Baklofen Yoksunluğu Sergileyen Bir Olgu: Klinik Görüşler ve İlaca Ulaşımın Düzenlenme İhtiyacı

Yıl 2025, Cilt: 26 Sayı: 3, 376 - 380, 30.09.2025

Salim Çağatay Kağızman , Ahmet Alp Karakaşlı

https://doi.org/10.51982/bagimli.1654283

Öz

Madde kullanım bozuklukları (MKB) bireylerin sağlığını ve toplumu önemli ölçüde etkilemekte, baklofen de dahil olmak üzere reçeteli ilaçların kötüye kullanımı yeni bir endişe kaynağı haline gelmektedir. Spastisite ve etiket dışı alkol kullanım bozukluğu (AUD) için kullanılan bir GABA-B reseptör agonisti olan baklofen, aniden kesildiğinde toksisite ve şiddetli yoksunluk riskleri taşır. Bu makalede, baklofeni 1000 mg/gün'e çıkaran, deliryum ve rabdomiyoliz dahil olmak üzere bağımlılık ve yoksunluk semptomlarına yol açan, çoklu madde kullanımı olan 31 yaşında bir erkek olgu sunulmuştur. Tedavi için baklofenin yeniden verilmesi, benzodiazepinler, antipsikotikler ve destekleyici bakım gerekmiştir. Bu vaka, özellikle SUD'li bireylerde baklofen'in kötüye kullanım potansiyelini vurgulamakta ve özellikle reçetesiz olarak kolayca erişilebildiği bölgelerde dikkatli reçeteleme ve düzenleyici kontrol ihtiyacının altını çizmektedir.

Anahtar Kelimeler

Baklofen , yoksunluk , GABA-B

A Case with Baclofen Withdrawal: Clinical Insights and the Need for Regulated Access

Öz

Substance use disorders (SUDs) significantly impact individuals' health and society, with prescription drug misuse, including baclofen, becoming an emerging concern. Baclofen, a GABA-B receptor agonist used for spasticity and off-label alcohol use disorder (AUD), carries risks of toxicity and severe withdrawal upon abrupt discontinuation. We present a case of a 31-year-old male with polysubstance abuse who escalated baclofen to 1000 mg/day, leading to dependence and withdrawal symptoms, including delirium and rhabdomyolysis. Treatment required baclofen reintroduction, benzodiazepines, antipsychotics, and supportive care. This case highlights baclofen’s misuse potential, particularly in individuals with SUDs, and underscores the need for cautious prescribing and regulatory control, especially in regions where it is easily accessible without a prescription.

Anahtar Kelimeler

Baclofen , withdrawal , GABA-B

Etik Beyan

The patient provided written informed consent for the publication of the case report.

Kaynakça

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