The Abuse Potential of Carbamazepine: A Case Report

Abstract

Carbamazepine is used for reduction of aggression associated with psychiatric disorders. Carbamazepine is not widely known or recognized as a drug with abuse or misuse potential. In our literature search we have encountered only one case report about the abuse potential of carbamazepine. Here we report a case of carbamazepine misuse we encountered in Turkey. We speculate that the patient’s usage seems to have started with misuse and proceeded into abuse of the medicine. This case study points at a possibility of misuse and perhaps even a risk of abuse of Carbamazepine.

Keywords

• carbamazepine
• abuse
• dependence

Karbamazepinin Olası Kötüye Kullanımı: Olgu Sunumu

Öz

Karbamazepin psikiyatrik bozukluklardaki agresyonun azaltılmasında kullanılmaktadır. Karbamazepin reçete önerisi dışında kullanımı veya kötüye kullanım potansiyeli olan bir ilaç olarak bilinmemektedir. Geçmiş literatürde karbamazepinin kötüye kullanım potansiyelinden bahseden sadece bir olguya rastladık. Bu yazıda, Türkiye’de karbamazepin kötüye kullanımı olan bir olgu sunulmaktadır. Bu ilacın, önerilen dozun dışına çıkmakla başlayıp kötüye kullanım şeklinde devam edildiği düşünülmektedir. Bu olgu, karbamezapinin reçete önerisi dışında kullanma eğilimi veya kötüye kullanım riski olduğunu göstermektedir.

Anahtar Kelimeler

• karbamazepin
• kötüye kullanım
• bağımlılık

Kaynakça

1. 1. Maremmani I, Pacini M, Lamanna F, et al. Mood stabilizers in the treatment of substance use disorders. CNS Spectr 2010; 15: 95-109.
2. 2- Jones RM, Arlidge J, Gillham R, et al. Efficacy of mood stabilisers in the treatment of impulsive or repetitive aggression: systematic review and meta-analysis. Br J Psychiatry 2011; 198: 93-98.
3. 3- Post RM, Ketter TA, Uhde T, Ballenger JC. Thirty years of clinical experience with carbamazepine in the treatment of bipolar illness: principles and practice. CNS Drugs 2007; 21: 47-71.
4. 4- Hosseini SH, Ahmadi A. Abuse of CBZ for euphoria. Drug Res 2014; 64: 1-2.
5. 5- Cooper RJ. Over-the-counter medicine abuse: a review of the literature. Journal of Substance Use 2013; 18: 82-107.
6. 6- Wazaify M, Shields E, Hughes CM, McElnay JC. Societal perspectives on over-the-counter (OTC) medicines. Family Practice 2005; 22: 170-176.
7. 7- Hughes GF, McElnay JC, Hughes CM, McKenna P. Abuse/misuse of non-prescription drugs. Pharm World Sci 1999; 21: 251-255.
8. 8. Barrons R, Roberts N. The role of carbamazepine and oxcabazepine in alcohol withdrawal syndrome. J Clin Pharm Ther 2009; 35: 153-167.

9. 9- Ketter TA, Post RM, Theodore WH. Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders. Neurology 1999; 53 (Suppl.2): 53-67.
10. 10- Aydın PC, Akyalcin S, Mete L. Antiepileptic drugs in the treatment of anxiety disorders. Current Approaches in Psychiatry 2009; 1: 80-94.
11. 11- Sullivan G, Davis S. Is carbamazepine a potential drug of abuse? J Psychopharmacol 1997; 11: 93-94.
12. 12- Soderstrom J, Murray L, Little M, Daly FFS. Toxicology case of the month: carbamazepine overdose. Emergency Medicine Journal : EMJ 2006; 23: 869-871.
13. 13- Ogu CC, Maxa JL. Drug interactions due to cytochrome P450. BUMC Proceedings 2000; 13: 421-423.
14. 14- Lynch T, Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am Fam Physician 2007; 76: 391-396.
15. 15- Spina E, Pisani F, Perucca E. Clinically significant pharmacokinetic drug interactions with carbamazepine. An update. Clin Pharmacokinet 1996; 31: 198-214.