Stresli Yasam Olaylarının Meme Kanseri Gelişimdeki Rolü

Öz

GİRİŞ ve AMAÇ: Son bir yıl içerisinde yaşanılan stresli yaşam olayları ile meme kanseri arasındaki ilişkiyi araştırmak. YÖNTEM ve GEREÇLER: Ölçümler Sarason tarafından geliştirilen Yaşam Deneyimleri Ölçeği ile gerçekleştirildi. Olumsuz olarak algılanan yaşam olaylarının puanlarının toplamı negatif yaşam deneyimleri skoru(NegLES), olumlu olarak bildirilen ise pozitif yaşam deneyimleri skoru(PosLES) olarak ayrı ayrı hesaplandı. Toplanması ile de toplam yaşam deneyimleri puanı(TotLES) elde edildi. BULGULAR: Bu çalışmaya, 139 meme kanseri hastası ile birlikte 139 meme fibrokistik hastalık tanısı olan toplamda 278 gönüllü dahil edildi. Tüm katılımcıların medyan yaşı 48’di (min: 21 maks: 75). Kanser grubunun medyan yaşı 49(min: 26-maks: 75) ve fibrokistik grup ise medyan yaşı 48(min: 21 maks: 71) olarak saptandı(p=0.118). NegLES kanser hastalarında ortalama -7.0±6.5, fobrikist hastalarında ortalama 4.6±5.7 ve TotLES kanser hastalarında ortalama -5.9±6.6, fibrokistik hastalarında ortalama -3.5±6.3 olarak saptandı (her ikisi için, p=0.001). PosLES her iki grup için benzerdi (p=0.697). Kontrol grubuna göre kanser olanlar logistik regresyon ile değerlendirildi. Buna göre NegLES azalması (OR: 0.938 95% CI 0.900-0.977, p=0.002) ve TotLES azalması (OR: 0.942 95% CI 0.906-0.979, p=0.002) meme kanseri riskini azaltıyordu. PosLES meme kanseri gelişimini tahmin etmiyordu (OR: 0.988 95% CI 0.891-1.095, p=0.813). TARTIŞMA ve SONUÇ: Bu çalışma ile, kadınların son bir yıl içerisinde yaşadıkları olumsuz yaşam olaylarının, meme kanseri gelişimine katkı sağladığı sonucuna ulaşıldı.

Anahtar Kelimeler

• Meme kanseri
• Sarason
• Stresli yaşam olayları

The Role of Stressful Life Events in Breast Cancer Etiology

Öz

INTRODUCTION: This study aimed to investigate the relationship between stressful life events experienced in the last year and breast cancer. METHODS: Measurements were made with the Life Experiences Survey developed by Sarason. The sum of the scores perceived as negative was calculated separately as the negative life experiences score (NegLES), and the sum of the scores reported as positive was calculated separately as the positive life experiences score (PosLES). The sum of the two scores was evaluated as the total life experience score (TotLES). RESULTS: A total of 278 participants, 139 patients with breast cancer and 139 diagnosed with breast fibrocystic disease (control), were included in this study. The median age of all participants was 48 (range:21-75). The median age of the cancer group was 49 years (range: 26-75) and the median age of the control group was 48 years (range 21-71)(p=0.118). The mean of NegLES was -7.0±6.5 in cancer patients and 4.6±5.7 in control group and the mean TotLES was -5.9±6.6 in cancer patients and -3.5±6.3 in control group (for both, p=0.001). PosLES was similar for both groups (p=0.697). Compared to the control group, absolute low NegLES (OR: 0.938 95% CI 0.900-0.977, p=0.002) and absolute low TotLES (OR: 0.942 95% CI 0.906-0.979, p=0.002) were associated with decreased breast cancer. PosLES did not predict breast cancer (OR: 0.988 95% CI 0.891-1.095, p=0.813). DISCUSSION AND CONCLUSION: It was concluded that the negative life events experienced by women in the last year contributed to the risk of breast cancer.

Anahtar Kelimeler

• Breast cancer
• Sarason
• Stressful Life Events

Kaynakça

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