Polikistik Over Sendromunda Koenzim Q10 Takviyesi

Yıl 2025, Cilt: 8 Sayı: 1, 75 - 82, 31.01.2025

İrem Nur Şahin , Yasemin Akdevelioğlu

https://doi.org/10.53493/avrasyasbd.1439198

Öz

Polikistik over sendromu; hiperandrojenizm (erkeklik hormonu yüksekliği) ve kronik anovulasyon (yumurtlama eksikliği) ile karakterize olup özellikle doğurganlık çağındaki kadınlarda yaygın olarak görülen, hormonal ve metabolik anomalilere bağlı olarak ortaya çıkan endokrin bir bozukluktur. Prevalansı ülkeler arasında farklılık göstermekle birlikte dünya genelinde giderek artma eğilimindedir. Etiyolojisinin hem çevresel hem de genetik faktörlerden kaynaklandığı düşünülse de halen tam olarak anlaşılamamıştır. Hücresel düzeyde, mitokondriyal disfonksiyon, oksidatif stres ve inflamasyonun PKOS patogenezinde rol oynadığı düşünülmektedir. Bu hastaların tedavisinde beslenme gibi konularda yaşam tarzı değişiklikleri yapılarak semptomların giderilmesi amaçlanmıştır. Bu müdahalelerden biri de hastaların diyet takviyesi olarak bir antioksidan olan koezim Q10 kullanmalarıdır. Koenzim Q10, enerji üretiminde yer alarak oksidasyon döngülerini sürdürmektedir. İnsülin ve adiponektin reseptörlerini etkileyerek hastalarda glisemik kontrolü sağlar. İç motokondriyal membranda bulunmasıyla yumurtalık fonksiyonlarının iyileşmesini de desteklemektedir. Bu derleme nitelikteki makalede Google Scholar, ScienceDirect ve PubMed veri tabanları taranarak PKOS tedavisinde koenzim Q10 takviyesinin etkinliğini ve güvenliğini değerlendirmek amaçlanmıştır.

Anahtar Kelimeler

Polikistik over sendromu, Beslenme yaklaşımları, Beslenme, Koenzim Q10

Coenzyme Q10 Supplementation in Polycystic Ovary Syndrome

Öz

Polycystic ovary syndrome is an endocrine disorder characterized by hyperandrogenism (elevated male hormone levels) and chronic anovulation (lack of ovulation), which is especially common in women of reproductive age and occurs due to hormonal and metabolic abnormalities. Its prevalence varies between countries but tends to be increasing worldwide. Although its etiology is thought to be caused by both environmental and genetic factors, it is still not fully understood. At the cellular level, mitochondrial dysfunction, oxidative stress and inflammation are thought to play a role in the pathogenesis of PCOS. In the treatment of these patients, lifestyle changes in areas such as nutrition are aimed to relieve symptoms. One of these interventions is the use of coenzyme Q10, an antioxidant, as a dietary supplement. Coenzyme Q10 maintains oxidation cycles by taking part in energy production. It affects insulin and adiponectin receptors and provides glycemic control in patients. Its presence in the inner mitochondrial membrane also supports the recovery of ovarian function. In this review article, we aimed to evaluate the efficacy and safety of coenzyme Q10 supplementation in the treatment of PCOS by searching Google Scholar, ScienceDirect and PubMed databases.

Anahtar Kelimeler

Polycystic ovary syndrome, Nutritional approaches, Nutrition, Coenzyme Q10

Kaynakça

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