Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats

Elif Atabay; Yusuf Kalender

EN

Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats

Öz

Bisphenol A (BPA) is an endocrine disruptor chemical that is frequently used in industry. Taurine is a low molecular weight organic compound in living organisms. Curcumin is a yellow colored bioactive compound of turmeric with antioxidant properties. In this study, the protective effects of taurine and curcumin on the histopathological changes, antioxidant enzyme activities [superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx)] and malondialdehyde (MDA) levels that BPA may cause in the lung tissue of rats were investigated. Rats were divided into 7 groups. 1st group: control group, 2nd group: oil group, 3rd group: taurine (100 mg/kg day) treated group, 4th group: curcumin (100 mg/kg day) treated group, 5th group: BPA (130 mg/kg day) treated group group, 6th group: BPA plus taurine treated group, 7th group: BPA plus curcumin treated group. After the application by gavage for 4 weeks, a statistically significant increase was observed in the MDA levels in the lung tissues of the rats when the BPA treated group was compared with the control group, while a statistically significant decrease was observed in the antioxidant enzyme activities (SOD, CAT, GST, GPx). When the groups treated with BPA plus taurine, BPA plus curcumin were compared with the group treated with BPA, a decrease was observed in the MDA levels in the lung tissues of the rats, while a statistically significant increase was observed in SOD, CAT, GST and GPx enzyme activities. In histopathological examinations, it was determined that while BPA caused cell infiltration, hemorrhage, atrophy and emphysema in the lung tissue of rats, taurine and curcumin reduced these pathological changes.

Anahtar Kelimeler

Lung, antioxidants, bisphenol A, histopathology, oxidative stress

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Yapısal Biyoloji

Bölüm

Araştırma Makalesi

Yazarlar

Elif Atabay
0000-0003-4007-1930
Türkiye

Yusuf Kalender ^*
0000-0001-5457-0517
Türkiye

Yayımlanma Tarihi

30 Mayıs 2023

Gönderilme Tarihi

20 Nisan 2023

Kabul Tarihi

28 Nisan 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 1 Sayı: 1

IZ

https://izlik.org/JA85FA98EJ

APA

Atabay, E., & Kalender, Y. (2023). Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats. Bozok Journal of Science, 1(1), 16-22. https://izlik.org/JA85FA98EJ

AMA

1.Atabay E, Kalender Y. Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats. BJS. 2023;1(1):16-22. https://izlik.org/JA85FA98EJ

Chicago

Atabay, Elif, ve Yusuf Kalender. 2023. “Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats”. Bozok Journal of Science 1 (1): 16-22. https://izlik.org/JA85FA98EJ.

EndNote

Atabay E, Kalender Y (01 Mayıs 2023) Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats. Bozok Journal of Science 1 1 16–22.

IEEE

[1]E. Atabay ve Y. Kalender, “Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats”, BJS, c. 1, sy 1, ss. 16–22, May. 2023, [çevrimiçi]. Erişim adresi: https://izlik.org/JA85FA98EJ

ISNAD

Atabay, Elif - Kalender, Yusuf. “Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats”. Bozok Journal of Science 1/1 (01 Mayıs 2023): 16-22. https://izlik.org/JA85FA98EJ.

JAMA

1.Atabay E, Kalender Y. Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats. BJS. 2023;1:16–22.

MLA

Atabay, Elif, ve Yusuf Kalender. “Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats”. Bozok Journal of Science, c. 1, sy 1, Mayıs 2023, ss. 16-22, https://izlik.org/JA85FA98EJ.

Vancouver

1.Elif Atabay, Yusuf Kalender. Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats. BJS [Internet]. 01 Mayıs 2023;1(1):16-22. Erişim adresi: https://izlik.org/JA85FA98EJ

Öz

Protective Effect of Taurine and Curcumin on Lung Toxicity of Bisphenol A in Rats

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

IZ

Kaynak Göster