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Üçüncü Basamak Bir Merkezde Çocuk Hematoloji Hastalarının Acil Servis Başvuruları: Klinik Özellikler ve Başvuru Örüntüleri

Yıl 2026, Cilt: 10 Sayı: 1 , 35 - 45 , 30.04.2026
https://doi.org/10.33716/bmedj.1912899
https://izlik.org/JA42DN64EF

Öz

Amaç: Çocuk hematoloji hastaları, çocuk acil servis (ÇAS) başvurularının küçük bir bölümünü oluşturmalarına rağmen, hastalığa veya tedaviye bağlı komplikasyonlar nedeniyle sıklıkla acil değerlendirme gerektirir. Bu çalışmada, üçüncü basamak bir ÇAS’a başvuran çocuk hematoloji hastalarının sosyodemografik ve klinik özellikleri, uygulanan yönetim ve sonuçlarının değerlendirilmesi amaçlandı.
Gereç ve Yöntem: Bu prospektif gözlemsel çalışmaya, 1 Nisan 2013–1 Nisan 2014 tarihleri arasında Dokuz Eylül Üniversitesi Tıp Fakültesi ÇAS’ına başvuran, daha önce hematolojik hastalık tanısı bulunan veya acil değerlendirme sırasında yeni hematolojik tanı alan 0–18 yaş arası çocuklar dahil edildi. Temel analiz birimi her bir ÇAS başvurusuydu.
Bulgular: Toplam 60.026 ÇAS başvurusunun 278’i (%0,46) hematoloji ile ilişkiliydi ve bu başvurular 96 farklı hastaya aitti. Ortalama yaş 8,16 ± 0,52 yıl olup hastaların %57,3’ü erkekti. En sık grup lösemi ile ilişkili başvurulardı (%48,6). Başvuruların %30,6’sında monitörizasyon, %51,1’inde girişim, %47,8’inde hematoloji konsültasyonu, %23,0’ünde transfüzyon ve %21,6’sında intravenöz tedavi uygulandı. Yatış oranı hematoloji ile ilişkili başvurularda %27,3, tüm ÇAS başvurularında ise %6,8 idi. Febril nötropeniye ait 23 başvurunun tamamı yatırıldı; ortalama antibiyotik başlama süresi 136,9 ± 15,9 dakikaydı.
Sonuç: Çocuk hematoloji hastaları, ÇAS başvurularının küçük ancak klinik olarak önemli bir alt grubunu oluşturmaktadır; tekrarlayan başvurular, yüksek kaynak kullanımı ve sık yatış gereksinimi ile dikkat çekmektedir.

Kaynakça

  • Burcham, M. D., Keim-Malpass, J., Lopez, M. E., Jenkins, C., Murry, D. J., Shah, A. N., et al. (2018). Emergency department chief complaints among children with cancer. Journal of Pediatric Hematology/Oncology, 40(6), 445–449.
  • Cohen, C., King, A., Lin, C. P., Friedman, G. K., Monroe, K., & Kutny, M. (2016). Protocol for reducing time to antibiotics in pediatric patients presenting to an emergency department with fever and neutropenia: Efficacy and barriers. Pediatric Emergency Care, 32(11), 739–745.
  • De Castro, G. C., Slatnick, L. R., Shannon, M., Goodman, K., Chima, R. S., Renaud, E., et al. (2024). Impact of time-to-antibiotic delivery in pediatric patients with cancer presenting with febrile neutropenia. JCO Oncology Practice, 20(2), e228–e238.
  • Jiménez-Yuste, V., Auerswald, G., Benson, G., Lambert, T., Morfini, M., Santagostino, E., et al. (2024). Management of urgent bleeding in patients with hemophilia A: Focus on the use of emicizumab. Expert Review of Hematology, 17(5), 365–376.
  • Haeusler, G. M., Dashti, S. G., Ammann, R. A., Phillips, R., Mechinaud, F., Rossoff, J., Anoop, P., Bhatt, J. M., Fisher, B. T., Thursky, K. A., Xu, X., Santolaya, M. E., & Sung, L. (2024). Impact of time to antibiotics on clinical outcome in paediatric febrile neutropenia: A target trial emulation of 1685 episodes. The Lancet Regional Health – Western Pacific, 53, Article 101226. https://doi.org/10.1016/j.lanwpc.2024.101226
  • Mueller, E. L., Sabbatini, A., Gebremariam, A., Mody, R., Sung, L., & Macy, M. L. (2015). Why pediatric patients with cancer visit the emergency department: United States, 2006–2010. Pediatric Blood & Cancer, 62(3), 490–495.
  • Neunert, C., Arnold, D. M., Grace, R. F., Buchanan, G., Imbach, P., Vesely, S. K., et al. (2024). The 2022 review of the 2019 American Society of Hematology guidelines for immune thrombocytopenia. Blood Advances, 8(8), 1889–1905.
  • Neunert, C., Terrell, D. R., Arnold, D. M., Buchanan, G., Cines, D. B., Cooper, N., et al. (2019). American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Advances, 3(23), 3829–3866.
  • O’Connell, C. P., Gattu, R., Bhatia, M., Chamberlain, L. J., Leung, K., Brousseau, D. C., et al. (2023). Pediatric cancer patient emergency department visits and hospital admissions: A population-based study. Pediatric Blood & Cancer, 70(11), e30564.
  • O’Mahony, L., O’Mahony, D. S., Simon, T. D., Neff, J., Klein, E. J., & Quan, L. (2013). Medical complexity and pediatric emergency department and inpatient utilization. Pediatrics, 131(2), e559–e565.
  • Salomon, A. L., Ammann, R. A., Haeusler, G. M., Phillips, R., Dashti, S. G., Mechinaud, F., Rossoff, J., Anoop, P., Bhatt, J. M., Fisher, B. T., Thursky, K. A., Xu, X., Santolaya, M. E., & Sung, L. (2026). Association of time to antibiotics with outcome in pediatric patients receiving chemotherapy for cancer with fever in neutropenia: An international individual patient data meta-analysis. Cancer Medicine. Advance online publication. https://doi.org/10.1002/cam4.71512
  • Simon, A., Ammann, R. A., Bate, J., Lehrnbecher, T., Moser, O., & Fleischhack, G. (2023). [Time to antibiotics (TTA)—Reassessment from the German Working Group for Fever and Neutropenia in Children and Adolescents (DGPI/GPOH)]. Klinische Pädiatrie, 235, 331–341. https://doi.org/10.1055/a-2135-4210
  • Todurkar, N., Negi, V., Kaur, N., Jain, P., Bansal, D., Marwaha, R. K., et al. (2021). Time to antibiotic administration in children with febrile neutropenia: Report from a low middle-income country. Journal of Pediatric Hematology/Oncology, 43(8), e1148–e1153.
  • Wadhwa, A., Pantell, M. S., Steinberg, J., Yang, E., Adler, E., Kobayashi, L., et al. (2022). Time to antibiotic for pediatric oncology patients with febrile neutropenia at regional emergency departments. Pediatric Emergency Care, 38(6), e1287–e1292.
  • Yoshida, H., Leger, K. J., Xu, M., Sharp, S. W., Hyman, D., Hsu, A. J., et al. (2018). Improving time to antibiotics for pediatric oncology patients with febrile neutropenia in the emergency department. Pediatrics, 141(5), e201740345

Emergency Department Presentations of Pediatric Hematology Patients at a Tertiary Care Center: Clinical Characteristics and Patterns of Use

Yıl 2026, Cilt: 10 Sayı: 1 , 35 - 45 , 30.04.2026
https://doi.org/10.33716/bmedj.1912899
https://izlik.org/JA42DN64EF

Öz

Objective: Children with hematologic diseases account for a small proportion of pediatric emergency department (PED) visits, but they often require urgent evaluation because of disease- or treatment-related complications. We aimed to evaluate the sociodemographic and clinical characteristics, management, and outcomes of pediatric hematology patients presenting to a tertiary care PED.
Materials and Methods: This prospective observational study included children aged 0–18 years presenting to the PED of Dokuz Eylul University Faculty of Medicine between April 1, 2013 and April 1, 2014, with either a previously diagnosed hematologic disease or a new hematologic diagnosis made during emergency evaluation. The primary unit of analysis was each PED visit.
Results: Among 60,026 PED visits, 278 (0.46%) were hematology-related, corresponding to 96 individual patients. Mean age was 8.16 ± 0.52 years, and 57.3% were male. Leukemia-related visits were most common (48.6%). Monitoring, procedures, consultation, transfusion, and intravenous treatment were required in 30.6%, 51.1%, 47.8%, 23.0%, and 21.6% of visits, respectively. Hospitalization occurred in 27.3% of hematology-related visits versus 6.8% of all PED visits. All 23 febrile neutropenia visits resulted in hospitalization; mean time to antibiotics was 136.9 ± 15.9 minutes.
Conclusion: Pediatric hematology patients represent a small but clinically important PED subgroup with recurrent presentations, high resource utilization, and frequent hospitalization.

Kaynakça

  • Burcham, M. D., Keim-Malpass, J., Lopez, M. E., Jenkins, C., Murry, D. J., Shah, A. N., et al. (2018). Emergency department chief complaints among children with cancer. Journal of Pediatric Hematology/Oncology, 40(6), 445–449.
  • Cohen, C., King, A., Lin, C. P., Friedman, G. K., Monroe, K., & Kutny, M. (2016). Protocol for reducing time to antibiotics in pediatric patients presenting to an emergency department with fever and neutropenia: Efficacy and barriers. Pediatric Emergency Care, 32(11), 739–745.
  • De Castro, G. C., Slatnick, L. R., Shannon, M., Goodman, K., Chima, R. S., Renaud, E., et al. (2024). Impact of time-to-antibiotic delivery in pediatric patients with cancer presenting with febrile neutropenia. JCO Oncology Practice, 20(2), e228–e238.
  • Jiménez-Yuste, V., Auerswald, G., Benson, G., Lambert, T., Morfini, M., Santagostino, E., et al. (2024). Management of urgent bleeding in patients with hemophilia A: Focus on the use of emicizumab. Expert Review of Hematology, 17(5), 365–376.
  • Haeusler, G. M., Dashti, S. G., Ammann, R. A., Phillips, R., Mechinaud, F., Rossoff, J., Anoop, P., Bhatt, J. M., Fisher, B. T., Thursky, K. A., Xu, X., Santolaya, M. E., & Sung, L. (2024). Impact of time to antibiotics on clinical outcome in paediatric febrile neutropenia: A target trial emulation of 1685 episodes. The Lancet Regional Health – Western Pacific, 53, Article 101226. https://doi.org/10.1016/j.lanwpc.2024.101226
  • Mueller, E. L., Sabbatini, A., Gebremariam, A., Mody, R., Sung, L., & Macy, M. L. (2015). Why pediatric patients with cancer visit the emergency department: United States, 2006–2010. Pediatric Blood & Cancer, 62(3), 490–495.
  • Neunert, C., Arnold, D. M., Grace, R. F., Buchanan, G., Imbach, P., Vesely, S. K., et al. (2024). The 2022 review of the 2019 American Society of Hematology guidelines for immune thrombocytopenia. Blood Advances, 8(8), 1889–1905.
  • Neunert, C., Terrell, D. R., Arnold, D. M., Buchanan, G., Cines, D. B., Cooper, N., et al. (2019). American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Advances, 3(23), 3829–3866.
  • O’Connell, C. P., Gattu, R., Bhatia, M., Chamberlain, L. J., Leung, K., Brousseau, D. C., et al. (2023). Pediatric cancer patient emergency department visits and hospital admissions: A population-based study. Pediatric Blood & Cancer, 70(11), e30564.
  • O’Mahony, L., O’Mahony, D. S., Simon, T. D., Neff, J., Klein, E. J., & Quan, L. (2013). Medical complexity and pediatric emergency department and inpatient utilization. Pediatrics, 131(2), e559–e565.
  • Salomon, A. L., Ammann, R. A., Haeusler, G. M., Phillips, R., Dashti, S. G., Mechinaud, F., Rossoff, J., Anoop, P., Bhatt, J. M., Fisher, B. T., Thursky, K. A., Xu, X., Santolaya, M. E., & Sung, L. (2026). Association of time to antibiotics with outcome in pediatric patients receiving chemotherapy for cancer with fever in neutropenia: An international individual patient data meta-analysis. Cancer Medicine. Advance online publication. https://doi.org/10.1002/cam4.71512
  • Simon, A., Ammann, R. A., Bate, J., Lehrnbecher, T., Moser, O., & Fleischhack, G. (2023). [Time to antibiotics (TTA)—Reassessment from the German Working Group for Fever and Neutropenia in Children and Adolescents (DGPI/GPOH)]. Klinische Pädiatrie, 235, 331–341. https://doi.org/10.1055/a-2135-4210
  • Todurkar, N., Negi, V., Kaur, N., Jain, P., Bansal, D., Marwaha, R. K., et al. (2021). Time to antibiotic administration in children with febrile neutropenia: Report from a low middle-income country. Journal of Pediatric Hematology/Oncology, 43(8), e1148–e1153.
  • Wadhwa, A., Pantell, M. S., Steinberg, J., Yang, E., Adler, E., Kobayashi, L., et al. (2022). Time to antibiotic for pediatric oncology patients with febrile neutropenia at regional emergency departments. Pediatric Emergency Care, 38(6), e1287–e1292.
  • Yoshida, H., Leger, K. J., Xu, M., Sharp, S. W., Hyman, D., Hsu, A. J., et al. (2018). Improving time to antibiotics for pediatric oncology patients with febrile neutropenia in the emergency department. Pediatrics, 141(5), e201740345
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Acil Tıp
Bölüm Araştırma Makalesi
Yazarlar

Atika Çağlar 0000-0003-1721-354X

Hale Ören 0000-0001-5760-8007

Murat Duman 0000-0001-6767-5748

Durgül Yılmaz 0000-0003-0132-0500

Özlem Tüfekçi Gürocak 0000-0002-0721-1025

Şebnem Yilmaz Bu kişi benim 0000-0001-7874-3734

Gönderilme Tarihi 19 Mart 2026
Kabul Tarihi 28 Nisan 2026
Yayımlanma Tarihi 30 Nisan 2026
DOI https://doi.org/10.33716/bmedj.1912899
IZ https://izlik.org/JA42DN64EF
Yayımlandığı Sayı Yıl 2026 Cilt: 10 Sayı: 1

Kaynak Göster

APA Çağlar, A., Ören, H., Duman, M., Yılmaz, D., Tüfekçi Gürocak, Ö., & Yilmaz, Ş. (2026). Emergency Department Presentations of Pediatric Hematology Patients at a Tertiary Care Center: Clinical Characteristics and Patterns of Use. Balıkesir Medical Journal, 10(1), 35-45. https://doi.org/10.33716/bmedj.1912899