Eosinophilic Variant of Clear Cell Renal Cell Carcinoma: A Case Report

Yıl 2021, Cilt: 4 Sayı: 1, 66 - 70, 29.01.2021

Serpil Paksoy , Emre Tüzel

Öz

The most common malignant tumor of the kidney are clear cell renal cell carcinomas. Clear cell renal cell carcionma is the most commontype of renal cell carcinomas. It is seen an adults in the sixth and seventh decades and of adults. It is seen 2-3 times more in men than inwomen. Prognosis is worse compared to other species. Since eosinophilic variant clear cell carcinomas are highly aggressive and poorprognosis tumors, it is very important to diagnose them. In this article, we present a 55-yar-old female patient with left kidney tumor withleft flank pain. As a result of histological and immunohistochemical examination, the tumor was diagnosed as eosinophilic variant clear cellcarcinoma.

Anahtar Kelimeler

Clear Cell Renal Cell Carcinoma, Eosinophilic Variant of Clear Cell Renal Cell Carcinoma, Kidney

Eozinofilik Varyant Berrak Hücreli Renal Hücreli Karsinom: Bir Olgu Sunumu

Öz

Böbreğin en sık görülen malign tümörü berrak hücreli renal hücreli karsinomlardır. Berrak hücreli renal hücreli karsinom, renal hücreli karsinomların en sık görülen türüdür. Erişkinlerde altıncı ve yedinci dekadlarda, erkeklerde kadınlara göre 2-3 kat daha fazla görülmektedir. Diğer türlerle karşılaştırıldığında prognozu daha kötüdür. Eozinofilik varyant berrak hücreli karsinomlar ise oldukça agresif ve kötü prognozlu tümörlerdir. Bu yüzden bu tümörlerin tanısını koymak oldukça önemlidir. Bu yazıda sol yan ağrısı şikayeti olan 55 yaşında kadın hastanın böbrek tümörü sunulmaktadır. Yapılan histolojik ve immünhistokimyasal inceleme sonucunda tümör eozinofilik varyant berrak hücreli karsinom tanısı almıştır.

Anahtar Kelimeler

Böbrek, Berrak hücreli renal hücreli karsinom, Eozinofilik varyant berrak hücreli renal hücreli karsinom

Kaynakça

• Amin MB, Crotty TB, Tickoo SK, Farrow GM. (1997). Renaloncocytoma: a reappraisal of morphologic features withclinicopathologic findings in 80 cases. Am J Surg Pathol.21(1):1-12.
• Casuscelli J, Weinhold N, Gundem G, et al. (2017). Genomiclandscape and evolution of metastatic chromophobe renalcell carcinoma (published online June 15, 2017). JCI Insight.2(12). Doi:10.1172/jci.insight.92688
• David G. Bostwick, Liang Cheng.(2008). Urologic SurgicalPathology Second Edition. pp 85-87.
• Geramizadeh B, Ravanshad M, Rahsaz M. (2008). Usefulmarkers for differential diagnosis of oncocytoma,chromophobe renal cell carcinoma and conventional renalcell carcinoma. Indian J Pathol Microbiol. 51:167-71.
• Grignon DJ, Che M. (2004). Clear cell renal cell carcinoma. ClinLab Med. 25:305-16.Hes O, Petersson F, Kuroda N, Hora M, Michal M. (2013). Renalhybrid oncocytic/chromophobe tuomors-a review. HistolHistopathol. 28(10):1257-64.
• Kenneth AI, Rebecca CC. (2019). Eosinophilic KidneyTumors:Old and New. Arch Pathol Lab Med.143:1455-63.
• Kryvenko ON, Roquero L, Gupta NS, Lee MW, Epstein JI. (2013).Low-grade clear cell renal cell carcinoma mimickinghemengioma of the kidney: A series of 4 cases. Arch PatholLab Med. 137:251-4.
• Kumar A. (2016). Finger metastases in renal cell carcinoma: Acase report. Asian J Pharm Clin Res. 9:4-6.
• Kuroda N, Tanaka A, Yamaguchi T, et al. (2013). Chromophoberenal cell carcinoma, oncocytic variant: a proposal of anew variant giving a critical diagnostic pitfall in diagnosingrenal oncocytic tumors. Med Mol Morphol. 46(1):49-55.
• Liu Q, Cornejo KM, Cheng L, et al. (2018). Next-generationsequencing to detect deletion of RB1 and ERBB4 genesin chromophobe renal cell carcinoma: a potential role indistinguishing chromophobe renal cell carcinoma fromrenal oncocytoma. Am J Pathol. 188(4):846-52.
• Minakshi G, Dahiya J, Marwaha RK, Dureja H. (2015). Therapiesin cancer treatment: An overview. Int J Pharm Sci. 7:1-9.Pathologyoutlines.com. Eosinophilic Variant of Clear Cell RenalCell Carcinoma. Bakınız:http://www.pathologyoutlines.com/topic/kidneytumormalignantcelleosinophilic.html.
• Sun T, Zhou AG, Liu Q, et al. (2018). ERBB4 and RB1immunohistochemical stains and fluorescence in situhybridization are helpful in distinguishing chromophoberenal cell carcinoma from oncocytoma (abstract). ModPathol. 31:390.
• Wang HY, Mills SE. (2005). KIT and RCC are useful indistinguishing chromophobe renal cell carcinoma fromthe granular variant of clear cell renal cell carcinoma. AmJ Surg Pathol. 29:640-6.
• Zhou M, Netto GJ, Epstein JI. (2012). Neoplastic diseaseof the kidney. In: Zhou M, Netto GJ, Epstein JI, editors.Uropatholoy. Philadelphia, PA:Elsevier. p. 266-338.