Alkol Kullanım Bozukluğu Olan Hastalarda Alkol Yoksunluğuna Bağlı Nöbetlerin Öngörülmesinde Nötrofil-Lenfosit Oranının Rolü

Öz

Amaç: Alkol yoksunluğu nöbetleri, potansiyel olarak hayatı tehdit eden, alkol tüketiminin kesilmesi veya azaltılmasından sonra ortaya çıkabilen tıbbi bir durumdur. Alkol yoksunluğu semptomlarında (AYS) inflamatuvar süreçler önemli rol oynamaktadır. Nötrofil-lenfosit oranı (NLO), klinisyenleri belirli klinik durumlarda olası risklere karşı uyarabilen ve tanıyı destekleyen erişilebilir ve basit bir yöntemdir. Bu çalışmanın amacı, NLO skorlarının AYS olan hastalarda nöbet gelişiminin öngörülmesine katkıda bulunup bulunmayacağını araştırmaktır. Yöntem: Bu çalışma, hastanemiz Alkol ve Madde Bağımlılığı Araştırma, Tedavi ve Eğitim Merkezi (AMATEM) Özel Bakım Ünitesi'nde elektronik sağlık kayıtlarının incelenmesi ile gerçekleştirilmiştir. Alkol yoksunluk nöbeti geçiren otuz hasta (N+) ve nöbet geçirmeyen altmış beş alkol kullanım bozukluğu hastası (N-) çalışmaya dahil edilmiştir. Katılımcıların biyokimyasal, sosyodemografik ve klinik özellikleri ile ilgili veriler toplanmıştır. Bulgular: N+ grubu ve N- grubu yaş, ortalama alkol kullanım süresi ve cinsiyet açısından benzerlik göstermiştir. N+ grubunda N- grubuna göre daha yüksek nötrofil ve daha düşük lenfosit seviyeleri saptandı. NLO, N+ grubunda daha yüksek bulundu. İki grup arasındaki bu fark istatistiksel olarak anlamlıydı. Sonuç: NLO, alkol yoksunluğu nöbetlerini öngörmek için kullanılabilecek düşük maliyetli, yaygın olarak ulaşılabilen bir belirteçtir.

Anahtar Kelimeler

• alkol kullanım bozukluğu
• alkol yoksunluk nöbeti
• nötrofil-lenfosit oranı
• inflamasyon

The Role of Neutrophil-Lymphocyte Ratio in Predicting Alcohol Withdrawal-Induced Seizures in Patients with Alcohol Use Disorder

Öz

Objective: Alcohol withdrawal seizures are a medical condition, potentially life-threatening, that can occur after the cessation or reduction of alcohol consumption. Inflammatory changes play a major role in alcohol withdrawal symptoms (AWS). The neutrophil-lymphocyte ratio (NLR) is an accessible and straightforward method that can alert clinicians to possible risks in certain clinical conditions and support diagnosis. This study aimed to investigate whether NLR scores would contribute to the prediction of seizure development in patients with AWS. Method: This study was conducted through electronic health records at Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatry, Neurology, and Neurosurgery- Specific Care Unit of Research, Treatment and Training Center for Alcohol and Substance Dependence (AMATEM). Thirty patients with alcohol withdrawal seizures (SZ+) and sixty-five alcohol use disorder patients without seizures (SZ-) were enrolled. The participants' biochemical, sociodemographic and clinical data were collected. Results: The SZ+ group and SZ- group showed similarities in terms of age, mean duration of alcohol use and gender. Neutrophil levels were higher and lymphocyte levels were lower in the SZ+ group compared to the SZ- group. NLR found higher in SZ+ group. This difference between the two groups was significant. Conclusion: NLR is a low-cost, widely available marker that can be used to predict alcohol withdrawal seizures.

Anahtar Kelimeler

• alcohol withdrawal seizures
• neutrophil-lymphocyte ratio
• inflammation
• alcohol use disorder

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