Antiviral Etkili Fitoterapötikler: Tıbbi Bitkiler ve Fitokimyasallar

Yıl 2020, Cilt: 1 Sayı: 2, 2 - 20, 09.05.2020

Miray Ege , Mahfuz Elmastaş

Öz

Viral enfeksiyonlar her yıl milyonlarca kişiyi etkiler ve genel olarak ağır seyreden enfeksiyonlara ve hatta ölümlere sebep olurlar. Yaygın olarak kullanılan antiviral ilaçların genellikle etkinlikleri sınırlıdır ve ciddi yan etkilere sebep olabilirler. Bu nedenle etkili yeni antiviral stratejilere halen çok ihtiyaç duyulmaktadır.
Tıbbi bitkiler eski zamanlardan beri terapötik amaçlar için kullanılmaktadır. Antiviral özellikleri ile doğal bazlı fitoterapi viral hastalıkların tedavisi için uygun bir seçenek olabilir. Genel olarak viral replikasyonun inhibisyonu çoğu zaman doğal ürünlerin antiviral aktivitesi için genel bir mekanizma olarak düşünülse de çalışmalar bazı doğal ürünlerin virülans ile ilişkili anahtar viral proteinlerle etkileşime girebileceğini göstermiştir. Bu anlamda, bazı doğal kaynaklı bileşiklerin kendileri veya bir ana şablon olarak kullanılarak sentezlenen türevleri, daha etkili yeni antiviral ilaç tasarımlarının geliştirilmesine ışık tutabilir. Ayrıca antiviral aktiviteye sahip çok sayıda doğal ürün, bazı epidemilerde genel popülasyonun bağışıklığını arttırmak için kullanılabilecek gıda takviyelerinin de ana bileşenleridir. Antiviral tedavinin zorlukları ve olasılıkları göz önüne alındığında bu çalışma; tıbbi bitkiler ve antiviral aktiviteye sahip olan fitokimyasallar hakkında kanıta dayalı verileri derlemeyi amaçlamaktadır.

Anahtar Kelimeler

Antiviral, fitoterapötikler, tıbbi bitkiler, fitokimyasallar

Destekleyen Kurum

Bulunmamaktadır.

Phytotherapeutics with Antiviral Effect: Medicinal Plants and Phytochemicals

Öz

Viral infections affect millions of people each year and generally cause severe infections and even deaths. Commonly used antiviral drugs often have limited efficacy and can cause serious side effects, and therefore effective new antiviral strategies are still needed.
Medicinal plants have been used for therapeutic purposes since ancient times and natural-based phytotherapeutics with their antiviral properties can be an effective option for the treatment of viral diseases. Although inhibition of viral replication is often thought to be a general mechanism for antiviral activity of natural products, studies have shown that some natural products may also interact with virulence-related key viral proteins. In this sense, derivatives of some naturally sourced compounds themselves or synthesized using them as a master template may shed light on developing more effective new antiviral drug designs. In addition, many natural products with antiviral activity are the main components of food supplements that can be used in some epidemics to increase the immunity of the general population. Given the challenges and possibilities of antiviral therapy, this study aims to compile evidence-based data on medicinal plants and related phytochemicals with antiviral activity.

Anahtar Kelimeler

Antiviral, phytotherapeutics, medicinal plant, phytochemicals

Kaynakça

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