Yeni Potansiyel Oksadiazol Türevlerinin Tetranychus urticae Koch (Prostigmata:Tetranychidae)'de Akarisidal Aktiveleri

Öz

Tetranychus urticae Koch, 1836 (Prostigmata: Tetranychidae) birçok pestisite dayanıklılık gösterdiği rapor edilen kozmopolit bir türdür. Bu sorunu önleme yöntemlerinden biri yeni etken madde gruplarının keşfidir. Yeni etken madde keşfinin maliyet ve zaman açısından önemli dezavantajları olması araştırmacıları mevcut etken maddelerde değişiklik yapmaya yöneltmiştir. Etoxazole, bazı önemli zararlı akar türlerine karşı etkili olduğu bildirilen bir etken maddedir. Bu nedenle çeşitli maddelerle türevlendirme çalışmaları yapılmaktadır. Bu çalışmada, kimyasal yapıları değiştirilebilen oxidazole grubuna bağlı hedef moleküller, biyoizosterizm yaklaşımı kullanılarak oxazoline halkasının oksadiazole ile değiştirilmesi ve halkanın C-2 ve C-4 pozisyonlarına ikame edilmiş fenil halkaları eklenmesiyle tasarlanmıştır. Yedi etken maddenin (3a, 3b, 3c, 3d, 3e, 3f, 3g) T. urticae'nin nimf dönemleri üzerindeki toksik etkileri incelendiğinde, etoxazole uygulanan kontrol grubundan sonra sırasıyla en yüksek toksik etkiler %66, %64 ve %58 oranlarında 3b, 3a ve 3g etken maddelerinde tespit edilmiştir. Yumurta dönemindeki toksik etkiler incelendiğinde ise 3a grubunun benzer toksik etki gösterdiği, diğer etkin maddelerin ise nispeten daha düşük toksik etki gösterdiği belirlenmiştir. Sonuç olarak T. urticae'nin farklı dönemlerinde etkili olan oxidazole grubu bileşiklerin türevlerinin varlığı bu zararlının kontrolünde umut verici bir yaklaşım olarak görünmektedir.

Anahtar Kelimeler

• Tetranychus urticae
• etoxazole
• oxadiazole
• akarisit

Acaricidal Activities of New Potential Oxadiazole Derivatives on Tetranychus urticae Koch (Prostigmata:Tetranychidae)

Öz

Tetranychus urticae Koch, 1836 (Prostigmata: Tetranychidae) is a cosmopolitan species known for its resistance to many pesticides. One strategy to address this challenge is the discovery of new groups of active substances. However, the high cost and time required for discovering new molecules have prompted researchers to focus on modifying existing active substances. Etoxazole is an active ingredient reported to be effective against several economically important mite species. Therefore, derivatization studies have been carried out using this compound as a lead structure. In the present study, target molecules containing modifiable oxadiazole groups were designed through a bioisosterism approach, in which the oxazoline ring was replaced with an oxadiazole ring, and substituted phenyl groups were introduced at the C-2 and C-4 positions. When the toxic effects of seven synthesized active substances (3a, 3b, 3c, 3d, 3e, 3f, and 3g) were tested against the nymphal stages of T. urticae, the highest mortality rates were observed with compounds 3b, 3a, and 3g (66%, 64%, and 58%, respectively), following the etoxazole-treated control group. At the egg stage, compound 3a exhibited toxic effects comparable to etoxazole, whereas the remaining derivatives displayed relatively lower levels of activity. In conclusion, the findings indicate that derivatives of the oxadiazole group, showing stage-specific activity against T. urticae, represent a promising approach for the development of new control strategies against this pest.

Anahtar Kelimeler

• Tetranychus urticae
• etoxazole
• oxadiazole
• acaricide

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