HSP Türleri ve Testisler Üzerinde Etkili Bir Protein Olan HSP70

Yıl 2021, Cilt: 4 Sayı: 3, 208 - 214, 20.08.2021

Emine Sarman , Kanat Gülle , Abdullah Sarman

https://doi.org/10.53493/avrasyasbd.839665

Öz

Organizmalar ve hücreler sürekli olarak uyum sağlamaları gereken çeşitli stres faktörlerine maruz kalırlar. Başlangıçta strese duyarlı proteinler olarak tanımlanan Isı Şok Proteinleri (HSP'ler), protein katlanması, taşınması, olgunlaşması ve bozulması gibi birçok hücresel fonksiyonda yer almaktadır. HSP70’in testisler üzerinde önemli rol oynadığı bilinmekte ve özellikle yaşlanmayla birlikte etkisi artmaktadır. Yaşlanmayla spermatogenez ve steroidogenez büyük ölçüde azalmaktadır. Bunun yanı sıra yüksek sıcaklık, toksik kimyasallara ve patojenlere maruz kalma ya da çeşitli çevresel faktörler erkek üreme sistemi üzerinde olumsuz etkiler meydana getirmektedir. Özellikle oksidatif stres, erkek infertilitesiyle ilişkili ana konulardan biridir. Çeşitli çalışmalar, reaktif oksijen türlerinin (ROS) sperm hareketliliğini azaltarak ve sperm deoksiribo nükleik asit yapısına (DNA), doğrudan zarar vererek infertiliteye neden olduğunu göstermiştir; fakat etiyolojisi ve patogenezi henüz tam olarak anlaşılamamıştır. Bu derlemede, HSP70’in etki mekanizması, oksidatif stresin erkek infertilitesindeki rolü üzerine yapılan çalışmalar özetlenmeye çalışılmıştır.

Anahtar Kelimeler

HSP, İnfertilite, Testis

Destekleyen Kurum

Yok.

Proje Numarası

Yok.

Teşekkür

Yok.

HSP70 and Male Infertility

Öz

Organisms and cells are constantly exposed to various stress factors that need to adapt. Heat Shock Proteins (HSPs), originally defined as stress-sensitive proteins, are involved in many cellular functions, such as protein folding, transport, maturation, and degradation. HSP70 is known to play an important role in the testes and its effect is increasing especially with aging. Spermatogenesis and steroidogenesis are greatly reduced with aging. Also, high temperatures, exposure to toxic chemicals and pathogens, or various environmental factors have adverse effects on the male reproductive system. Oxidative stress, in particular, is one of the main issues associated with male infertility. Several studies have shown that reactive oxygen species (ROS) cause infertility by reducing sperm motility and directly damaging sperm deoxyribonucleic acid (DNA), but the etiology and pathogenesis have not yet been fully understood. this review summarizes the studies on the mechanism of action of HSP70 and the role of oxidative stress in male infertility.

Anahtar Kelimeler

HSP, Infertility, Testes

Proje Numarası

Yok.

Kaynakça

• Cao J, Chen Y, Chen J, Yan H, Li M, Wang J. (2016). Fluoride exposure changed the structure and the expressions of Y chromosome related genes in testes of mice. Chemosphere, 161: 292-299. doi: 10.1016/j.chemosphere.2016.06.106.
• Ciocca DR, Cuello-Carrión FD, Natoli AL, Restall C, Anderson RL. (2012). Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression. Histochem Cell Biol, 137: 187-194. doi: 10.1007/s00418-011-0879-y.
• De Maio A. (1999). Heat shock proteins: facts, thoughts, and dreams. Shock. 11: 1-12. doi: 10.1097/00024382-199901000-00001.
• Guo Y, Ziesch A, Hocke S, Kampmann E, Ochs S, De Toni EN, Göke B, Gallmeier E. (2015). Overexpression of heat shock protein 27 (HSP27) increases gemcitabine sensitivity in pancreatic cancer cells through S-phase arrest and apoptosis. J Cell Mol Med, 19: 340-350. doi: 10.1111/jcmm.12444.
• Haak JL, Buettner GR, Spitz DR, Kregel KC. (2009). Aging augments mitochondrial susceptibility to heat stress. Am J Physiol Regul Integr Comp Physiol, 296: R812-R820. doi: 10.1152/ajpregu.90708.2008.
• Hartl FU. (1996). Molecular chaperones in cellular protein folding. Nature, 381: 571-579. doi: 10.1038/381571a0.
• He Y, Luo M, Yi M, Sheng Y, Cheng Y, Zhou R, Cheng H. (2013). Identification of a testis-enriched heat shock protein and fourteen members of Hsp70 family in the swamp eel. PLoS One, 8: e65269. doi: 10.1371/journal.pone.0065269.
• Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, Krausz C. (2012). European Association of Urology guidelines on Male Infertility: the 2012 update. Eur Urol, 62: 324-232. doi: 10.1016/j.eururo.2012.04.048.
• Kamal MM, Omran OM. (2013). The role of heat shock protein 70 induced by geranylgeranylacetone in carbon tetrachloride-exposed adult rat testes. Pathophysiol Off J Int Soc Pathophysiol, 20: 139-146. doi: 10.1016/j.pathophys.2013.03.003.
• Kampinga HH, Hageman J, Vos MJ, Kubota H, Tanguay RM, Bruford EA, Cheetham ME, Chen B, Hightower LE. (2009). Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones, 14: 105-111. doi: 10.1007/s12192-008-0068-7.
• Kim H-E, Jiang X, Du F, Wang X. (2008). PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1. Mol Cell, 30: 239-247. doi: 10.1016/j.molcel.2008.03.014.
• Kimura M, Itoh N, Takagi S, Sasao T, Takahashi A, Masumori N, Tsukamoto T. (2003). Balance of apoptosis and proliferation of germ cells related to spermatogenesis in aged men. J Androl, 24: 185-191. doi: 10.1002/j.1939-4640.2003.tb02661.x.
• Levine AJ. (1997). p53, the cellular gatekeeper for growth and division. Cell, 88: 323-231. doi: 10.1016/s0092-8674(00)81871-1.
• Li Y, Li J, Cui L, Lai Y, Yao Y, Zhang Y, Pang X, Wang J, Liu X. (2013). Inhibitory effect of atorvastatin on AGE-induced HCAEC apoptosis by upregulating HSF-1 protein. Int J Biol Macromol, 57: 259-264. doi: 10.1016/j.ijbiomac.2013.03.035.
• Macario AJL, Conway de Macario E. (2005). Sick chaperones, cellular stress, and disease. N Engl J Med, 353: 1489-1501. doi: 10.1056/NEJMra050111.
• Meinhardt A, Wilhelm B, Seitz J. (1999). Expression of mitochondrial marker proteins during spermatogenesis. Hum Reprod Update, 5: 108-119. doi: 10.1093/humupd/5.2.108.
• Mobaraki F, Seghatoleslam M, Fazel A, Ebrahimzadeh-Bideskan A. (2018). Effects of MDMA (ecstasy) on apoptosis and heat shock protein (HSP70) expression in adult rat testis. Toxicol Mech Methods, 28: 219-229. doi: 10.1080/15376516.2017.1388461.
• Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. (2007). Trends in oxidative aging theories. Free Radic Biol Med, 43: 477-503. doi: 10.1016/j.freeradbiomed.2007.03.034.
• Ritossa FM. (1964). Experimental activation of specific loci in polytene chromosomes of Drosophila. Exp Cell Res, 35: 601-607. doi: 10.1016/0014-4827(64)90147-8.
• Rogon C, Ulbricht A, Hesse M, Alberti S, Vijayaraj P, Best D, Adams IR, Magin TM, Fleischmann BK, Höhfeld J. (2014). HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Mol Biol Cell, 25: 2260-2271. doi: 10.1091/mbc.E14-02-0742.
• Setyarani M, Zinellu A, Carru C, Zulli A. (2014). High dietary taurine inhibits myocardial apoptosis during an atherogenic diet: association with increased myocardial HSP70 and HSF-1 but not caspase 3. Eur J Nutr, 53: 929-937. doi: 10.1007/s00394-013-0596-5.
• Skulachev VP, Longo VD. (2005). Aging as a mitochondria-mediated atavistic program: can aging be switched off? Ann NY Acad Sci, 1057: 145-164. doi: 10.1196/annals.1356.009.
• Tremellen K. (2008). Oxidative stress and male infertility-a clinical perspective. Hum Reprod Update, 14: 243-258. doi: 10.1093/humupd/dmn004.
• Young JC, Agashe VR, Siegers K, Hartl FU. (2004). Pathways of chaperone-mediated protein folding in the cytosol. Nat Rev Mol Cell Biol, 5: 781-791. doi: 10.1038/nrm1492.