EVALUATION OF RELATIONSHIP BETWEEN PAIN SCORE AND SERUM VITAMIN B12 AND FOLATE LEVELS IN FIBROMYALGIA PATIENTS

Öz

Aim: Fibromyalgia syndrome (FMS) is a common rheumatologic disorder which is characterized by chronic widespread musculoskeletal pain and several additional symptoms including morning stiffness, fatigue, sleep disorder, low pain threshold, cognitive dysfunction, anxiety and depressive episodes. Folate and vitamin B12 are two metabolically and clinically related vitamins that share some important functions related to the one-carbon metabolism and related diseases. Studies have revealed that vitamin B12 and folate are associated with pain and pain-related disorders. The aim of this study was to compare serum vitamin B12 and folate levels between FMS patient group and the control group and to present a new evidence of pathogenesis FMS disease.

Material and Methods: 46 female FMS outpatients and 46 healthy individuals were enrolled in the study. Clinical information and biochemical markers including vitamin B12, folate, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and visual analogue scale (VAS) scores were obtained from the patients’ medical files.

Results: There were no significant differences in vitamin B12, folate and ESR levels between the two groups (p >0.05). Serum CRP levels was significantly increased in FMS group (p =0.027). There was no correlation between VAS scores and biochemical markers in patients group.

Conclusions: The results of this study have indicated that vitamin B12 and folate levels are not involved in the pathogenesis of FMS. No relevant correlations between the perception of pain and one carbon metabolism biomarkers were observed in FMS patients.

Anahtar Kelimeler

• Fibromyalgia,Vitamin B12,Folate,One carbon metabolism,Pain

FİBROMİYALJİ HASTALARINDA VİTAMİN B12 VE FOLAT DÜZEYLERİ İLE AĞRI SKORLARI ARASINDAKİ İLİŞKİNİN İNCELENMESİ

Öz

Amaç: Fibromiyalji sendromu (FMS), yaygın kas iskelet sistemi ağrısı ile sabah sertliği, yorgunluk, uyku bozukluğu, düşük ağrı eşiği, bilişsel işlev bozukluğu, anksiyete ve depresif ataklar gibi ilave semptomlar ile karakterize, yaygın bir romatolojik bozukluktur. Folat ve B12 vitamini, tek karbon metabolizması ve ilişkili hastalıklarla ilgili önemli işlevleri paylaşan metabolik ve klinik olarak birbirleri ile ilişkili vitaminlerdir. Yapılan çalışmalarda, folat ve B12 vitamininin ağrı ve ağrıya bağlı rahatsızlıklarla ilişkili olduğu gösterilmiştir. Bu çalışmada, FMS hasta grubu ile kontrol grubu arasındaki serum vitamin B12 ve folat düzeylerini karşılaştırmak ve FMS hastalık patogenezine yeni kanıtlar sunmayı amaçlamaktayız.

Gereç ve Yöntem: Çalışmaya 46 kadın FMS hastası ve 46 sağlıklı birey alındı. Hastaların dosyalarından B12 vitamini, folat, eritrosit sedimantasyon hızı (ESR) ve C-reaktif protein (CRP) ve görsel analog skalası (VAS) skorları dahil olmak üzere klinik bilgi ve biyokimyasal belirteçler elde edildi.

Bulgular: İki grup arasında vitamin B12, folat ve ESR düzeylerinde anlamlı farklılık olmadığı bulundu (p> 0.05). Serum CRP düzeyleri, FMS grubunda anlamlı olarak arttığı gözlendi (p = 0.027). Hasta grubunda, VAS skorları ile biyokimyasal belirteçler arasında korelasyon olmadığı gözlendi.

Sonuç: Bu çalışma, B12 vitamini ve folat düzeylerinin FMS patogenezinde yer almadığını göstermiştir. FMS hastalarında ağrı algılaması ile tek karbon metabolizma belirteçleri arasında korelasyon gözlenmemiştir.

Anahtar Kelimeler

• Vitamin B12,Fibromiyalji,Folat,Tek karbon metabolizması,Ağrı

Kaynakça

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