Klinik Araştırma
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Türkiye’nin Bingöl İlindeki Süt İneklerinde Ketozis Prevalansının Araştırılması

Yıl 2024, Cilt: 5 Sayı: 3, 621 - 628, 07.12.2024
https://doi.org/10.58605/bingolsaglik.1552396

Öz

Bu çalışmanın amacı Bingöl ilinin 7 farklı köyünde (Alibir, Ardıçtepe, Çavuşlar, Garip, Sudüğünü, Yamaç ve Yeşil) ketozis prevalansını araştırmaktır. Araştırmada doğumdan sonraki 3 haftalık süreçte Simmental, Holstein ve melez ırklardan oluşan toplam 411süt ineği kullanıldı. Ketoz tanısı kandaki beta-hidroksi-bütirik asit (BHBA) konsantrasyonunun ölçülmesiyle konuldu. Kan BHBA konsantrasyonları FreeStyle Optium Neo H (Abbott Diabetes Care Ltd., Witney, UK) kullanılarak analiz edildi. Kanda BHBA≥2,6 mmol/L klinik ketozis (KK), BHBA≥1,2 mmol/L olması subklinik ketozis (SKK) ve BHBA<1,2 mmol/L olması ise S olarak belirlendi. Toplam 411 süt ineğinin 76'sının (%17,88) SKK, 16'sının (%7,06) KK, 319'unun (%75,1) S olduğu belirlendi. Ketozis prevalansını azaltabilecek yönetim ve besleme stratejilerinin belirlenmesi bölge için önemlidir. Gelecek çalışmalarda daha geniş bir popülasyonda çalışılarak ikincil hastalıklar, süt verimi, ırk farklılıkları gibi farklı değişkenlerin ketozis ile birlikte incelenmesi yararlı olacaktır.

Destekleyen Kurum

TUBİTAK

Kaynakça

  • Deniz A, Aksoy K, Metin M. Transition period and subclinical ketosis in dairy cattle: association with milk production, metabolic and reproductive disorders and economic aspects. Med Weter. 2020;76 (9):495-502.
  • Redfern EA, Sinclair LA, Robinson PA. Dairy cow health and management in the transition period: The need to understand the human dimension. Res Vet Sci. 2021;137:94-101.
  • Vatnikov Y, Rudenko A, Gnezdilova L, Sotnikova E, Byakhova V, Piven E, Petrukhina O. Clinical and diagnostic characteristics of the development of hepatocardial syndrome in black and white cows in the early lactation period. Vet World. 2022;15(9):2259.
  • Uztimür M, Ünal CN. Prevalence of pregnancy toxemia in hair goats in bingöl province, Türkiye. Fırat Univ Sağlık Bilim Vet Derg. 2024;38(1):78-81.
  • Guliński P. Ketone bodies–causes and effects of their increased presence in cows’ body fluids: A review. Vet World. 2021;14(6):1492.
  • Uztimür M, Gazioğlu A, Yilmaz Ö. Changes in free amino acid profile in goats with pregnancy toxemia. Vet Res Commun. 2023;48:1-9.
  • McArt JAA, Nydam DV, Oetzel GR. Epidemiology of subclinical ketosis in early lactation dairy cattle. J Dairy Sci. 2012;95(9):5056-5066.
  • Gordon J. Risk factors for and treatment of ketosis in lactating dairy cattle. Doctoral dissertation, University of Guelph; 2013.
  • Madhesh E, Sundararajan RC, Vijayanand V, Rajesh NV, Balagangatharathilagar M, Vishnurahav RB. Therapeutic management of nervous form of ketosis in a dairy cow. Pharm Innov. 2023;12(10):1717-1719.
  • Garro CJ, Mian L, Cobos Roldán M. Subclinical ketosis in dairy cows: prevalence and risk factors in grazing production system. Anim Physiol Anim Nutr. 2014;98(5):838-844.
  • Brunner N, Groeger S, Canelas Raposo J, Bruckmaier RM, Gross JJ. Prevalence of subclinical ketosis and production diseases in dairy cows in Central and South America, Africa, Asia, Australia, New Zealand, and Eastern Europe. Transl Anım Scı. 2019;3(1):84-92.
  • Ospina PA, Nydam DV, Stokol T, Overton TR. Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases. J Dairy Sci. 2010;93(2):546-554.
  • Dohoo IR, Martin SW, Meek AH, Sandals WCD, Disease, production and culling in Holstein-Friesian cows. I. The Data. Prev Vet Med.1983;1:321-334
  • Lindström UB, Von-Bonsdorf M, Syvajarvi J. Factors affecting bovine ketosis and its association with non-return rate. J Sci Agric Soc Finl. 1984;55:497-507.
  • Haghighat-Jahromi M, Nahid S. Incidence of subclinical ketosis in dairy cows in Fars province of Iran and Reproductive performance in early lactetion period. Asian J Anim Sci. 2011;5:158-161.
  • Kennerman E. Incidence, early diagnosis of subclinical ketosis and determination of liver dysfunctions in cows in Bursa region. J Res Vet Med. 1999;18:97-107.
  • McArt JAA, Nydam DV, Overton MW. Hyperketonemia in early lactation dairy cattle: A deterministic estimate of component and total cost per case. J Dairy Sci. 2015;98(3):2043-2054.
  • Marutsova V, Binev R, Marutsov P. Comparative clinical and haematological investigations in lactating cows with subclinical and clinical ketosis. MacVet Rev. 2015;38(2):159-166.
  • Yáñez U, Herradón PG, Becerra JJ, Peña AI, Quintela LA. Relationship between postpartum metabolic status and subclinical endometritis in dairy cattle. Animals. 2022;12(3): 242.
  • Đoković R, Ilić Z, Kurćubić V, Petrović M, Cincović M, Petrović MP, Caro-Petrović V. Diagnosis of subclinical ketosis in dairy cows. Biotechnol Anim Husb. 2019;35(2):111-125.
  • Marutsova V, Binev R, Marutsov P. Comparative clinical and haematological investigations in lactating cows with subclinical and clinical ketosis. Maced Vet Rev. 2015;38(2):159-166.
  • Sun Y, Wang B, Shu S, Zhang H, Xu C, Wu L, Xia C. Critical thresholds of liver function parameters for ketosis prediction in dairy cows using receiver operating characteristic (ROC) analysis. Vet Q. 2015;35(3):159-164.
  • Cihan H, Kasap, S, Şentürk S. Comparison of beta-hydroxybutyrate levels in the first three weeks after calving in four healthy different breeds of cows. J Res Vet Med. 2023;42(1):29-31.
  • Şentürk S, Cihan H, Mecitoğlu Z, Catik S, Demir AG, Kasap S, Topal O. Prevalence of ketosis in dairy herds in Marmara, Aegean and Mediterranean regions of Turkey. Ankara Üniv Vet Fak Derg. 2016;63(3):283-288.
  • Issi M, Gül Y, Başbuğ O. Evaluation of renal and hepatic functions in cattle with subclinical and clinical ketosis. Turk J Vet Anim Sci. 2016;40(1):47-52.
  • Ayvazoğlu C, Gökçe E. Investigation of the Prevalence of Ketosis in Cows in Ardahan Region. Kocatepe Vet J. 2020;13(4):406-412.
  • Başbuğ O, Akar Y, Ercan N. The investigation of the prevalence of subclinical ketosis in Sivas region dairy cows. Eurasian J Vet Sci. 2014;30(3):123-128.
  • Duffield T. Minimizing subclinical metabolic diseases. In Tri-State Dairy Nutrition Conference, April; 2003. pp. 8-9).
  • Tatone EH, Duffield TF, LeBlanc SJ, DeVries TJ, Gordon JL. Investigating the within-herd prevalence and risk factors for ketosis in dairy cattle in Ontario as diagnosed by the test-day concentration of β-hydroxybutyrate in milk. J Dairy Sci. 2017;100(2):1308-1318.
  • Asl AN, Nazifi S, Ghasrodashti AR, Olyaee A. Prevalence of subclinical ketosis in dairy cattle in the Southwestern Iran and detection of cutoff point for NEFA and glucose concentrations for diagnosis of subclinical ketosis. Prev Vet Med. 2011;100(1):38-43.
  • Dohoo IR, Martin SW. Subclinical ketosis: prevalence and associations with production and disease. Can J Comp Med. 1984;48(1):1.

Investigation of Ketosis Prevalence in Dairy Cows in Bingöl Province of Turkey

Yıl 2024, Cilt: 5 Sayı: 3, 621 - 628, 07.12.2024
https://doi.org/10.58605/bingolsaglik.1552396

Öz

The aim of this study is to investigate the prevalence of ketosis in 7 different villages (Alibir, Ardıçtepe, Çavuşlar, Garip, Sudüğünü, Yamaç, and Yeşil) of Bingöl province. A total of 411 dairy cows, including Simmental, Holstein and crossbred breeds, were used in the study during the 3-week period after birth. Ketosis was diagnosed by measuring blood beta-hydroxy-butyric acid (BHBA) concentration. Blood BHBA concentrations were analyzed using the FreeStyle Optium Neo H (Abbott Diabetes Care Ltd., Witney, UK). Blood BHBA ≥2.6 mmol/L was determined as clinical ketosis (CK), BHBA≥1.2 mmol/L as subclinical ketosis (SCK), and BHBA<1.2 mmol/L as H. In a total of 411 dairy cows, 76 were found to be SCK (17.88%), 16 were CK (7.06%), and 319 were H (75.1%). Determining management and feeding strategies that can reduce the prevalence of ketosis is important for the region. In future studies, it would be beneficial to study a larger population and examine different variables such as secondary diseases, milk yield and racial differences together with ketosis.

Kaynakça

  • Deniz A, Aksoy K, Metin M. Transition period and subclinical ketosis in dairy cattle: association with milk production, metabolic and reproductive disorders and economic aspects. Med Weter. 2020;76 (9):495-502.
  • Redfern EA, Sinclair LA, Robinson PA. Dairy cow health and management in the transition period: The need to understand the human dimension. Res Vet Sci. 2021;137:94-101.
  • Vatnikov Y, Rudenko A, Gnezdilova L, Sotnikova E, Byakhova V, Piven E, Petrukhina O. Clinical and diagnostic characteristics of the development of hepatocardial syndrome in black and white cows in the early lactation period. Vet World. 2022;15(9):2259.
  • Uztimür M, Ünal CN. Prevalence of pregnancy toxemia in hair goats in bingöl province, Türkiye. Fırat Univ Sağlık Bilim Vet Derg. 2024;38(1):78-81.
  • Guliński P. Ketone bodies–causes and effects of their increased presence in cows’ body fluids: A review. Vet World. 2021;14(6):1492.
  • Uztimür M, Gazioğlu A, Yilmaz Ö. Changes in free amino acid profile in goats with pregnancy toxemia. Vet Res Commun. 2023;48:1-9.
  • McArt JAA, Nydam DV, Oetzel GR. Epidemiology of subclinical ketosis in early lactation dairy cattle. J Dairy Sci. 2012;95(9):5056-5066.
  • Gordon J. Risk factors for and treatment of ketosis in lactating dairy cattle. Doctoral dissertation, University of Guelph; 2013.
  • Madhesh E, Sundararajan RC, Vijayanand V, Rajesh NV, Balagangatharathilagar M, Vishnurahav RB. Therapeutic management of nervous form of ketosis in a dairy cow. Pharm Innov. 2023;12(10):1717-1719.
  • Garro CJ, Mian L, Cobos Roldán M. Subclinical ketosis in dairy cows: prevalence and risk factors in grazing production system. Anim Physiol Anim Nutr. 2014;98(5):838-844.
  • Brunner N, Groeger S, Canelas Raposo J, Bruckmaier RM, Gross JJ. Prevalence of subclinical ketosis and production diseases in dairy cows in Central and South America, Africa, Asia, Australia, New Zealand, and Eastern Europe. Transl Anım Scı. 2019;3(1):84-92.
  • Ospina PA, Nydam DV, Stokol T, Overton TR. Evaluation of nonesterified fatty acids and β-hydroxybutyrate in transition dairy cattle in the northeastern United States: Critical thresholds for prediction of clinical diseases. J Dairy Sci. 2010;93(2):546-554.
  • Dohoo IR, Martin SW, Meek AH, Sandals WCD, Disease, production and culling in Holstein-Friesian cows. I. The Data. Prev Vet Med.1983;1:321-334
  • Lindström UB, Von-Bonsdorf M, Syvajarvi J. Factors affecting bovine ketosis and its association with non-return rate. J Sci Agric Soc Finl. 1984;55:497-507.
  • Haghighat-Jahromi M, Nahid S. Incidence of subclinical ketosis in dairy cows in Fars province of Iran and Reproductive performance in early lactetion period. Asian J Anim Sci. 2011;5:158-161.
  • Kennerman E. Incidence, early diagnosis of subclinical ketosis and determination of liver dysfunctions in cows in Bursa region. J Res Vet Med. 1999;18:97-107.
  • McArt JAA, Nydam DV, Overton MW. Hyperketonemia in early lactation dairy cattle: A deterministic estimate of component and total cost per case. J Dairy Sci. 2015;98(3):2043-2054.
  • Marutsova V, Binev R, Marutsov P. Comparative clinical and haematological investigations in lactating cows with subclinical and clinical ketosis. MacVet Rev. 2015;38(2):159-166.
  • Yáñez U, Herradón PG, Becerra JJ, Peña AI, Quintela LA. Relationship between postpartum metabolic status and subclinical endometritis in dairy cattle. Animals. 2022;12(3): 242.
  • Đoković R, Ilić Z, Kurćubić V, Petrović M, Cincović M, Petrović MP, Caro-Petrović V. Diagnosis of subclinical ketosis in dairy cows. Biotechnol Anim Husb. 2019;35(2):111-125.
  • Marutsova V, Binev R, Marutsov P. Comparative clinical and haematological investigations in lactating cows with subclinical and clinical ketosis. Maced Vet Rev. 2015;38(2):159-166.
  • Sun Y, Wang B, Shu S, Zhang H, Xu C, Wu L, Xia C. Critical thresholds of liver function parameters for ketosis prediction in dairy cows using receiver operating characteristic (ROC) analysis. Vet Q. 2015;35(3):159-164.
  • Cihan H, Kasap, S, Şentürk S. Comparison of beta-hydroxybutyrate levels in the first three weeks after calving in four healthy different breeds of cows. J Res Vet Med. 2023;42(1):29-31.
  • Şentürk S, Cihan H, Mecitoğlu Z, Catik S, Demir AG, Kasap S, Topal O. Prevalence of ketosis in dairy herds in Marmara, Aegean and Mediterranean regions of Turkey. Ankara Üniv Vet Fak Derg. 2016;63(3):283-288.
  • Issi M, Gül Y, Başbuğ O. Evaluation of renal and hepatic functions in cattle with subclinical and clinical ketosis. Turk J Vet Anim Sci. 2016;40(1):47-52.
  • Ayvazoğlu C, Gökçe E. Investigation of the Prevalence of Ketosis in Cows in Ardahan Region. Kocatepe Vet J. 2020;13(4):406-412.
  • Başbuğ O, Akar Y, Ercan N. The investigation of the prevalence of subclinical ketosis in Sivas region dairy cows. Eurasian J Vet Sci. 2014;30(3):123-128.
  • Duffield T. Minimizing subclinical metabolic diseases. In Tri-State Dairy Nutrition Conference, April; 2003. pp. 8-9).
  • Tatone EH, Duffield TF, LeBlanc SJ, DeVries TJ, Gordon JL. Investigating the within-herd prevalence and risk factors for ketosis in dairy cattle in Ontario as diagnosed by the test-day concentration of β-hydroxybutyrate in milk. J Dairy Sci. 2017;100(2):1308-1318.
  • Asl AN, Nazifi S, Ghasrodashti AR, Olyaee A. Prevalence of subclinical ketosis in dairy cattle in the Southwestern Iran and detection of cutoff point for NEFA and glucose concentrations for diagnosis of subclinical ketosis. Prev Vet Med. 2011;100(1):38-43.
  • Dohoo IR, Martin SW. Subclinical ketosis: prevalence and associations with production and disease. Can J Comp Med. 1984;48(1):1.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Bilimleri (Diğer)
Bölüm Araştırma Makaleleri
Yazarlar

Cennet Nur Ünal 0000-0002-8676-6490

Ömer Aras 0009-0000-6176-3536

Murat Uztimür 0000-0001-9294-1825

Yayımlanma Tarihi 7 Aralık 2024
Gönderilme Tarihi 18 Eylül 2024
Kabul Tarihi 30 Ekim 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 5 Sayı: 3

Kaynak Göster

Vancouver Ünal CN, Aras Ö, Uztimür M. Investigation of Ketosis Prevalence in Dairy Cows in Bingöl Province of Turkey. BÜSAD. 2024;5(3):621-8.