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Hypericum perforatum'un Antioksidan Aktivitesinin Belirlenmesi

Yıl 2019, Cilt: 1 Sayı: 1, 9 - 18, 31.12.2019

Öz

Hypericum perforatum antik çağlardan beri
bazı hastalıkları tedavi etmek için hekimler tarafından kullanılmıştır.
Günümüzde insanların doğal tedavilere yönelmesi açısından fitoterapi önemli bir
yere sahiptir. Farmakolojik önem taşıyan ve geleneksel ilaç olarak kullanılan
H. perforatum bitkisinin biyoaktivitelerinin incelenmesi önem
arz etmektedir. H. perforatum bitkisi
Adıyaman Çelikhan bölgesinde dağlık alanda hasat edilmiştir. Bu bitki
ekstraksiyon işlemine tabi tutulup, elde edilen ekraktın antioksidan
kapasiteleri incelenmiştir.
H. perforatum bitkisi DPPH serbest
radikal giderme aktivitesi ve FRAP indirgeme gücü aktivitesi açısından
değerlendirildiğinde önemli bir aktiviteye sahip olduğu görülmüştür.

Kaynakça

  • Akkuş, İ. (1995). Serbest radikaller ve fizyopatolojik etkileri. Mimoza Yayınları, Konya, 1.
  • Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of Agricultural and Food Chemistry, 52(26), 7970–7981.
  • Başköse, İ., & Savran, A. (2018). A new species from southern anatolia (Dedegöl mountain series—Çürük mountain) in Turkey: Hypericum bilgehan-bilgilii (hypericaceae). Phytotaxa, 374(2), 110–118. https://doi.org/10.11646/phytotaxa.374.2.2
  • Baytop, T. (1999). Türkiye’de bitkiler ile tedavi: geçmişte ve bugün. Nobel Tıp Kitabevleri.
  • Blois, M. S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199–1200. https://doi.org/10.1038/1811199a0
  • Briskin, D. P. (2000). Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiology, 124(2), 507–514.
  • Bursal, E., Köksal, E., Gülçin, İ., Bilsel, G., & Gören, A. C. (2013). Antioxidant activity and polyphenol content of cherry stem (Cerasus avium L.) determined by LC–MS/MS. Food Research International, 51(1), 66–74.
  • Butterweck, V, Wall, A., Liefländer-Wulf, U., Winterhoff, H., & Nahrstedt, A. (1997). Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry, 30(S 2), 117–124.
  • Butterweck, Veronika, Petereit, F., Winterhoff, H., & Nahrstedt, A. (1998). Solubilized Hypericin and Pseudohypericin from Hypericum perforatum Exert Antidepressant Activity in the Forced Swimming Test3. Planta Medica, 64(04), 291–294.
  • Chrea, B., O’Connell, J. A., Silkstone-Carter, O., O’Brien, J., & Walsh, J. J. (2014). Nature’s antidepressant for mild to moderate depression: isolation and spectral characterization of hyperforin from a standardized extract of St. John’s wort (Hypericum perforatum). Journal of Chemical Education, 91(3), 440–442.
  • Cracchiolo, C. (1998). Pharmacology of St. John’s Wort: Botanical and Chemical Aspects. Sci Rev Alt Med, 2, 29–35.
  • Curtis, J. D., & Lersten, N. R. (1990). Internal secretory structures in Hypericum (Clusiaceae): H. perforatum L. and H. balearicum L. New Phytologist, 114(4), 571–580.
  • Di Carlo, G., Borrelli, F., Ernst, E., & Izzo, A. A. (2001). St John’s wort: Prozac from the plant kingdom. Trends in Pharmacological Sciences, 22(6), 292–297.
  • Duke, J. A. (1990). CRC Handbook of Medicinal Herbs. In International Clinical Psychopharmacology. https://doi.org/10.1097/00004850-199001000-00014
  • Elmastaş, M., Gülçin, I., Beydemir, Ş., Küfrevioǧlu, Ö. I., & Aboul-Enein, H. Y. (2006). A study on the in vitro antioxidant activity of juniper (Juniperus communis L.) fruit extracts. Analytical Letters, 39, 47–65. https://doi.org/10.1080/00032710500423385
  • Greeson, J. M., Sanford, B., & Monti, D. A. (2001). St. John’s wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology, 153(4), 402–414.
  • Halliwell, B., & Cross, C. E. (1994). Oxygen-derived species: Their relation to human disease and environmental stress. Environmental Health Perspectives, 102(10), 5–12. https://doi.org/10.2307/3432205
  • Halliwell, B., & Gutteridge, J. M. C. (1984). Oxygen toxicity, oxygen radicals, transition metals and disease. Biochemical Journal, 219, 1–14. https://doi.org/10.1042/bj2190001
  • Halliwell, Barry. (1994). Free radicals and antioxidants: a personal view. Nutrition Reviews, 52(8), 253–265.
  • Halliwell, Barry. (1996). Antioxidants in human health and disease. Annual Review of Nutrition, 16(1), 33–50.
  • Herold, A., Cremer, L., Calugăru, A., Tamaş, V., Ionescu, F., Manea, S., & Szegli, G. (2003). Antioxidant properties of some hydroalcoholic plant extracts with antiinflammatory activity. Roumanian Archives of Microbiology and Immunology, 62(3–4), 217–227.
  • Hışıl, Y., Şahin, F., & Omay, S. B. (2005). Kantaronun (Hypericum perforatum L.) bileşimi ve tıbbi önemi. International Journal of Hematology and Oncology, 15, 212–218.
  • Holtom, J. A., & Hylton, W. H. (1979). The Complete Guide to Herbs: How to Grow and Use Nature’s Miracle Plants. Rodale Press. Klemow, K. M., Bartlow, A., Crawford, J., Kocher, N., Shah, J., & Ritsick, M. (2011). 11 Medical Attributes of St. John’s Wort (Hypericum perforatum). Lester Packer, Ph. D., 211–238.
  • Medina, M. A., Martínez-Poveda, B., Amores-Sánchez, M. I., & Quesada, A. R. (2006). Hyperforin: more than an antidepressant bioactive compound? Life Sciences, 79(2), 105–111.
  • Meir, S., Kanner, J., Akiri, B., & Philosoph-Hadas, S. (1995). Determination and involvement of aqueous reducing compounds in oxidative defense systems of various senescing leaves. Journal of Agricultural and Food Chemistry, 43(7), 1813–1819.
  • Miller, A. L. (1998). St. John’s wort (Hypericum perforatum): clinical effects on depression and other conditions. Alternative Medicine Review: A Journal of Clinical Therapeutic, 3(1), 18–26.
  • Nahrstedt, A., & Butterweck, V. (1997). Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry, 30(S 2), 129–134.
  • Oyaizu, M. (1986). Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine. The Japanese Journal of Nutrition and Dietetics, 44(6), 307–315. https://doi.org/10.5264/eiyogakuzashi.44.307
  • Patocka, J. (2003). The chemistry, pharmacology, and toxicology of the biologically active constituents of the herb Hypericum perforatum L. Journal of Applied Biomedicine, 1(2), 61–70.
  • Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., & Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine, 26(9), 1231–1237. https://doi.org/10.1016/S0891-5849(98)00315
  • Redvers, A., Laugharne, R., Kanagaratnam, G., & Srinivasan, G. (2001). How many patients self-medicate with St John’s wort? Psychiatric Bulletin, 25(7), 254–256.
  • Schempp, C. M., Kirkin, V., Simon-Haarhaus, B., Kersten, A., Kiss, J., Termeer, C. C., … Sleeman, J. P. (2002). Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John’s wort that acts by induction of apoptosis. Oncogene, 21(8), 1242.
  • Sen, C., Packer, L., & Hänninen, O. (2000). Handbook of oxidants and antioxidants in exercise. Elsevier.
  • Soare, J. R., Dinis, T. C. P., Cunha, A. P., & Almeida, L. (1997). Antioxidant activities of some extracts of Thymus zygis. Free Radical Research, 26(5), 469–478.
  • Tümen, G., & Sekendiz, O. (1989). Plants used in traditional medicine in Balıkesir and central villages. Uludağ University Research Funding, Project, (86/12), 19–22.

Determination of Antioxidant activity of Hypericum perforatum

Yıl 2019, Cilt: 1 Sayı: 1, 9 - 18, 31.12.2019

Öz

Hypericum perforatum has been used by
physicians since ancient times to treat certain diseases. Nowadays,
phytotherapy has an important place for people to turn to natural treatments.
It is significant to examine the bioactivity of H. perforatum which is of pharmacological importance and used as a
traditional medicine. H. perforatum
plant was harvested in mountainous area in Celikhan region of Adiyaman. This
plant was subjected to extraction process and the antioxidant capacity of the
obtained extract was examined. H.
Perforatum
was found to have remarkable activity when evaluated for DPPH
free radical scavenging activity and FRAP reducing power activity.

Kaynakça

  • Akkuş, İ. (1995). Serbest radikaller ve fizyopatolojik etkileri. Mimoza Yayınları, Konya, 1.
  • Apak, R., Güçlü, K., Özyürek, M., & Karademir, S. E. (2004). Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. Journal of Agricultural and Food Chemistry, 52(26), 7970–7981.
  • Başköse, İ., & Savran, A. (2018). A new species from southern anatolia (Dedegöl mountain series—Çürük mountain) in Turkey: Hypericum bilgehan-bilgilii (hypericaceae). Phytotaxa, 374(2), 110–118. https://doi.org/10.11646/phytotaxa.374.2.2
  • Baytop, T. (1999). Türkiye’de bitkiler ile tedavi: geçmişte ve bugün. Nobel Tıp Kitabevleri.
  • Blois, M. S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199–1200. https://doi.org/10.1038/1811199a0
  • Briskin, D. P. (2000). Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiology, 124(2), 507–514.
  • Bursal, E., Köksal, E., Gülçin, İ., Bilsel, G., & Gören, A. C. (2013). Antioxidant activity and polyphenol content of cherry stem (Cerasus avium L.) determined by LC–MS/MS. Food Research International, 51(1), 66–74.
  • Butterweck, V, Wall, A., Liefländer-Wulf, U., Winterhoff, H., & Nahrstedt, A. (1997). Effects of the total extract and fractions of Hypericum perforatum in animal assays for antidepressant activity. Pharmacopsychiatry, 30(S 2), 117–124.
  • Butterweck, Veronika, Petereit, F., Winterhoff, H., & Nahrstedt, A. (1998). Solubilized Hypericin and Pseudohypericin from Hypericum perforatum Exert Antidepressant Activity in the Forced Swimming Test3. Planta Medica, 64(04), 291–294.
  • Chrea, B., O’Connell, J. A., Silkstone-Carter, O., O’Brien, J., & Walsh, J. J. (2014). Nature’s antidepressant for mild to moderate depression: isolation and spectral characterization of hyperforin from a standardized extract of St. John’s wort (Hypericum perforatum). Journal of Chemical Education, 91(3), 440–442.
  • Cracchiolo, C. (1998). Pharmacology of St. John’s Wort: Botanical and Chemical Aspects. Sci Rev Alt Med, 2, 29–35.
  • Curtis, J. D., & Lersten, N. R. (1990). Internal secretory structures in Hypericum (Clusiaceae): H. perforatum L. and H. balearicum L. New Phytologist, 114(4), 571–580.
  • Di Carlo, G., Borrelli, F., Ernst, E., & Izzo, A. A. (2001). St John’s wort: Prozac from the plant kingdom. Trends in Pharmacological Sciences, 22(6), 292–297.
  • Duke, J. A. (1990). CRC Handbook of Medicinal Herbs. In International Clinical Psychopharmacology. https://doi.org/10.1097/00004850-199001000-00014
  • Elmastaş, M., Gülçin, I., Beydemir, Ş., Küfrevioǧlu, Ö. I., & Aboul-Enein, H. Y. (2006). A study on the in vitro antioxidant activity of juniper (Juniperus communis L.) fruit extracts. Analytical Letters, 39, 47–65. https://doi.org/10.1080/00032710500423385
  • Greeson, J. M., Sanford, B., & Monti, D. A. (2001). St. John’s wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology, 153(4), 402–414.
  • Halliwell, B., & Cross, C. E. (1994). Oxygen-derived species: Their relation to human disease and environmental stress. Environmental Health Perspectives, 102(10), 5–12. https://doi.org/10.2307/3432205
  • Halliwell, B., & Gutteridge, J. M. C. (1984). Oxygen toxicity, oxygen radicals, transition metals and disease. Biochemical Journal, 219, 1–14. https://doi.org/10.1042/bj2190001
  • Halliwell, Barry. (1994). Free radicals and antioxidants: a personal view. Nutrition Reviews, 52(8), 253–265.
  • Halliwell, Barry. (1996). Antioxidants in human health and disease. Annual Review of Nutrition, 16(1), 33–50.
  • Herold, A., Cremer, L., Calugăru, A., Tamaş, V., Ionescu, F., Manea, S., & Szegli, G. (2003). Antioxidant properties of some hydroalcoholic plant extracts with antiinflammatory activity. Roumanian Archives of Microbiology and Immunology, 62(3–4), 217–227.
  • Hışıl, Y., Şahin, F., & Omay, S. B. (2005). Kantaronun (Hypericum perforatum L.) bileşimi ve tıbbi önemi. International Journal of Hematology and Oncology, 15, 212–218.
  • Holtom, J. A., & Hylton, W. H. (1979). The Complete Guide to Herbs: How to Grow and Use Nature’s Miracle Plants. Rodale Press. Klemow, K. M., Bartlow, A., Crawford, J., Kocher, N., Shah, J., & Ritsick, M. (2011). 11 Medical Attributes of St. John’s Wort (Hypericum perforatum). Lester Packer, Ph. D., 211–238.
  • Medina, M. A., Martínez-Poveda, B., Amores-Sánchez, M. I., & Quesada, A. R. (2006). Hyperforin: more than an antidepressant bioactive compound? Life Sciences, 79(2), 105–111.
  • Meir, S., Kanner, J., Akiri, B., & Philosoph-Hadas, S. (1995). Determination and involvement of aqueous reducing compounds in oxidative defense systems of various senescing leaves. Journal of Agricultural and Food Chemistry, 43(7), 1813–1819.
  • Miller, A. L. (1998). St. John’s wort (Hypericum perforatum): clinical effects on depression and other conditions. Alternative Medicine Review: A Journal of Clinical Therapeutic, 3(1), 18–26.
  • Nahrstedt, A., & Butterweck, V. (1997). Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry, 30(S 2), 129–134.
  • Oyaizu, M. (1986). Studies on products of browning reaction. Antioxidative activities of products of browning reaction prepared from glucosamine. The Japanese Journal of Nutrition and Dietetics, 44(6), 307–315. https://doi.org/10.5264/eiyogakuzashi.44.307
  • Patocka, J. (2003). The chemistry, pharmacology, and toxicology of the biologically active constituents of the herb Hypericum perforatum L. Journal of Applied Biomedicine, 1(2), 61–70.
  • Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., & Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine, 26(9), 1231–1237. https://doi.org/10.1016/S0891-5849(98)00315
  • Redvers, A., Laugharne, R., Kanagaratnam, G., & Srinivasan, G. (2001). How many patients self-medicate with St John’s wort? Psychiatric Bulletin, 25(7), 254–256.
  • Schempp, C. M., Kirkin, V., Simon-Haarhaus, B., Kersten, A., Kiss, J., Termeer, C. C., … Sleeman, J. P. (2002). Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John’s wort that acts by induction of apoptosis. Oncogene, 21(8), 1242.
  • Sen, C., Packer, L., & Hänninen, O. (2000). Handbook of oxidants and antioxidants in exercise. Elsevier.
  • Soare, J. R., Dinis, T. C. P., Cunha, A. P., & Almeida, L. (1997). Antioxidant activities of some extracts of Thymus zygis. Free Radical Research, 26(5), 469–478.
  • Tümen, G., & Sekendiz, O. (1989). Plants used in traditional medicine in Balıkesir and central villages. Uludağ University Research Funding, Project, (86/12), 19–22.
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Kimya
Bölüm Araştırma Makaleleri
Yazarlar

Abdussamat Güzel 0000-0001-7810-4510

Mehmet Akyüz Bu kişi benim 0000-0001-7971-8389

Murad Aydın Şanda 0000-0001-8843-4361

Yayımlanma Tarihi 31 Aralık 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 1 Sayı: 1

Kaynak Göster

APA Güzel, A., Akyüz, M., & Şanda, M. A. (2019). Determination of Antioxidant activity of Hypericum perforatum. Bütünleyici Ve Anadolu Tıbbı Dergisi, 1(1), 9-18.

Bütünleyici ve Anadolu Tıbbı Dergisi

Journal of Integrative and Anatolian Medicine