İneklerde Vitamin A, D ve E’nin Fertilite Üzerine Etkisi: Derleme

Öz

İneklerde vitamin A, D ve E takviyeleri, üreme sağlığını desteklemek, doğum sonrası enfeksiyonları önlemek ve fertiliteyi artırmak açısından kritik bir öneme sahiptir. Doğum öncesi ve sonrası dönemlerde yapılan uygun doz ve zamanlamadaki takviyeler, retensiyo sekundinarum ve metritis gibi enfeksiyonların sıklığını azaltırken, postpartum ilk östrüs süresini kısaltmakta ve gebelik oranlarını iyileştirmektedir. Vitamin A, üreme fonksiyonlarında ve bağışıklık sisteminde destekleyici bir rol üstlenirken, D vitamini kalsiyum dengesini koruyarak kemik mineralizasyonuna katkıda bulunmaktadır. E vitamini, güçlü antioksidan özellikleriyle hücre zarlarını koruyarak bağışıklık sistemini destekler. Bu vitaminlerin doğru bir şekilde uygulanması, ineklerde doğum sonrası toparlanmayı hızlandırmak ve genel sağlık durumunu iyileştirmek için etkili bir stratejidir. Bu nedenle bu vitaminlerin kullanımı ile ilgili veteriner hekimlerin güncel detaylı bilgilere ulaşması büyük bir önem arz etmektedir. Sunulan derlemede saha uygulamalarında yaygın olarak kullanılan A, D ve E vitaminlerinin fertilite üzerindeki etkileri ve uygulama stratejileri ile ilgili güncel bilgilere yer verilmeye çalışılmıştır.

Anahtar Kelimeler

• İnek
• fertilite
• vitamin A
• vitamin D
• vitamin E

The Effect of Vitamins A, D and E on Fertility in Cows: Review

Öz

Vitamin A, D and E supplements are critical to support reproductive health, prevent postpartum infections and increase fertility in cows. Appropriate doses and timing of supplements in the pre- and postnatal periods reduce the frequency of infections such as retensio secundinarum and metritis, shorten the duration of the first postpartum oestrus and improve pregnancy rates. Vitamin A plays a supportive role in reproductive function and the immune system, while vitamin D contributes to bone mineralisation by maintaining calcium balance. Vitamin E supports the immune system by protecting cell membranes with its powerful antioxidant properties. The correct administration of these vitamins is an effective strategy to accelerate postpartum recovery and improve overall health status in cows. Therefore, it is of great importance for veterinarians to have up-to-date detailed information on the use of these vitamins. In the present review, it has been tried to include current information on the effects of vitamins A, D and E on fertility and application strategies, which are widely used in field applications.

Anahtar Kelimeler

• Cow
• fertility
• vitamin A
• vitamin D

Kaynakça

1. Abay, M., Bekyürek, T. (2010). Effectiveness of two different GnRH analogues with or without beta-carotene and vitamin E supplementation in ovsynch protocol in Heifers. 14th Annual Conference of the European Societies Domestic Animals Reproduction, 45(3), 84, Hungary.
2. Agarwal, A., Allamaneni, S.S. (2004). Role of free radicals in female reproductive diseases and assisted reproduction. Reproductive biomedicine online, 9(3), 338-347, https://doi.org/10.1016/S1472-6483(10)62151-7
3. Aksoy, A., Daş, Y.K. (2012). Vitaminlerin Veteriner Sağaltımda Kullanımı. Turkiye Klinikleri J Vet Sci, 3(3), 65-76.
4. Allison, R. D., Laven, R. A. (2000). Effect of vitamin E supplementation on the health and fertility of dairy cows: a review. Veterinary Record, 147(25), 703-708, https://doi.org/10.1136/vr.147.25.703
5. Altıner, A., Atalay, H., Bilal, T. (2017). Bir antioksidan olarak E vitamini. Balıkesir Sağlık Bilimleri Dergisi, 6(3), 149-157, https://dx.doi.org/10.5505/bsbd.2017.47450
6. Amengual, J., Golczak, M., Palczewski, K., Von Lintig, J. (2012). Lecithin: retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. Journal of Biological Chemistry, 287(29), 24216-24227.
7. Arechiga, C. F., Vazquez-Flores, S., Ortiz, O., Hernandez-Ceron, J., Porras, A., McDowell, L. R., Hansen, P. J. (1998). Effect of injection of β-carotene or vitamin E and selenium on fertility of lactating dairy cows. Theriogenology, 50(1), 65-76, https://doi.org/10.1016/S0093-691X(98)00114-9
8. Azzi, A., Ricciarelli, R., Zingg, J. M. (2002). Non-antioxidant molecular functions of α-tocopherol (vitamin E). FEBS letters, 519(1-3), 8-10, https://doi.org/10.1016/S0014-5793(02)02706-0

9. Balamurugan, B., Ramamoorthy, M., Mandal, R. S. K., Keerthana, J., Gopalakrishnan, G., Kavya, K., Katiyar, R. (2017). Mineral an important nutrient for efficient reproductive health in dairy cattle. Int. J. Environ. Sci. Technol, 6(1), 694-701.
10. Belorusova, A. Y., Rochel, N. (2016). Structural studies of vitamin D nuclear receptor ligand-binding properties. Vitamins & Hormones, 100, 83-116, https://doi.org/10.1016/bs.vh.2015.10.003
11. Bentes, C. M., Resende, M., Miranda, H., Netto, C. C., & Marinheiro, L. P. (2018). Can Vitamin D supplementation alone effective to increase a physical fitness levels in post-menopausal women with metabolic disorders? Brief Review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 12(1), 65-68. https://doi.org/10.1016/j.dsx.2017.08.010
12. Bilgiç, S., Aktaş, İ. (2023). Antioksidan İçeren Besinler 3. Cilt. İksad Yayınevi, Ankara, https://doi.org/10.5281/zenodo.10207212
13. Bindari, Y. R., Shrestha, S., Shrestha, N., Gaire, T. N. (2013). Effects of nutrition on reproduction-A review. Advances in Applied Science Research, 4(1), 421-429.
14. Bisinotto, R. S., Greco, L. F., Ribeiro, E. S., Martinez, N., Lima, F. S., Staples, C. R., Santos, J. E. P. (2018). Influences of nutrition and metabolism on fertility of dairy cows. Animal Reproduction (AR), 9(3), 260-272.
15. Bonrath, W., Gao, B., Houston, P., McClymont, T., Müller, M. A., Schäfer, C., Medlock, J. A. (2023). 75 years of vitamin A production: a historical and scientific overview of the development of new methodologies in chemistry, formulation, and biotechnology. Organic Process Research & Development, 27(9), 1557-1584, https://doi.org/10.1021/acs.oprd.3c00161
16. Brzezinska-Slebodzinska, E., Miller, J. K., Quigley III, J. D., Moore, J. R., Madsen, F. C. (1994). Antioxidant status of dairy cows supplemented prepartum with vitamin E and selenium. Journal of Dairy Science, 77(10), 3087-3095, https://doi.org/10.3168/jds.S0022-0302(94)77251-9
17. Campbell, M. H., Miller, J. K. (1998). Effect of supplemental dietary vitamin E and zinc on reproductive performance of dairy cows and heifers fed excess iron. Journal of dairy science, 81(10), 2693-2699, https://doi.org/10.3168/jds.S0022-0302(98)75826-6
18. Cemeroğlu, B.S., Karadeniz, F., Özkan, M. (2003). Meyve ve Sebze İşleme Teknolojisi. Gıda Teknolojisi Derneği Yayınları, 28, 541, Ankara.
19. Chew, B.P. (1995). Antioxidant vitamins affect food animal immunity and health. Journal of Nutrition, 125: 1804-1808, https://doi.org/10.1093/jn/125.suppl_6.1804S
20. Chew, B.P. (1993). Effects of supplemental β-carotene and vitamin A on reproduction in swine. J Anim Sci, 71(1): 247-252, https://doi.org/10.2527/1993.711247x
21. Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L., Carmeliet, G. (2016). Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological reviews, 96(1), 365-408, https://doi.org/10.1152/physrev.00014.2015
22. Cleal, J. K., Hargreaves, M. R., Poore, K. R., Tang, J. C., Fraser, W. D., Hanson, M. A., Green, L. R. (2017). Reduced fetal vitamin D status by maternal undernutrition during discrete gestational windows in sheep. Journal of developmental origins of health and disease, 8(3), 370-381, https://doi.org/10.1017/S2040174417000149
23. Coelho, M. B. (1991). Functions of vitamin E. Vitamin E in Animal Nutrition and Management, 11-17. Colotta, F., Jansson, B., Bonelli, F. (2017). Modulation of inflammatory and immune responses by vitamin D. Journal of autoimmunity, 85, 78-97, https://doi.org/10.1016/j.jaut.2017.07.007
24. Cornell, L., Arita, K., Goodrich, R. (2020). Fat-Soluble Vitamins: A, E, and K. In: Pitchumoni, C.S., Dharmarajan, T. (eds) Geriatric Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-90761-1_22-1
25. Das, S., Chattopadhyay, R., Ghosh, S., Ghosh, S., Goswami, S. K., Chakravarty, B. N., Chaudhury, K. (2006). Reactive oxygen species level in follicular fluid—embryo quality marker in IVF?. Human reproduction, 21(9), 2403-2407, https://doi.org/10.1093/humrep/del156
26. Daşkın, A. (2005). Sığırcılık İşletmelerinde Reprodüksiyon Yönetimi ve Suni Tohumlama Kitabı, 226-244, Uğurer Tarım Yayınevi, Ankara.
27. Debski, B., Nowicki, T., Zalewski, W., Ochota, M., Mrowiec, J., Twardon, J. (2016). Evaluation of acute phase proteins in clinically healthy dairy cows in perinatal period and during lactation. Pol. J. Vet. Sci., 19:519–523, https://doi.org/10.1515/pjvs-2016-0065
28. Erskine, R. J., Bartlett, P. C., Herdt, T., Gaston, P. (1997). Effects of parenteral administration of vitamin E on health of periparturient dairy cows. Journal of the American Veterinary Medical Association, 211(4), 466-469, https://doi.org/10.2460/javma.1997.211.04.466
29. Faisel, H., Pittrof, R. (2000). Vitamin A and causes of maternal mortality: association and biological plausibility. Public Health Nutrition, 3(3), 321-327, https://doi.org/10.1017/S1368980000000367
30. Garcia, M., Seelaender, M., Sotiropoulos, A., Coletti, D., Lancha Jr, A. H. (2019). Vitamin D, muscle recovery, sarcopenia, cachexia, and muscle atrophy. Nutrition, 60, 66-69, https://doi.org/10.1016/j.nut.2018.09.031
31. Glynn, R. J., Ridker, P. M., Goldhaber, S. Z., Zee, R. Y., Buring, J. E. (2007). Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women’s Health Study. Circulation, 116(13), 1497-1503, https://doi.org/10.1161/CIRCULATIONAHA.107.716407
32. Goff, J. P. (2008). The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. The veterinary journal, 176(1), 50-57, https://doi.org/10.1016/j.tvjl.2007.12.020
33. Grilo, E. C., Medeiros, W. F., Silva, A. G. A., Gurgel, C. S. S., Ramalho, H. M. M., Dimenstein, R. (2016). Maternal supplementation with a megadose of vitamin A reduces colostrum level of α‐tocopherol: a randomised controlled trial. Journal of human nutrition and dietetics, 29(5), 652-661, https://doi.org/10.1111/jhn.12381
34. Grundmann, M., von Versen-Höynck, F. (2011). Vitamin D-roles in women's reproductive health?. Reproductive biology and endocrinology, 9, 1-12, https://doi.org/10.1186/1477-7827-9-146
35. Gunville, C. F., Mourani, P. M., Ginde, A. A. (2013) The role of vitamin D in prevention and treatment of infection. Inflamm. Allergy Drug Targets, 12, 239-245.
36. Hafez, E.S.E., Hafez, B. (2000). Reproduction in Farm Animals. Editors: Hafez ESE, Hafez B. In: Reproductive Cycles. 7th Ed., Wiley-Blackwell, Oxford, 55-67.
37. Haliloglu, S., Baspinar, N., Serpek, B., Erdem, H., Bulut, Z. (2002). Vitamin A and β‐carotene levels in plasma, corpus luteum and follicular fluid of cyclic and pregnant cattle. Reproduction in Domestic Animals, 37(2), 96-99, https://doi.org/10.1046/j.1439-0531.2002.00338.x
38. Hammon, D., Evjen, I. M., Dhiman, T. R., Goff, J. P., Walters, J. L. (2006). Neutrophil function and energy status in Holstein cows with uterine health disorders. Veterinary immunology and immunopathology, 113(1-2), 21-29, https://doi.org/10.1016/j.vetimm.2006.03.022
39. Hayırlı, A., Çolak, A. (2011). İneklerin kuru ve geçiş dönemlerinde sevk-idare ve besleme stratejileri: postpartum süreçte metabolik profil, sağlık durumu ve fertiliteye etkisi. Turkiye Klinikleri Journal of Veterinary Science, 2, 1-35.
40. Heaney, R. P., Armas, L. A. (2015). Quantifying the vitamin D economy. Nutrition Reviews, 73, 51-67, https://doi.org/10.1093/nutrit/nuu004
41. Holcombe, S. J., Wisnieski, L., Gandy, J., Norby, B., Sordillo, L. M. (2018). Reduced serum vitamin D concentrations in healthy early-lactation dairy cattle. Journal of dairy science, 101(2), 1488-1494, https://doi.org/10.3168/jds.2017-13547
42. Holick, M. F. (2005). The vitamin D epidemic and its health consequences. The Journal of nutrition, 135(11), 2739-2748, https://doi.org/10.1093/jn/135.11.2739S
43. Holick, M. F. (2007). Vitamin D deficiency. N Engl J Med, 357(3), 266-281.
44. Horst, R. L., Goff, J. P., Renhardt, T. A. (2003). Role of vitamin D in calcium homeostasis and its use in prevention of bovine periparturient paresis. Acta Vet Scan Supp, 97, 35-50.
45. Hymøller, L., Jensen, S. K., Lindqvist, H., Johansson, B., Nielsen, M. O., Nadeau, E. (2009). Supplementing dairy steers and organically managed dairy cows with synthetic vitamin D3 is unnecessary at pasture during exposure to summer sunlight. Journal of dairy research, 76(3), 372-378, https://doi.org/10.1017/S0022029909004130
46. Hymøller, L., Jensen, S. K. (2010). Vitamin D3 synthesis in the entire skin surface of dairy cows despite hair coverage. Journal of dairy science, 93(5), 2025-2029, https://doi.org/10.3168/jds.2009-2991
47. Jakobsen, J., Jensen, S. K., Hymøller, L., Andersen, E. W., Kaas, P., Burild, A., Jäpelt, R. B. (2015). Artificial ultraviolet B light exposure increases vitamin D levels in cow plasma and milk. Journal of Dairy Science, 98(9), 6492-6498, https://doi.org/10.3168/jds.2014-9277
48. Jaskowski, J. M. (1993). The effect of antepartum doses of selenium vitamin E combinations on the incidence of puerperal disorders in cattle. Tierarztliche Praxis, 21, 111-116.
49. Kandelousi, M., Alamouti, A. A., Imani, M., Zebeli, Q. (2020). A meta-analysis and meta-regression of the effects of vitamin E supplementation on serum enrichment, udder health, milk yield, and reproductive performance of transition cows. Journal of dairy science, 103(7), 6157-6166. https://doi.org/10.3168/jds.2019-17556
50. Karabulut, H., Gülay, M. Ş. (2016). Antioksidanlar. Veterinary Journal of Mehmet Akif Ersoy University, 1(1), 65-76, https://doi.org/10.24880/maeuvfd.260790
51. Kaya, S., Bilgili, A. (1997). Veteriner Uygulamalı Farmakoloji, Editörler: Kaya, S., Pirinçci, İ., Bilgili, A. Beslenme Farmakolojisi Cilt 1-2, 217-270, Medisan Yayınevi, Ankara.
52. Kennel, K. A., Drake, M. T., Hurley, D. L. (2010). Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc, 85(8), 752-758, https://doi.org/10.4065/mcp.2010.0138
53. Khatti, A., Mehrotra, S., Patel, P. K., Singh, G., Maurya, V. P., Mahla, A. S., Krishnaswamy, N. (2017). Supplementation of vitamin E, selenium and increased energy allowance mitigates the transition stress and improves postpartum reproductive performance in the crossbred cow. Theriogenology, 104, 142-148, https://doi.org/10.1016/j.theriogenology.2017.08.014
54. Koramaz, G. (2020). Honamlı ve kıl keçi kolostrumlarındaki A, D3 ve E vitamin düzeylerinde doğumdan sonraki 5 gün süredeki değişimlerin belirlenmesi. (Doktora Tezi). Burdur Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü, Burdur.
55. Lean, I. J., Van Saun, R., Degaris, P. J. (2013). Mineral and antioxidant management of transition dairy cows. Veterinary Clinics of North America: Food Animal Practice, 29(2), 367-386.
56. Lerchbaum, E., Obermayer-Pietsch, B. (2012). Mechanisms in endocrinology: Vitamin D and fertility: a systematic review. European journal of endocrinology, 166(5), 765-778, https://doi.org/10.1530/EJE-11-0984
57. Lewis, E. D., Meydani, S. N., Wu, D. (2019). Regulatory role of vitamin E in the immune system and inflammation. IUBMB Life, 71(4), 487-494, https://doi.org/10.1002/iub.1976.
58. Lin, R. (2016). Crosstalk between vitamin D metabolism, VDR signalling, and innate immunity. BioMed research international, 2016(1), 1375858, https://doi.org/10.1155/2016/1375858
59. Lin, X., Meng, X., Song, Z. (2019). Vitamin D and alopecia areata: possible roles in pathogenesis and potential implications for therapy. American journal of translational research, 11(9), 5285.
60. Malloy, P. J., Peng, L., Wang, J., Feldman, D. (2009). Interaction of the vitamin D receptor with a vitamin D response element in the Mullerian-inhibiting substance (MIS) promoter: regulation of MIS expression by calcitriol in prostate cancer cells. Endocrinology, 150(4), 1580-1587, https://doi.org/10.1210/en.2008-1555
61. Martinez, N., Rodney, R. M., Block, E., Hernandez, L. L., Nelson, C. D., Lean, I. J., Santos, J. E. P. (2018). Effects of prepartum dietary cation-anion difference and source of vitamin D in dairy cows: Health and reproductive responses. Journal of dairy science, 101(3), 2563-2578, https://doi.org/10.3168/jds.2017-13740
62. Martinez, N., Risco, C. A., Lima, F. S., Bisinotto, R. S., Greco, L. F., Ribeiro, E. S., Santos, J. E. P. (2012). Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease. Journal of dairy science, 95(12), 7158-7172, https://doi.org/10.3168/jds.2012-5812
63. McDowell, L. R. (2000). Vitamins in Animal Nutrition Comparative Aspects to Human Nutrition. Academic Press Inc, 93-131, California.
64. Mehdi, Y., Dufrasne, I. (2016). Selenium in cattle: a review. Molecules, 21(4), 545.https://doi.org/10.3390/molecules21040545
65. Merhi, Z., Doswell, A., Krebs, K., Cipolla, M. (2014). Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. The Journal of Clinical Endocrinology & Metabolism, 99(6), E1137-E1145, https://doi.org/10.1210/jc.2013-4161
66. Muscogiuri, G., Altieri, B., de Angelis, C., Palomba, S., Pivonello, R., Colao, A., Orio, F. (2017). Shedding new light on female fertility: The role of vitamin D. Reviews in Endocrine and Metabolic Disorders, 18, 273-283, https://doi.org/10.1007/s11154-017-9407-2
67. Nelson, C. D., Reinhardt, T. A., Beitz, D. C., Lippolis, J. D. (2010). In vivo activation of the intracrine vitamin D pathway in innate immune cells and mammary tissue during a bacterial infection. PloS one, 5(11), e15469, https://doi.org/10.1371/journal.pone.0015469
68. Nelson, C. D., Reinhardt, T. A., Lippolis, J. D., Sacco, R. E., Nonnecke, B. J. (2012). Vitamin D signaling in the bovine immune system: a model for understanding human vitamin D requirements. Nutrients, 4(3), 181-196, https://doi.org/10.3390/nu4030181
69. Nelson, C. D., Merriman, K. E. (2014). Vitamin D metabolism in dairy cattle and implications for dietary requirements. In 25th Annual Florida Ruminant Nutrient Symposium, 78-90.
70. Nelson, C. D., Powell, J. L., Price, D. M., Hersom, M. J., Yelich, J. V., Drewnoski, M. E., Bridges, G. A. (2016a). Assessment of serum 25-hydroxyvitamin D concentrations of beef cows and calves across seasons and geographical locations. Journal of Animal Science, 94(9), 3958-3965, https://doi.org/10.2527/jas.2016-0611
71. Nelson, C. D., Lippolis, J. D., Reinhardt, T. A., Sacco, R. E., Powell, J. L., Drewnoski, M. E., Weiss, W. P. (2016b). Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry. Journal of dairy science, 99(12), 10150-10160, https://doi.org/10.3168/jds.2016-11727
72. Öngen, B., Kabaroğlu, C., Parıldar, Z. (2008). D vitamininin biyokimyasal ve laboratuvar değerlendirmesi. Türk Klinik Biyokimya Dergisi, 6, 23-31.
73. Paffoni, A., Ferrari, S., Viganò, P., Pagliardini, L., Papaleo, E., Candiani, M., Somigliana, E. (2014). Vitamin D deficiency and infertility: insights from in vitro fertilization cycles. The Journal of Clinical Endocrinology & Metabolism, 99(11), E2372-E2376, https://doi.org/10.1210/jc.2014-1802
74. Pontes, G. C. D. S., Monteiro Jr, P. L. J., Prata, A. B., Guardieiro, M. M., Pinto, D. A. M., Fernandes, G. O., Sartori, R. (2015). Effect of injectable vitamin E on incidence of retained fetal membranes and reproductive performance of dairy cows. Journal of dairy science, 98(4), 2437-2449, https://doi.org/10.3168/jds.2014-8886
75. Pu, Y., Wang, Z., Bian, Y., Zhang, F., Yang, P., Li, Y., Zhang, X. (2014). All‐trans retinoic acid improves goat oocyte nuclear maturation and reduces apoptotic cumulus cells during in vitro maturation. Animal Science Journal, 85(9), 833-839, https://doi.org/10.1111/asj.12216
76. Qureshi, Z. I, Siddiq, M., Lodhi, L. A., Muhammad, G., Jamil, H. (2009). Effect of vitamin E-selenium administration during late gestation on productive and reproductive performance in dairy buffaloes and on growth performance of their calves. Pakistan Veterinary Journal, 30(2), 83-86.
77. Radostits, O. M., Gay, C. C., Hinchcliff, K. W., Constable, P. D. (2007). A textbook of the diseases of cattle, horses, sheep, pigs and goats. Vet. Med, 10, 2045-2050.
78. Ribeiro, E. S., Gomes, G., Greco, L. F., Cerri, R. L. A., Vieira-Neto, A., Monteiro Jr, P. L. J., Santos, J. E. P. (2016). Carryover effect of postpartum inflammatory diseases on developmental biology and fertility in lactating dairy cows. Journal of dairy science, 99(3), 2201-2220, https://doi.org/10.3168/jds.2015-10337
79. Roche, J. R., Burke, C. R., Crookenden, M. A., Heiser, A., Loor, J. L., Meier, S., Turner, S. A. (2018). Fertility and the transition dairy cow. Reproduction, Fertility and Development, 30(1), 85-100, https://doi.org/10.1071/RD17412
80. Rode, L. M., Coulter, G. H., Kastelic, J. P., Bailey, D. R. C. (1995). Seminal quality and sperm production in beef bulls with chronic dietary vitamin A deficiency and subsequent re-alimentation. Theriogenology, 43(7), 1269-1277, https://doi.org/10.1016/0093-691X(95)00098-S
81. Shastak, Y., Obermueller-Jevic, U., Pelletier, W. (2023). A century of vitamin E: Early milestones and future directions in animal nutrition. Agriculture, 13(8), 1526, https://doi.org/10.3390/agriculture13081526
82. Sönmez, M., Bozkurt, T., Türk, G., Gür, S., Kızıl, M., Yüce, A. (2009). The effect of vitamin E treatment during preovulatory period on reproductive performance of goats following estrous synchronization using intravaginal sponges. Animal Reproduction Science, 114(1-3), 183-192, https://doi.org/10.1016/j.anireprosci.2008.09.007
83. Starič, J. (2010). Dynamics of biochemical markers of bone metabolism in dairy cows treated with high dose of vitamin D3 as prevention against periparturient hypocalcaemia. (PhD thesis). University of Ljubljana, Veterinary Faculty, Slovenia.
84. Şahin, N. (2008). Vitaminler. Hayvan Besleme ve Beslenme Hastalıkları. 85-112, Medipres, Malatya. Trojačanec, S., Boboš, S., Pajić, M. (2012). Influence of β-carotene and vitamin A supplementation on the ovarian activity of dairy cows with chronic fertility impairment. Veterinarski Arhiv, 82(6), 567-575.
85. Tuncer, Ş. D. (2008). Hayvan Besleme ve Beslenme Hastalıkları. Ergün, A., Tuncer, Ş. D., Çolpan, İ,, Yalçın, S., Yıldız, G., Küçükersan, M. K., Küçükersan, S., Şehu, A. (Ed). Süt Sığırlarının Beslenmesi. 253-299, Ankara.
86. Turan, Ö. D. (2018). Vitamin D Level and Infertility. Meandros Med Dental J, 19(2), 106-110, https://doi.org/10.4274/meandros.2399
87. Turner, R. J., Finch, J. M. (1991). Selenium and the immune response. Proceedings of the Nutrition Society, 50(2), 275-285, https://doi.org/10.1079/PNS19910037
88. Valastyan, S., Thakur, V., Johnson, A., Kumar, K., Manor, D. (2008). Novel transcriptional activities of vitamin E: inhibition of cholesterol biosynthesis. Biochemistry, 47(2), 744-752, https://doi.org/10.1021/bi701432q
89. Verstuyf, A., Carmeliet, G., Bouillon, R., Mathieu, C. (2010). Vitamin D: a pleiotropic hormone. Kidney international, 78(2), 140-145, https://doi.org/10.1038/ki.2010.17
90. Xiao, J., Khan, M. Z., Ma, Y., Alugongo, G. M., Ma, J., Chen, T., Cao, Z. (2021). The antioxidant properties of selenium and vitamin E; their role in periparturient dairy cattle health regulation. Antioxidants, 10(10), 1555, https://doi.org/10.3390/antiox10101555
91. Xu, J., Lawson, M. S., Xu, F., Du, Y., Tkachenko, O. Y., Bishop, C. V., Hennebold, J. D. (2018). Vitamin D3 regulates follicular development and intrafollicular vitamin D biosynthesis and signaling in the primate ovary. Frontiers in physiology, 9, 1600, https://doi.org/10.3389/fphys.2018.01600
92. Yao, X., Wang, Z., El-Samahy, M. A., Ren, C., Liu, Z., Wang, F., You, P. (2020). Roles of vitamin D and its receptor in the proliferation and apoptosis of luteinised granulosa cells in the goat. Reproduction, Fertility and Development, 32(3), 335-348, https://doi.org/10.1071/RD18442
93. Yazıcıoğlu, Ö. (1994). Sığırlarda hipovitaminosis-A. Etlik Veteriner Mikrobiyoloji Dergisi, 7(5), 183-194. Yeşil, M., Sarıözkan, S. (2017). Dişi üreme sistemi açısından önemli bazı vitamin ve mineraller. Erciyes Üniv Vet Fak Derg, 14(3), 201-208.
94. Yılmaz, N., Seven, B. (2021) Üreme Sağlığı ve D Vitamini. Turkish Journal of Reproductive Medicine and Surgery, 5(1), 36-42, https: doi.org//10.24074/tjrms.2020-80791
95. Zafalon, R. V. A., Ruberti, B., Rentas, M. F., Amaral, A. R., Vendramini, T. H. A., Chacar, F. C., Brunetto, M. A. (2020). The role of vitamin D in small animal bone metabolism. Metabolites, 10(12), 496, https://doi.org/10.3390/metabo10120496
96. Zingg, J. M. (2007). Vitamin E: an overview of major research directions. Molecular aspects of medicine, 28(5-6), 400-422, https://doi.org/10.1016/j.mam.2007.05.004