Mutasyonların şugoşinin perisentromerik lokalizasyonu üzerindeki etkileri

Öz

Mutasyonların protein-protein etkileşimleri üzerindeki etkilerinin aydınlatılması, kromozom segregasyonları gibi biyolojik fonksiyonlardaki hasarlarn tespiti için faydalı olabilir, çünkü hücresel yapı ve fonksiyonlar esas olarak proteinlerin uyumlu etkileşimleri üzerine kuruludur. Shugoshin (Sgo1), mitoz ve mayoz bölünme sırasında doğru kromozom ayrımında birçok rolü olan proteinlerden biridir. Sgo1'in düzgün çalışması için gerekli olan faktörlerden biri, bu proteinin sentromeri çevreleyen (perisentromer) kromozomal bölgede bulunması gerekliliğidir. Bununla birlikte, bazı mutasyonlar Sgo1'in lokalizasyonunu doğrudan veya dolaylı olarak etkileyebilir ve anöploidi, kanser ve diğer hastalıklarla sonuçlanabilen kromozom kazanımı/kaybı olarak bilinen kromozomal kararsızlığa neden olabilir. Bu nedenle, bu makale Sgo1'in perisentromerik lokalizasyonunu etkileyen mutasyonlara odaklanmaktadır.

Anahtar Kelimeler

• Şugoşin
• perisentromer
• mutasyon
• kromozomal instabilite
• anöploidi

The effects of mutations on pericentromeric localization of shugoshin

Öz

Elucidating the effects of mutations on protein-protein interactions can be useful for detecting damaged biological functions like chromosome segregations, because cellular structure and functions are mainly built on concerted interactions of proteins. Shugoshin (Sgo1) is one of those proteins that has many roles in correct chromosome segregation during mitosis and meiosis. One of the important aspects about Sgo1, to function properly, is the fact that it has to be on the chromosomal region surrounding the centromere (the pericentromere). However, some mutations can directly or indirectly affect the localization of Sgo1 and result in chromosomal instability which is known as the occasional gain/loss of chromosomes resulting in aneuploidy, cancer and other diseases. Therefore, this review focuses on the mutations that affect the pericentromeric localization of Sgo1.

Anahtar Kelimeler

• Shugoshin
• pericentromere
• mutation
• chromosomal instability
• aneuploidy

Kaynakça

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