Psychotic Disorder Due to Methamphetamine Use in a Female Case

Abstract

Methamphetamine is an amphetamine-derived drug that is frequently abused worldwide and has strong addictive effects.Chronic methamphetamine use leads to changes in dopaminergic receptor density after a while.It acts on dopaminergic systems, particularly in the mesolimbic system and striatum, resulting in sensitization and addiction.This change in the dopaminergic system may explain the psychotic symptoms. However, the mechanism of psychosis caused by methamphetamine and sex-specific features have not been fully elucidated. Studies in recent years have shown that methamphetamine and similar stimulants cause an increase in the incidence of schizophrenia and related disorders. Methamphetamine psychosis has a clinical presentation very similar to schizophrenia. Sometimes it is very difficult to distinguish them from each other. In this case report, we discuss a female case who developed psychotic disorder after a single use of methamphetamine.

Keywords

• Metamfetamin
• madde kaynaklı psikozlar
• kadın

Bir Kadın Olguda Metamfetamin Kullanımına Bağlı Gelişen Psikotik Bozukluk

Öz

Metamfetamin, Dünya çapında sıklıkla suistimal edilen ve güçlü bağımlılık yapıcı etkileri olan amfetamin türevi bir maddedir. Kronik metamfetamin kullanımı bir süre sonra dopaminerjik reseptör yoğunluğunda değişikliklere yol açar. Özellikle mezolimbik sistem ve striatumdaki dopaminerjik sistemler üzerinde etkilidir. Duyarlılık ve bağımlılıkla sonuçlanır. Dopaminerjik sistemdeki bu değişiklik psikotik belirtileri açıklayabilir. Bununla birlikte metamfetaminin neden olduğu psikoz mekanizması ve cinsiyete özgü özellikler tam olarak aydınlatılabilmiş değildir. Son yıllarda yapılan çalışmalarda metamfetamin ve benzeri uyarıcıların şizofreni ve ilişkili bozuklukların görülme sıklığında artışa neden olduğu ortaya konulmuştur. Metamfetamin psikozu şizofreni benzeri klinik özelliklere sahiptir. Hatta bazen birbirlerinden ayırt etmek oldukça güçtür. Bu olgu sunumunda tek seferlik ve düşük doz metamfetamin kullanımı sonrası psikotik bozukluk gelişen bir kadın olgu ele alınmıştır.

Anahtar Kelimeler

• metamfetamin
• psikoz
• kadın
• Metamfetamin
• madde kaynaklı psikozlar

Kaynakça

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