K Vitamini ve Bilişsel Performans: Mini Bir Derleme

Yıl 2024, Cilt: 7 Sayı: 1, 61 - 67, 29.01.2024

Zeynep Bengisu Ejder , Emine Merve Ekici

https://doi.org/10.53493/avrasyasbd.1339322

Öz

K vitamini yağda çözünen bir vitamin olup doğada filokinon (K1), menakinon (K2) ve sentetik analog olarak da menadion (K3) formunda kullanılmaktadır. Genellikle koagülasyon üzerine rolü olduğu bilinen K vitamininin günümüzde kardiyovasküler hastalıklar, osteoporoz, vasküler kalsifikasyon, kanser, diyabet ve glisemik kontrol ile de ilişkisi olduğu bildirilmektedir. Aynı zamanda metabolizmada K vitaminine bağımlı proteinlerin karboksilasyonundan da sorumlu olan vitaminin alınımı son zamanlarda daha çok dikkat çekmektedir. Yapılan çalışmalarda K vitamininin beyinde miyelinizasyonun yoğun olduğu bölgelerde Menakinon-4 (MK-4) formunda bulunduğu saptanmış olan K vitamini eksikliğinin bilişsel performans bozukluğunun patogenezinde rol alabileceği bildirilmiştir. K vitamininin bu etkisini Gas-6 ve protein S gibi moleküller aracılığıyla veya nöronları oksidatif stres hasarına karşı koruyarak gösterdiği düşünülmektedir. Bu derlemede K vitamininin bilişsel performans üzerine etkilerini incelemek amaçlanmaktadır.

Anahtar Kelimeler

Antikoagülan, Bilişsel performans, K vitamini, Metabolizma

Kaynakça

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