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PERİODONTAL HASTALIKLARDA GENETİK POLİMORFİZMLERİN ROLÜ

Yıl 2012, Cilt: 1 Sayı: 3, 154 - 163, 31.12.2012

Öz


Periodontoloji disiplini, periodontal hastalık patogenezine olan bakış açısını salt mikrobiyal dental plak esaslı ekseninden çıkarmış, enfeksiyon ile konak yanıtı arasındaki çok değişkenli ve karmaşık etkileşim biçiminde geliştirmiştir. Periodontal hastalık patogenezine ait bilinmeyenleri cevaplayabilmek için konak immün yanıtı ile periodontopatik bakteriler arasındaki etkileşimin dinamiklerini bilmek ve bu karmaşık süreçte rol aldığı düşünülen diğer etkenleri analiz etmek gereklidir. Her ne kadar bakteriyel plak varlığı periodontitisin başlaması için gerekli ise de, plak miktarının hastalık şiddeti ile mutlaka korelasyon göstermediği ve bireysel faktörlerin klinik tabloda belirleyici olduğu bilinmektedir. Periodontal hastalığın çağdaş tanımında bakteriyel etiyolojiden çok, konak yanıtı vurgulanmaktadır. Literatürdeki pek çok çalışma ile konak immün yanıtındaki bireyler arası değişkenlik ve pek çok patolojideki genetik bileşen varlığı ortaya konmuştur. İmmün hücre gelişiminde, antijen hücre sunumunda veya non-spesifik immün yanıtta rol alan inflamatuvar medyatörlerdeki genetik varyasyonlar, periodontitis de dahil olmak üzere belli durumlar için risk faktörü olabilir. Bu açıdan bakıldığında periodontitis, fenotipi etkilenen bireydeki genetik yapı ve çevresel etkenler ile şekillenen karmaşık bir genetik hastalık olarak dikkate alınabilir. Dolayısı ile periodontitis ile ilişkili genetik duyarlılık profilinin haritasının çıkarılmasının, tanı yöntemleri ve bireysel tedavi stratejileri geliştirmek açısından getiri sağlayacağı öngörülebilir. Bu sistematik olmayan derlemenin amacı, periodontal hastalıklarda genetik polimorfizmlerin olası rolünün altını çizmek ve ilişkilendirme çalışmalarındaki yöntemler ile ilgili tartışmaları gözden geçirmekti.

Kaynakça

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THE ROLE OF GENETIC POLYMORPHISMS IN PERIODONTAL DISEASES

Yıl 2012, Cilt: 1 Sayı: 3, 154 - 163, 31.12.2012

Öz


Discipline of periodontology shifted the understanding of periodontal disease pathogenesis from solely microbial dental plaque based axis to complex, multi-variate interplay between infection and host response. It is essential to initialize the dynamics of the interaction between the host immune response and periodontopathic bacteria, and to analyse other factors possibly playing role in this complex process. Where the existence of bacterial plaque is a pre-requirement for the initiation of periodontitis, it is well known that amount of plaque does not necessarily correlate with disease severity and individual factors are determinative on clinical presentation. Rather than bacterial aetiology, host response in more emphasized in modern definition of periodontal disease. A sum of researches in the literature has revealed the inter-individual variability regarding host immune response and influence of genetic components in numerous pathologic conditions. Genetic variations in immune cell development, antigen cell presentation or inflammatory mediators of non-spesific immune response could be the risk factors for certain conditions, including periodontitis. From this point of view, periodontitis could be considered as a complex genetic disease with a phenotype configured through the genetic make-up and environmental factors in the affected individual. Therefore, it could be foreseen that mapping of the genetic suspectibility profile related with periodontitis might be very valuable for developing diagnostic techniques and individual treatment strategies. The aim of this non-systematic review was to underline the possible role of genetic polymorphisms in periodontal diseases and to revise the discussions on the methods for association studies.


Kaynakça

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  • 2. Kinane DF, Shiba H, Hart TC. The genetic basis of periodontitis. Periodontol 2000. 2005;39:91-117.
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  • 5. Corey LA, Nance WE, Hofstede P, Schenkein HA. Self-reported periodontal disease in a Virginia twin population. J Periodontol. 1993;64(12):1205-8.
  • 6. Boughman JA, Astemborski JA, Suzuki JB. Phenotypic assessment of early onset periodontitis in sibships. J Clin Periodontol. 1992;19(4):233-9.
  • 7. Marazita ML, Burmeister JA, Gunsolley JC, Koertge TE, Lake K, Schenkein HA. Evidence for autosomal dominant inheritance and race-specific heterogeneity in early-onset periodontitis. J Periodontol. 1994;65(6):623-30.
  • 8. Li Y, Xu L, Hasturk H, Kantarci A, DePalma SR, Van Dyke TE. Localized aggressive periodontitis is linked to human chromosome 1q25. Hum Genet. 2004;114(3):291-7.
  • 9. Laine ML, Loos BG, Crielaard W. Gene polymorphisms in chronic periodontitis. Int J Dent. 2010;2010:324719.
  • 10. Kornman KS, Crane A, Wang HY et al:. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol. 1997;24(1):72-7.
  • 11. Diehl SR, Wang Y, Brooks CN et al:. Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis. J Periodontol. 1999;70(4):418-30.
  • 12. Ishihara Y, Nishihara T, Kuroyanagi T et al:. Gingival crevicular interleukin-1 and interleukin-1 receptor antagonist levels in periodontally healthy and diseased sites. J Periodontal Res. 1997;32(6):524-9.
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Toplam 101 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derlemeler
Yazarlar

Burak Doğan, Bu kişi benim

Gizem Torumtay Bu kişi benim

Yener Özat

Yayımlanma Tarihi 31 Aralık 2012
Gönderilme Tarihi 11 Haziran 2012
Yayımlandığı Sayı Yıl 2012 Cilt: 1 Sayı: 3

Kaynak Göster

APA Doğan, B., Torumtay, G., & Özat, Y. (2012). PERİODONTAL HASTALIKLARDA GENETİK POLİMORFİZMLERİN ROLÜ. Balıkesir Sağlık Bilimleri Dergisi, 1(3), 154-163.

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