A study of the anticancer effect of 1,8 cineole: Molecular docking analysis

Yıl 2024, , 50 - 55, 31.03.2024

Bilge Bıçak

https://doi.org/10.30516/bilgesci.1415844

Öz

Since cancer is a serious disease that affects many people around the world, scientists focus on studies on the diagnosis and treatment of cancer. Plants have been used for therapeutic purposes for many years. Plants that form the basis of traditional medicine contain therapeutic compounds. These compounds have important properties such as anticancer, anti-inflammatory, analgesic, antimicrobial and antioxidant. Essential oils obtained from various plants are known to have therapeutic effects. Terpenes make up the largest part of the composition of plant essential oils. Terpenes have various beneficial effects such as anti-anxiety, anti-depressant, anti-inflammatory, anti-bacterial, anti-cancer, analgesic and mood-boosting. 1,8 cineole is one of the monoterpene compounds found in essential oils. 1,8 cineole is an important compound with various properties such as antioxidant, anti-inflammatory and anticancer. The molecular docking method is one of the computational modeling methods used in drug development programs. In this study, the interactions of 1,8 cineole, which is known to have anticancer properties, with various receptors prominent in anticancer studies (estrogen receptor beta (ER-β), epidermal growth factor receptor (EGFR), Receptor tyrosine-protein kinase erbB-2 (HER2) and Tankyrase 1) were examined with the help of the molecular docking method, the interaction profile was determined and presented in comparison with literature studies. As a result of docking studies, it was predicted that the interaction with Tankyrase-1 would be stronger.

Anahtar Kelimeler

Essential oil, Molecular docking, Cancer, Plant

Destekleyen Kurum

The authors declared that this study has received no financial support.

Teşekkür

I would like to thank Prof. Dr. Uğur Gündüz and Prof. Dr. Serda Kecel Gündüz for their support.

Kaynakça

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