Luteolin Molekülü Covid-19 ile Mücadelede Bir Seçenek Olabilir mi?

Yıl 2021, Cilt: 2 Sayı: 3, 78 - 89, 24.10.2021

Fatime Betül Üzer

https://doi.org/10.53445/batd.925584

Cited By: 2

Öz

SARS-Cov-2 tüm dünyayı etkisi altına alan ve inhibisyonuna yönelik henüz kesin bir tedavi yöntemi geliştirilememiş bir virüstür. Mevcut tedavi protokolleri yeterli çözüm ortaya koyamamıştır. Virüs inhibisyonuna yönelik yapılan moleküler docking çalışmalarında doğal ürünler arasında Luteolin molekülü öne çıkmaktadır. Luteolin molekülü, Origanum vulgare, Apium graveolens, Thymus vulgaris başta olmak üzere birçok bitkide doğal olarak bulunan bir moleküldür. Luteolin, İran, Brezilya ve geleneksel Çin Tıbbında enflamasyon ile birlikte devam eden hastalıkların tedavisinde uzun süredir kullanılagelmiştir. Antioksidan, antimikrobial, antienflamatuar, kemopreventif, kemoterapötik, kardioprotektif, antidiabetik, nöroprotektif ve antialerjik özelliklere sahip, termostabil bir moleküldür. Luteolin molekülü SARS-Cov-2’nin hücre içine girerken kullandığı furin bağlanma bölgesine bağlanarak, virüsün hücre içine girmesini engelleyebilir. Mevcut kullanım alanları, etki mekanizmaları, SARS-CoV-2 patofizyolojisi ve moleküler docking çalışmaları birlikte değerlendirildiğinde, Covid-19 ile mücadelede Luteolin molekülü umut verici bir terapötik ajan olarak öne çıkmaktadır.

Anahtar Kelimeler

SARS-CoV-2, Covid-19, Luteolin, Furin, Doğal ürün

Teşekkür

Değerli katkılarından dolayı Prof. Dr. Mahfuz Elmastaş ve Doç. Dr. Zafer Ömer Özdemir hocalarıma teşekkür ederim.

Could Luteolin Molecule be an Option in Combating Covid-19?

Öz

SARS-CoV-2 is a virus that has affected the whole world and a definitive treatment method for its inhibition has not yet been developed. Current treatment protocols have not been able to provide a sufficient solution. As a result of molecular docking studies for virus inhibition, it is seen that the Luteolin molecule stands out among natural products. Luteolin molecule is a molecule found naturally in many plants, especially Origanum vulgare, Apium graveolens, Thymus vulgaris. Luteolin has long been used in Iran, Brazil, and traditional Chinese Medicine to treat illnesses with inflammation. It is a thermostable molecule with antioxidant, antimicrobial, anti-inflammatory, chemopreventive, chemotherapeutic, cardioprotective, antidiabetic, neuroprotective and antiallergic properties. The luteolin molecule can bind to the furin binding site that SARS-CoV-2 uses to enter the cell, thereby preventing the virus from entering the cell. When the current usage areas, mechanisms of action, SARS-CoV-2 pathophysiology and molecular docking studies are evaluated, Luteolin molecule stands out as a promising therapeutic agent in the fight against Covid-19.

Anahtar Kelimeler

Covid-19, Luteolin, Furin, Natural product, SARS-CoV-2

Kaynakça

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