Koroner Arter Hastalığı Olmayan Hastalarda Kadın Cinsiyet ve İleri Yaş Koroner Arter Tortuozitesi İçin Bir Göstergedir

Öz

Amaç: Koroner arter tortuozitesi (KAT), invaziv koroner anjiyografide sıkça gözlenmekle birlikte etiyolojisi ve klinik önemi halen belirsizdir. Çalışmamızın amacı, koroner arter hastalığı (KAH) bulunmayan hastalarda KAT'ı etkileyen parametreleri incelemektir. Gereç ve Yöntem: KAH'ı olmayan 110 KAT izlenen hasta ile KAH ve KAT’ı olmayan 140 hasta retrospektif olarak değerlendirildi. KAT, en az bir koroner arterin ana gövdesi boyunca hem sistol hem de diyastolde izlenen, damar yönünde ≥45° değişiklik gösteren ≥3 kıvrım olarak tanımlandı. Demografik, biyokimyasal, ekokardiyografik ve anjiyografik parametreler gruplar arasında karşılaştırıldı. Bulgular: KAT'ı olan hastalar daha yaşlıydı ve çoğunlukla kadın cinsiyetteydi. KAT'lı hastaların 24'ü (%21.8) erkek, 86'sı (%78.2) kadındı. KAT'lı hastaların yaş ortalaması 61.4±10.6 yıl iken kontrol grubunun 55.9±10.9 yıl idi. KAT'lı hastaların %62.7'sinde hipertansiyon, %27.3'ünde diabetes mellitus ve %30'unda sigara kullanımı mevcuttu. Ancak gruplar arasında anlamlı bir fark yoktu (p=0.469, p=0.446, p=0.242, sırasıyla). KAT en sık izlenen koroner arter sol ön inen koroner arter (LAD) idi (%86.4). Çok değişkenli regreyon analizi yaş (p=0.019), kadın cinsiyet (p<0.001) ve KAT arasında anlamlı ilişki olduğunu gösterdi. Sonuç: Kadın cinsiyet ve ileri yaşın, koroner arter hastalığı bulunmayan hastalarda KAT'ın ana öngörücüsü olduğunu saptadık. Çalışmamızda diabetes mellitus, hipertansiyon ve sigara kullanımı gibi geleneksel risk faktörleri ile KAT gelişimi arasında anlamlı bir ilişki yoktu. KAT en sık izlenen koroner arter LAD idi. KAT’a neden olabilecek damar duvarındaki cinsiyet ve yaşa bağlı değişikliklerin altında yatan mekanizmaları anlamak için daha fazla çalışmaya ihtiyaç vardır.

Anahtar Kelimeler

• Koroner arter tortuozitesi
• Yaşlanma
• Cinsiyet

Destekleyen Kurum

Yok

Proje Numarası

Yok

Etik Beyan

Balıkesir Üniversitesi Sağlık Bilimleri Araştırmalar Etik Kurulu'ndan Karar no: 2025/2 Tarih: 07.01.2025 ile etik kurul onayı alınmıştır.

Teşekkür

Yok

Female Gender and Older Age Are a Predictor Of Coronary Artery Tortuosity In Patients With No Coronary Artery Disease

Öz

Objective: Coronary artery tortuosity (CAT) is frequently observed in invasive angiography, though its aetiology and clinical significance remain ambiguous. The aim of our study was to investigate the parameters affecting CAT in patients without normal coronary artery disease (CAD). Materials and Methods: 110 patients with CAT and no CAD and and 140 patients with no CAT and CAD were evaluated retrospectively. CAT was defined by ≥3 bends with a change in vessel direction of ≥45° present in both systole and diastole along the main trunk of at the least one coronary artery. Demographic, biochemical, echocardiogrphic and angiographic parameters were compared between groups. Results: Patients with CAT were older and more often female gender. 24 (21.8%) were males and 86 (78.2%) were females in patients with CAT. The mean age of the patients with CAT were 61.4±10.6 years and the control group was 55.9±10.9 years. Among the patients with CAT, 62.7% had hypertension, 27.3% had diabetes mellitus and 30% were smokers. But, there was not significant difference between groups (p=0.469, p=0.446, p=0.242, respectively) . Left anterior descending artery (LAD) was the most commonly affected tortuous coronary artery (86.4%). Multivariate analysis showed significant relationship between age (p=0.019), female gender (p<0.001) and CAT. Conclusion: We found that female gender and older age were a major predictor of CAT in patients with no CAD. Other traditional risk factors such as diabetes mellitus, hypertension and smoking were thought not to influence the development of CAT. LAD was the most commonly affected tortuous coronary artery. Further researches are required to understand the mechanisms underlying sex and age related changes in the arterial wall related with CAT.

Anahtar Kelimeler

• Coronary artery tortuosity
• Aging
• Gender

Destekleyen Kurum

None

Proje Numarası

Yok

Etik Beyan

This retrospective study was approved by the Balikesir University Clinical Research Ethics Commitee according to the Declaration of Helsinki (Decision No: 2025/2 Date: 07.01.2025)

Teşekkür

None

Kaynakça

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