BİR ANTİOKSİDAN OLARAK E VİTAMİNİ

Yıl 2017, Cilt: 6 Sayı: 3, 149 - 157, 31.12.2017

Ayşen Altıner Hasan Atalay , Tanay Bilal

Öz

Lipit peroksidasyonu bağışıklığı, büyümeyi ve üremeyi de içeren fizyolojik fonksiyonların bozulmasına yol açar. Bazı antioksidan enzimler, E ve C vitamini gibi eksojen vitaminler ile bazı mineraller, hücreleri lipit peroksidasyonuna karşı korurlar. E vitamininin moleküler ve hücresel etkileri, antioksidan olarak reaktif oksijen türlerini ve nitrik oksiti temizlemek yanında spesifik enzimler ve transkripsiyon faktörleriyle de etkileşerek zarlar ve lipit alanları gibi hücresel yapıları korumaktır. E vitamini, hücre zarlarında bulunan uzun zincirli çoklu doymamış yağ asitlerinin bütünlüğünü korur ve biyoaktivitelerini devam ettirir. E vitamini aynı zamanda, steroid hormon üreten dokularda yoğun olarak bulunur ve bu dokularda sitokrom p-450’nin oldukça duyarlı steroidojenik aktivitelerini lipit peroksidasyonuna karşı korur. Stres, hastalıklar ve immun yanıtın teşviki, vitamin ve esansiyel elementler gibi besin maddelerine olan gereksinimleri arttırabilir. Besinsel dengesizlikler, sıcak, soğuk, kalabalık, gürültü ve taşınma gibi stres unsurları, vücudun savunma mekanizmalarını zayıflatarak enfeksiyöz hastalıklara yatkınlığa neden olabilirler. Stres durumlarında vitamin ve minerallere olan gereksinim artar. Hücre zarına bağlı olan E vitamini, immun yanıtları tetikleyen ve düzenleyen kompleks hücre-hücre etkileşimlerinde önemli bir rol oynar. Karaciğer ve serumdaki E vitamini düzeyleri, E vitamini alımı veya vücuttaki durumunun güvenilir göstergeleridir. Bu derlemenin amacı, E vitamininin antioksidan özellikleri ile ilgili bilgileri ve çalışmaları bir araya getirmektir.

Anahtar Kelimeler

Lipit peroksidasyonu, antioksidan, E vitamini, stres.

VITAMIN E AS AN ANTIOXIDANT

Öz

Lipid peroxidation leads to deterioration of physiological functions including growth and reproduction as well as the immunity. Some antioxidant enzymes and the exogenous vitamins such as vitamin C and E, and some minerals protect cells against lipid peroxidation. Molecular and cellular effects of vitamin E as an antioxidant are to clean the reactive oxygen species and nitric oxide synthase and to influence cellular structures such as membranes and lipid domains by interacting with specific enzymes and transcription factors. Vitamin E maintains integrity of the long chain polyunsaturated fatty acids that are present in the cell membranes, and retains their bioactivity. Vitamin E is also intensely present in tissues producing the steroid hormone, and protects the very sensitive steroidogenic activities of cytochrome P-450 against lipid peroxidation in these tissues. Stress, disease and the promotion of the immune response may increase the need for nutrients such as vitamins and essential elements. Stress factors such as nutritional imbalances, hot and cold, crowds, noise and transport cause a susceptibility to infectious diseases by weakening the body's defense mechanisms. The need for these vitamins and minerals increases in stress situations. Vitamin E depending on the cell membrane plays an important role in complex cell-cell interactions triggering and regulating the immune responses. Liver and serum are reliable indicators of the vitamin E intake or status. The purpose of this review was to bring together the information and works about the antioxidant properties of vitamin E.

Anahtar Kelimeler

Lipid peroxidation, antioxidant, vitamin E

Kaynakça

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