarily occurring during nighttime sleep or rest. RLS is a sensorimotor disorder, and its prevalence increases during the third trimester, with rates ranging between 15.4% and 61.2% in Türkiye. While non-pharmacological treatments can be beneficial for mild forms of RLS, pharmacological agents such as iron supplements, dopaminergic drugs, opioids, anticonvulsants, benzodiazepines, and estrogen may be used for moderate to severe forms. Midwives and healthcare professionals should be informed about leg cramps and restless legs syndrome that may occur during pregnancy. This review aims to provide information on leg cramps and restless legs syndrome observed during pregnancy and to offer updated knowledge on treatment methods.

Etik Beyan

This is a review article.

Destekleyen Kurum

This research did not receive support from any funding agency/industry.

Proje Numarası

Yok

Teşekkür

-

Kaynakça

  • Allen, R. P., Picchietti, D. L., Auerbach, M., Cho, Y. W., Connor, J. R., Earley, C. J., Garcia-Borreguero, D., Kotagal, S., Manconi, M., Ondo, W., Ulfberg, J., Winkelman, J.W., & International Restless Legs Syndrome Study Group. (2018). Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. Sleep Medicine, 41, 27-44. https://doi.org/10.1016/j.sleep.2017.11.1126
  • American Pregnancy Association, Leg cramps during pregnancy (2023). Available at https://americanpregnancy.org/healthy-pregnancy/pregnancy-health-wellness/leg-cramps-during-pregnancy/
  • Arali, M. (2020). Gebelik öncesi beden kütle indeksinin prenatal bağlanma ve anksiyete düzeyine etkisi (Master's thesis, Sağlık Bilimleri Enstitüsü).
  • Araújo, C. A. L. D., Lorena, S. B. D., Cavalcanti, G. C. D. S., Leão, G. L. D. S.Tenório, G. P., & Alves, J. G. B. (2020). Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial. PLoS One, 15(1), e0227497. https://doi.org/10.1371/journal.pone.0227497
  • Aurora, R. N., Kristo, D. A., Bista, S. R., Rowley, J. A., Zak, R. S., Casey, K. R., Lamm, C. I., Tracy, S. L., & Rosenberg, R. S. (2014). The treatment of restless legs syndrome and periodic limb movement disorder in adults—an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. Sleep, 12(1), 99-121. https://doi.org/10.5665/sleep.1988
  • Çetin, F. C., Demirci, N., Çalık, K. Y., & Akıncı, A. Ç. (2017). Gebelikte olağan fiziksel yakınmalar. Zeynep Kâmil Tıp Bülteni, 48(4), 135-141. https://doi.org/10.16948/zktipb.304443
  • Dostal, M., Weber‐Schoendorfer, C., Sobesky, J., & Schaefer, C. (2013). Pregnancy outcome following use of levodopa, pramipexole, ropinirole, and rotigotine for restless legs syndrome during pregnancy: A case series. European Journal of Neurology, 20(9), 1241-1246. https://doi.org/10.1111/ene.12001
  • Duman, M. K., & Kalyoncu, N. İ. (2018). Psikotrop İlaçlar (Antidepresitler, Lityum, Antipsikotikler, Sedatif-Hipnotikler). Kalyoncu Nİ & Kadıoğlu Duman M, (Editörler). Gebelik ve Emzirme Döneminde Klinik Farmakoloji. 1. Baskı. Ankara: Türkiye Klinikleri; 2018. pp.144-54. https://www.turkiyeklinikleri.com/article/en-psikotrop-ilaclar-antidepresifler-lityum-antipsikotikler-sedatif-hipnotikler-84026.html
  • Filiz, M. B., & Çakır, T. (2015). Güncel tanı kriterleri ile huzursuz bacak sendromu. Turkish Journal of Osteoporosis/Turk Osteoporoz Dergisi, 21(2). https://doi.org/10.4274/tod.71601
  • Garrison, S. R., Korownyk, C. S., Kolber, M. R., Allan, G. M., Musini, V. M., Sekhon, R. K., & Dugré, N. (2020). Magnesium for skeletal muscle cramps. Cochrane Database of Systematic Reviews, 9, CD009402. https://doi.org/10.1002/14651858.CD009402.pub3
  • Gossard, T. R., Trotti, L. M., Videnovic, A., & St Louis, E. K. (2021). Restless legs syndrome: contemporary diagnosis and treatment. NeuroTherapeutics, 18(1), 140–155. https://doi.org/10.1007/s13311-021-01019-4
  • Hachul, H., Baracat, E. C., Soares Jr, J. M., Abi Haidar, M., de Mello, M. T., Tufik, S., & Bittencourt, L. R. A. (2007). Estrogen therapy reduces nocturnal periodic limb movements. Maturitas, 58(3), 319-322. https://doi.org/10.1016/j.maturitas.2007.08.009
  • Hensley, J. G. (2009). Leg cramps and restless legs syndrome during pregnancy. Journal of Midwifery & Womens Health, 54(3), 211-218. https://doi.org/10.1016/j.jmwh.2009.01.003
  • Kaçar, N., & Özcan, H. (2021). Gebelikte uyku problemleri ile baş etme ve ebelik rolü. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 18(2), 847-853. https://doi.org/10.38136/jgon.783541
  • Kaplan, Ö. & Başer, M. (2022). Gebelikte huzursuz bacak sendromuna ilişki Türkiye’de yapılan araştırmaların incelenmesi: Bir içerik analiz çalışması. Sürekli Tıp Eğitimi Dergisi, 31(1), 14-24. https://doi.org/10.17942/sted.884979
  • Kaplan, Ö., Başer, M., & Müderris, I. I., (2020). Huzursuz bacak sendromu olan gebelerde sıcak su uygulamasının etkisi: Randomize kontrollü çalışma. 6. Internatıonal Gevher Nesıbe Health Scıences Conference (pp.5-6).
  • Karli, P. (2018). Evaluation of the relationship between serum 25-hydroxyvitamin D levels and extended period of leg cramps in pregnant women. Medical Science and Discovery, 5(6), 220-223. https://doi.org/10.17546/msd.421384
  • Kaya, İ. G., & Koçak, D. Y. (2023). The effects of restless legs syndrome on sleep and quality of life during pregnancy: a comparative descriptive study. Perinatal Journal, 31(1), 41-49. https://doi.org/10.2399/prn.23.0311008
  • Lettieri, C. J., & Eliasson, A. H. (2009). Pneumatic compression devices are an effective therapy for restless legs syndrome: A prospective, randomized, double-blinded, sham-controlled trial. Chest, 135(1), 74-80. https://doi.org/10.1378/chest.08-1665
  • Liu, J., Song, G., Zhao, G., & Meng, T. (2021). Effect of oral magnesium supplementation for relieving leg cramps during pregnancy: A meta-analysis of randomized controlled trials. Taiwanese Journal of Obstetrics and Gynecology, 60(4),609-614. https://doi.org/10.1016/j.tjog.2021.05.006
  • Luo, L., Zhou, K., Zhang, J., Xu, L., & Yin, W. (2020). Interventions for leg cramps in pregnancy. Cochrane Database of Systematic Reviews, 12, CD010655. https://doi.org/10.1002/14651858.CD010655.pub3
  • Malik, U., Qayyum, A., & Khaliq, S. (2022). Comparison of oral magnesium supplements with placebo for pregnancy-induced leg cramps. Pakistan Journal of Medical & Health Sciences, 16(07), 247-247. https://doi.org/10.53350/pjmhs22167247
  • Mansouri, A., Mirghafourvand, M., Charandabi, S. M. A., & Najafi, M. (2017). The effect of Vitamin D and calcium plus Vitamin D on leg cramps in pregnant women: A randomized controlled trial. Journal of research in medical sciences: the official. Journal of Isfahan University of Medical Sciences, 22(1), 24. https://doi.org/10.4103/1735-1995.200271
  • Miller, T. M., & Layzer, R. B. (2005). Muscle cramps. Muscle & Amp; Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 32(4), 431-442. https://doi.org/10.1002/mus.20341
  • Morrow, J. I., Russell, A., Guthrie, E., Parsons, L., Robertson, I., Waddell, R., Irwin, B., McGivern, R. C., Morrison, P. J., & Craig, J. (2006). Malformation risks of antiepileptic drugs in pregnancy: A prospective study from the UK Epilepsy and Pregnancy Register. Journal of Neurology, Neurosurgery& Psychiatry, 77(2), 193-198. https://doi.org/10.1136/jnnp.2005.079376
  • Nygaard, I. H., Valbø, A., Pethick, S. V., & Bøhmer, T. (2008). Does oral magnesium substitution relieve pregnancy-induced leg cramps?. European Journal of Obstetrics & Gynecology and Reproductive Biology, 141(1), 23-26. https://doi.org/10.1016/j.ejogrb.2008.07.005
  • Picchietti, D. L., Hensley, J. G., Bainbridge, J. L., Lee, K. A., Manconi, M., McGregor, J. A., Silver, R. M., Trenkwalder, C., Wlaters, A. S., & International Restless Legs Syndrome Study Group. (2015). Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Medicine Reviews, 22, 64-77. https://doi.org/10.1016/j.smrv.2014.10.009
  • Ramadan, E. N., Said, S. A., Zahra, N. A., & Zaghloul, M. G. (2019). Lifestyle Intervention for reducing leg cramps among pregnant women. American Journal of Nursing, 7(3), 228-237. https://doi.org/10.12691/ajnr-7-3-1
  • Sebo, P., Cerutti, B., & Haller, D. M. (2014). Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations. Family Practice, 31(1), 7-19. https://doi.org/10.1093/fampra/cmt065
  • Silber, M. H., Buchfuhrer, M. J., Earley, C. J., Koo, B. B., Manconi, M., Winkelman, J. W., ... & Walters, A. S. (2021, July). The management of restless legs syndrome: An updated algorithm. In Mayo Clinic Proceedings, 96(7), 1921-1937. Elsevier. https://doi.org/10.1016/j.mayocp.2020.12.026
  • Sönmez, A., & Aksoy Derya, Y. (2018). Effects of sleep hygiene training given to pregnant women with restless leg syndrome on their sleep quality. Sleep and Breathing, 22(2), 527-535. https://doi.org/10.1007/s11325-018-1619-5
  • Şimşek, H., Karaağaç, Y., Tunçer, E., & Yardımcı, H. (2021). Gebelikte folik asit, B12 vitamini, D vitamini ve iyot destekleri kullanmak gerekli midir? Olası riskler. KSU Medical Journal, 16(3), 439-447. https://doi.org/10.17517/ksutfd.832401
  • Trenkwalder, C., Allen, R., Högl, B., Clemens, S., Patton, S., Schormair, B., & Winkelmann, J. (2018). Comorbidities, treatment, and pathophysiology in restless legs syndrome. The Lancet. Neurology, 17(11), 994–1005. https://doi.org/10.1016/S1474-4422(18)30311-9
  • Trotti, L. M., & Becker, L. A. (2019). Iron for the treatment of restless legs syndrome. Cochrane Database of Systematic Reviews, 1, CD007834. https://doi.org/10.1002/14651858.CD007834.pub3
  • World Health Organization. (2016). WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization. https://www.who.int/publications/i/item/9789241549912
  • Yılmaz, N. H., Çelik, F. N. D., & Akbostancı, M. C. (2017). Huzursuz bacak sendromu tedavisinde kanıta dayalı tıp uygulamaları. Parkinson Hastalığı ve Hareket Bozuklukları Dergisi, 20(1-2), 16-27. https://doi.org/10.5606/phhb.dergisi.2017.05
  • Young, G. (2015). Leg cramps. BMJ Clinical Evidence,05, 1113. https://pmc.ncbi.nlm.nih.gov/articles/PMC4429847/pdf/2015-1113.pdf
  • Yüksel, B., Seven, A., Yıldız, Y., Kucur, S. K., Gözükara, İ., Polat, M., Şencan, H., & Keskin, N. (2015). Gebelikte huzursuz bacak sendromu. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 12(4), 144-146. https://dergipark.org.tr/en/download/article-file/933382
  • Zhou, K., West, H. M., Zhang, J., Xu, L., & Li, W. (2015). Interventions for leg cramps in pregnancy. Cochrane Database of Systematic Reviews, 8, CD010655. https://doi.org/10.1002/14651858.CD010655.pub2

Gebelikte Bacak Krampları ve Huzursuz Bacak Sendromu

Yıl 2024, Cilt: 13 Sayı: 2, 160 - 169, 31.12.2024
https://doi.org/10.46971/ausbid.1498244

Öz

Gebelik dönemi boyunca kadın bedeninde pek çok fizyolojik değişiklik meydana gelmektedir. Bu değişikliklerle beraber yakınmalar da ortaya çıkmaktadır. Bacak krampları ve huzursuz bacak sendromu gebelikte sık görülen rahatsızlıklardandır. Bacak krampları, istemsiz ve ani bir şekilde ortaya çıkan, ağrılı kas kasılması ile karakterizedir. Genellikle gece görülen ve gebeliğin üçüncü trimesterinde daha fazla ortaya çıkan bu kramplar, gebelerin yaklaşık %30-50’sini etkilemektedir. Tıbbi öykü, fizik muayene ve laboratuvar taraması, kas kramplarının çeşitli nedenlerini saptamaya yardımcı olabilir. Bacak kramplarında non farmakolojik önerilerin yanı sıra farmakolojik tedavi de önerilebilir. Oral magnezyum, kalsiyum ve oral D vitamini kullanılarak bacak kramplarını önlemek mümkün olabilir. Huzursuz bacak sendromu ise, çoğunlukla gece uykusu veya dinlenme sırasında bacakları hareket ettirmek için güçlü, istemsiz bir dürtü ile karakterize edilen bir rahatsızlıktır. Huzursuz bacak sendromu, sensorimotor bir bozukluktur Üçüncü trimesterde görülme sıklığı artmakta olup, ülkemizde gebelikte prevalansı %15.4-61.2 arasında değişiklik göstermektedir. Huzursuz bacak sendromunun hafif formlarında non farmakolojik tedaviler yararlı olabilirken, orta ve şiddetli formlarında farmakolojik ajan olarak demir ilaçları, dopaminerjik ilaçlar, opioidler, antikonvülzanlar, benzodiazepinler ve östrojen kullanılabilmektedir. Ebeler ve sağlık profesyonelleri gebelikte meydana gelebilecek bacak krampları ve huzursuz bacak sendromu hakkında fikir sahibi olmalıdır. Bu derlemenin amacı, gebelik sırasında görülen bacak krampları ve huzursuz bacak sendromu hakkında bilgi vermek ve tedavi yöntemleri hakkında güncel bilgi sağlamaktır.

Etik Beyan

Bu bir inceleme makalesidir.

Destekleyen Kurum

Herhangi bir kurum ya da kuruluştan finansal destek alınmamıştır.

Proje Numarası

Yok

Teşekkür

-

Kaynakça

  • Allen, R. P., Picchietti, D. L., Auerbach, M., Cho, Y. W., Connor, J. R., Earley, C. J., Garcia-Borreguero, D., Kotagal, S., Manconi, M., Ondo, W., Ulfberg, J., Winkelman, J.W., & International Restless Legs Syndrome Study Group. (2018). Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. Sleep Medicine, 41, 27-44. https://doi.org/10.1016/j.sleep.2017.11.1126
  • American Pregnancy Association, Leg cramps during pregnancy (2023). Available at https://americanpregnancy.org/healthy-pregnancy/pregnancy-health-wellness/leg-cramps-during-pregnancy/
  • Arali, M. (2020). Gebelik öncesi beden kütle indeksinin prenatal bağlanma ve anksiyete düzeyine etkisi (Master's thesis, Sağlık Bilimleri Enstitüsü).
  • Araújo, C. A. L. D., Lorena, S. B. D., Cavalcanti, G. C. D. S., Leão, G. L. D. S.Tenório, G. P., & Alves, J. G. B. (2020). Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial. PLoS One, 15(1), e0227497. https://doi.org/10.1371/journal.pone.0227497
  • Aurora, R. N., Kristo, D. A., Bista, S. R., Rowley, J. A., Zak, R. S., Casey, K. R., Lamm, C. I., Tracy, S. L., & Rosenberg, R. S. (2014). The treatment of restless legs syndrome and periodic limb movement disorder in adults—an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. Sleep, 12(1), 99-121. https://doi.org/10.5665/sleep.1988
  • Çetin, F. C., Demirci, N., Çalık, K. Y., & Akıncı, A. Ç. (2017). Gebelikte olağan fiziksel yakınmalar. Zeynep Kâmil Tıp Bülteni, 48(4), 135-141. https://doi.org/10.16948/zktipb.304443
  • Dostal, M., Weber‐Schoendorfer, C., Sobesky, J., & Schaefer, C. (2013). Pregnancy outcome following use of levodopa, pramipexole, ropinirole, and rotigotine for restless legs syndrome during pregnancy: A case series. European Journal of Neurology, 20(9), 1241-1246. https://doi.org/10.1111/ene.12001
  • Duman, M. K., & Kalyoncu, N. İ. (2018). Psikotrop İlaçlar (Antidepresitler, Lityum, Antipsikotikler, Sedatif-Hipnotikler). Kalyoncu Nİ & Kadıoğlu Duman M, (Editörler). Gebelik ve Emzirme Döneminde Klinik Farmakoloji. 1. Baskı. Ankara: Türkiye Klinikleri; 2018. pp.144-54. https://www.turkiyeklinikleri.com/article/en-psikotrop-ilaclar-antidepresifler-lityum-antipsikotikler-sedatif-hipnotikler-84026.html
  • Filiz, M. B., & Çakır, T. (2015). Güncel tanı kriterleri ile huzursuz bacak sendromu. Turkish Journal of Osteoporosis/Turk Osteoporoz Dergisi, 21(2). https://doi.org/10.4274/tod.71601
  • Garrison, S. R., Korownyk, C. S., Kolber, M. R., Allan, G. M., Musini, V. M., Sekhon, R. K., & Dugré, N. (2020). Magnesium for skeletal muscle cramps. Cochrane Database of Systematic Reviews, 9, CD009402. https://doi.org/10.1002/14651858.CD009402.pub3
  • Gossard, T. R., Trotti, L. M., Videnovic, A., & St Louis, E. K. (2021). Restless legs syndrome: contemporary diagnosis and treatment. NeuroTherapeutics, 18(1), 140–155. https://doi.org/10.1007/s13311-021-01019-4
  • Hachul, H., Baracat, E. C., Soares Jr, J. M., Abi Haidar, M., de Mello, M. T., Tufik, S., & Bittencourt, L. R. A. (2007). Estrogen therapy reduces nocturnal periodic limb movements. Maturitas, 58(3), 319-322. https://doi.org/10.1016/j.maturitas.2007.08.009
  • Hensley, J. G. (2009). Leg cramps and restless legs syndrome during pregnancy. Journal of Midwifery & Womens Health, 54(3), 211-218. https://doi.org/10.1016/j.jmwh.2009.01.003
  • Kaçar, N., & Özcan, H. (2021). Gebelikte uyku problemleri ile baş etme ve ebelik rolü. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 18(2), 847-853. https://doi.org/10.38136/jgon.783541
  • Kaplan, Ö. & Başer, M. (2022). Gebelikte huzursuz bacak sendromuna ilişki Türkiye’de yapılan araştırmaların incelenmesi: Bir içerik analiz çalışması. Sürekli Tıp Eğitimi Dergisi, 31(1), 14-24. https://doi.org/10.17942/sted.884979
  • Kaplan, Ö., Başer, M., & Müderris, I. I., (2020). Huzursuz bacak sendromu olan gebelerde sıcak su uygulamasının etkisi: Randomize kontrollü çalışma. 6. Internatıonal Gevher Nesıbe Health Scıences Conference (pp.5-6).
  • Karli, P. (2018). Evaluation of the relationship between serum 25-hydroxyvitamin D levels and extended period of leg cramps in pregnant women. Medical Science and Discovery, 5(6), 220-223. https://doi.org/10.17546/msd.421384
  • Kaya, İ. G., & Koçak, D. Y. (2023). The effects of restless legs syndrome on sleep and quality of life during pregnancy: a comparative descriptive study. Perinatal Journal, 31(1), 41-49. https://doi.org/10.2399/prn.23.0311008
  • Lettieri, C. J., & Eliasson, A. H. (2009). Pneumatic compression devices are an effective therapy for restless legs syndrome: A prospective, randomized, double-blinded, sham-controlled trial. Chest, 135(1), 74-80. https://doi.org/10.1378/chest.08-1665
  • Liu, J., Song, G., Zhao, G., & Meng, T. (2021). Effect of oral magnesium supplementation for relieving leg cramps during pregnancy: A meta-analysis of randomized controlled trials. Taiwanese Journal of Obstetrics and Gynecology, 60(4),609-614. https://doi.org/10.1016/j.tjog.2021.05.006
  • Luo, L., Zhou, K., Zhang, J., Xu, L., & Yin, W. (2020). Interventions for leg cramps in pregnancy. Cochrane Database of Systematic Reviews, 12, CD010655. https://doi.org/10.1002/14651858.CD010655.pub3
  • Malik, U., Qayyum, A., & Khaliq, S. (2022). Comparison of oral magnesium supplements with placebo for pregnancy-induced leg cramps. Pakistan Journal of Medical & Health Sciences, 16(07), 247-247. https://doi.org/10.53350/pjmhs22167247
  • Mansouri, A., Mirghafourvand, M., Charandabi, S. M. A., & Najafi, M. (2017). The effect of Vitamin D and calcium plus Vitamin D on leg cramps in pregnant women: A randomized controlled trial. Journal of research in medical sciences: the official. Journal of Isfahan University of Medical Sciences, 22(1), 24. https://doi.org/10.4103/1735-1995.200271
  • Miller, T. M., & Layzer, R. B. (2005). Muscle cramps. Muscle & Amp; Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 32(4), 431-442. https://doi.org/10.1002/mus.20341
  • Morrow, J. I., Russell, A., Guthrie, E., Parsons, L., Robertson, I., Waddell, R., Irwin, B., McGivern, R. C., Morrison, P. J., & Craig, J. (2006). Malformation risks of antiepileptic drugs in pregnancy: A prospective study from the UK Epilepsy and Pregnancy Register. Journal of Neurology, Neurosurgery& Psychiatry, 77(2), 193-198. https://doi.org/10.1136/jnnp.2005.079376
  • Nygaard, I. H., Valbø, A., Pethick, S. V., & Bøhmer, T. (2008). Does oral magnesium substitution relieve pregnancy-induced leg cramps?. European Journal of Obstetrics & Gynecology and Reproductive Biology, 141(1), 23-26. https://doi.org/10.1016/j.ejogrb.2008.07.005
  • Picchietti, D. L., Hensley, J. G., Bainbridge, J. L., Lee, K. A., Manconi, M., McGregor, J. A., Silver, R. M., Trenkwalder, C., Wlaters, A. S., & International Restless Legs Syndrome Study Group. (2015). Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation. Sleep Medicine Reviews, 22, 64-77. https://doi.org/10.1016/j.smrv.2014.10.009
  • Ramadan, E. N., Said, S. A., Zahra, N. A., & Zaghloul, M. G. (2019). Lifestyle Intervention for reducing leg cramps among pregnant women. American Journal of Nursing, 7(3), 228-237. https://doi.org/10.12691/ajnr-7-3-1
  • Sebo, P., Cerutti, B., & Haller, D. M. (2014). Effect of magnesium therapy on nocturnal leg cramps: a systematic review of randomized controlled trials with meta-analysis using simulations. Family Practice, 31(1), 7-19. https://doi.org/10.1093/fampra/cmt065
  • Silber, M. H., Buchfuhrer, M. J., Earley, C. J., Koo, B. B., Manconi, M., Winkelman, J. W., ... & Walters, A. S. (2021, July). The management of restless legs syndrome: An updated algorithm. In Mayo Clinic Proceedings, 96(7), 1921-1937. Elsevier. https://doi.org/10.1016/j.mayocp.2020.12.026
  • Sönmez, A., & Aksoy Derya, Y. (2018). Effects of sleep hygiene training given to pregnant women with restless leg syndrome on their sleep quality. Sleep and Breathing, 22(2), 527-535. https://doi.org/10.1007/s11325-018-1619-5
  • Şimşek, H., Karaağaç, Y., Tunçer, E., & Yardımcı, H. (2021). Gebelikte folik asit, B12 vitamini, D vitamini ve iyot destekleri kullanmak gerekli midir? Olası riskler. KSU Medical Journal, 16(3), 439-447. https://doi.org/10.17517/ksutfd.832401
  • Trenkwalder, C., Allen, R., Högl, B., Clemens, S., Patton, S., Schormair, B., & Winkelmann, J. (2018). Comorbidities, treatment, and pathophysiology in restless legs syndrome. The Lancet. Neurology, 17(11), 994–1005. https://doi.org/10.1016/S1474-4422(18)30311-9
  • Trotti, L. M., & Becker, L. A. (2019). Iron for the treatment of restless legs syndrome. Cochrane Database of Systematic Reviews, 1, CD007834. https://doi.org/10.1002/14651858.CD007834.pub3
  • World Health Organization. (2016). WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization. https://www.who.int/publications/i/item/9789241549912
  • Yılmaz, N. H., Çelik, F. N. D., & Akbostancı, M. C. (2017). Huzursuz bacak sendromu tedavisinde kanıta dayalı tıp uygulamaları. Parkinson Hastalığı ve Hareket Bozuklukları Dergisi, 20(1-2), 16-27. https://doi.org/10.5606/phhb.dergisi.2017.05
  • Young, G. (2015). Leg cramps. BMJ Clinical Evidence,05, 1113. https://pmc.ncbi.nlm.nih.gov/articles/PMC4429847/pdf/2015-1113.pdf
  • Yüksel, B., Seven, A., Yıldız, Y., Kucur, S. K., Gözükara, İ., Polat, M., Şencan, H., & Keskin, N. (2015). Gebelikte huzursuz bacak sendromu. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, 12(4), 144-146. https://dergipark.org.tr/en/download/article-file/933382
  • Zhou, K., West, H. M., Zhang, J., Xu, L., & Li, W. (2015). Interventions for leg cramps in pregnancy. Cochrane Database of Systematic Reviews, 8, CD010655. https://doi.org/10.1002/14651858.CD010655.pub2
Toplam 39 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Hizmetleri ve Sistemleri (Diğer)
Bölüm Derleme Makaleler
Yazarlar

Sevil Günaydın 0000-0003-2539-8783

Hüsniye Dinç Kaya 0000-0002-8461-643X

Ntilmper Bozoglou 0009-0006-7545-4009

Proje Numarası Yok
Yayımlanma Tarihi 31 Aralık 2024
Gönderilme Tarihi 9 Haziran 2024
Kabul Tarihi 26 Aralık 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 13 Sayı: 2

Kaynak Göster

APA Günaydın, S., Dinç Kaya, H., & Bozoglou, N. (2024). Gebelikte Bacak Krampları ve Huzursuz Bacak Sendromu. Ankara Sağlık Bilimleri Dergisi, 13(2), 160-169. https://doi.org/10.46971/ausbid.1498244

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